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Volumn 9, Issue 3, 1999, Pages 439-450
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Modeling the covariance structure in pharmacokinetic crossover trials
a
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Author keywords
Autocorrelation; Crossover trial; Log normal distribution; Nesting; One compartment model; Pharmacokinetics; Time varying variance; Variance components
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Indexed keywords
DRUG METABOLITE;
FLOSEQUINAN;
ADULT;
ARTICLE;
CLINICAL TRIAL;
COMPARTMENT MODEL;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
CORRELATION FUNCTION;
COVARIANCE;
CROSSOVER PROCEDURE;
DOSE RESPONSE;
DOSE TIME EFFECT RELATION;
DRUG BLOOD LEVEL;
DRUG RESEARCH;
HUMAN;
NORMAL HUMAN;
PHASE 1 CLINICAL TRIAL;
PREDICTION;
PRIORITY JOURNAL;
RANDOMIZED CONTROLLED TRIAL;
STATISTICAL MODEL;
TECHNIQUE;
VALIDATION PROCESS;
VARIANCE;
BODY FLUID COMPARTMENTS;
CLINICAL TRIALS, PHASE I;
CLINICAL TRIALS, PHASE II;
CROSS-OVER STUDIES;
DOSE-RESPONSE RELATIONSHIP, DRUG;
HUMANS;
MODELS, BIOLOGICAL;
MODELS, STATISTICAL;
MULTIVARIATE ANALYSIS;
QUINOLINES;
REGRESSION ANALYSIS;
VASODILATOR AGENTS;
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EID: 0032839478
PISSN: 10543406
EISSN: None
Source Type: Journal
DOI: 10.1081/BIP-100101186 Document Type: Article |
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Times cited : (11)
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References (16)
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