Comparative pharmacodynamic modeling of the electroencephalography- slowing effect of isoflurane, sevoflurane, and desflurane

Anesthesiology

Volumn 91, Issue 2, 1999, Pages 397-405

  Rehberg, Benno ^a   Bouillon, Thomas ^b   Zinserling, Jörg ^b   Hoeft, Andreas ^b  

^a UNIVERSITY OF BONN   (Germany)

^b NONE

Author keywords

Anesthesia mechanisms; Effect compartment; Hysteresis

Indexed keywords

DESFLURANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; SEVOFLURANE;

ADULT; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ELECTROENCEPHALOGRAPHY; FEMALE; HUMAN; INHALATION ANESTHESIA; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; MODEL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPINAL CORD;

ADULT; AGED; ANESTHETICS, INHALATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; ISOFLURANE; MALE; METHYL ETHERS; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 0032839987     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199908000-00013     Document Type: Article

References (22)

1. Merkel G, Eger EI: A comparative study of halothane and halopropane anesthesia: Including the method for determining equipotency. ANESTHESIOLOGY 1963; 24:346-57
2. Rampil IJ, Mason P, Singh H: Anesthetic potency (MAC) is independent of forebrain structures in the rat. ANESTHESIOLOGY 1993; 78: 707-12
3. Antognini JF, Schwartz KS: Exaggerated anesthetic requirements in the preferentially anesthetized brain. ANESTHESIOLOGY 1993; 79:1244-9
4. Waud BE, Waud DR: On dose-response curves and anesthetics (editorial). ANESTHESIOLOGY 1970; 33:1-4
5. 95 values of common inhalation anesthetics in man. ANESTHESIOLOGY 1975; 42:384-9
6. Franks NP, Lieb WR: Molecular and cellular mechanisms of general anaesthesia. Nature 1994; 367:607-14
7. Billard V, Gambus PL, Chamoun N, Stanski DR, Shafer SL: A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect. Clin Pharmacol Ther 1997; 61:45-58
8. Katoh T, Suzuki A, Ikeda K: Electroencephalographic derivatives as a tool for predicting the depth of sedation and anesthesia induced by sevoflurane. ANESTHESIOLOGY 1998; 88:642-50
9. NONMEM Users Guide. NONMEM Project Group, University of California, San Francisco, 1994
10. Marshall BE, Longnecker DE: General anesthetics, The Pharmacological Basis of Therapeutics, 9th Edition. Edited by Hardman JG, Molinoff PB, McGraw Hill, New York 1995, pp 307-30
11. Rao CR: Linear Statistical Inference and Its Application, 2nd Edition. New York, John Wiley & Sons, 1973
12. Mapleson WW: Effect of age on MAC in humans: A meta-analysis. Br J Anaesth 1996; 76:179-85
13. Schwilden H, Stoeckel H: Quantitative EEG analysis during anaesthesia with isoflurane in nitrous oxide at 1.3 and 1.5 MAC. Br J Anaesth 1987; 59:738-45
14. Rampil IJ, Lockhart SH, Eger EI, Yasuda N, Weiskopf RB, Cahalan MK: The electroencephalographic effects of desflurane in humans. ANESTHESIOEOGY 1991; 74:434-9
15. Scott JC, Ponganis KV, Stanski DR: EEG quantiation of narcotic effect: The comparative pharmacodynamics of fentanyl and alfentanil. ANESTHESIOEOGY 1985; 62:234-41
16. Stone DJ, DiFazio CA: Anesthetic action of opiates: Correlations of lipid solubility and spectral edge. Anesth Analg 1988; 67:663-6
17. Ono K, Yasuda A, Matsukawa S, Akama M, Hashimoto Y: The effect of volatile anesthetics on EEG, auditory evoked potentials and somatosensory evoked potentials in dogs. Masui 1997; 46:471-7
18. Davidson JA, Macleod AD, Howie JC, White M, Kenny GN: Effective concentration 50 for propofol with and without 67% nitrous oxide. Acta Anaesthesiol Scand 1993; 37:458-64
19. Katoh T, Suguro Y, Kimura T, Ikeda K: Cerebral awakening concentration of sevoflurane and isoflurane predicted during slow and fast alveolar washout. Anesth Analg 1993; 77:1012-7
20. Chortkoff BS, Eger EI, Crankshaw DP, Gonsowski CT, Dutton RC, Ionescu P: Concentrations of desflurane and propofol that suppress response to command in humans. Anesth Analg 1995; 81:737-43
21. Lerman J; Pharmacokinetics of inhalational anesthetics, The Pharmacologic Basis of Anesthesiology. Edited by Bowdle TA, Horita A, Kharasch ED. New York, Churchill Livingstone, 1994, pp 523-47
22. Yasuda N, Targ AG, Eger EI: Solubility of I-653, Sevoflurane, isoflurane, and halothane in human tissues. Anesth Analg 1989; 69: 370-3