Paroxysmal nocturnal hemoglobinuria: Analysis of the effects of mutant PIG-A on gene expression

American Journal of Hematology

Volumn 61, Issue 4, 1999, Pages 221-231

  Kanai, Nobuko ^a   Vreeke, Theresa M ^a   Parker, Charles J ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Glycosyl phosphtidylinositol; Hemolytic anemia; Paroxysmal nocturnal hemoglobinuria; PIG A

Indexed keywords

ANTIQUITIN; CELL PROTEIN; GENE PRODUCT; GLYCOSYLPHOSPHATIDYLINOSITOL; PROTEIN PIG A; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CLONE; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; NUCLEOTIDE SEQUENCE; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032839335     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1096-8652(199908)61:4<221::aid-ajh1>3.0.co;2-%23     Document Type: Article

References (40)

1. Kinoshita T, Inoue N, Takeda J. Defective glycosyl phosphatidylinositol anchor synthesis and paroxysmal nocturnal hemoglobinuria. Adv Immunol 1995;60:57.
2. Nicholson-Weller A: Decay accelerating factor. Curr Top Microbiol Immunol 1992;178:7.
3. Holguin MH, Parker CJ: Membrane inhibitor of reactive lysis. Curr Top Microbiol Immunol 1992;178:61.
4. Parker CJ: Paroxysmal nocturnal hemoglobinuria and complementmediated red cell damage. Curr Opin Hematol 1994;1:151.
5. Rosse WF. Paroxysmal nocturnal hemoglobinuria, in Rosse WF (ed): Clinical Immunohematology: Basic Concepts and Clinical Applications. Boston, MA, Blackwell Scientific Publications. 1990. p. 593.
6. Kawagoe K, Kitamura D, Okabe M, Taniuchi I, Ikawa M, Watanabe T, Kinoshita T, Takeda J. Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria. Blood 1996;87:3600.
7. Iwamoto N, Kawaguchi T, Horikawa K, Nagakura S, Kagimoto T, Suda T, Takatsuki K, Nakakuma H. Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice. Blood 1996;87:4944.
8. Endo M, Beatty PG, Vreeke TM, Wittwer CT, Singh SP, Parker CJ. Syngeneic bone marrow transplantation without conditioning in a patient with paroxysmal nocturnal hemoglobinuria: in vivo evidence that the mutant stem cells have a survival advantage. Blood 1996;88:742.
9. Endo M, Ware RE, Vreeke TM, Singh SP, Howard TA, Tomita A, Holguin MH, Parker CJ. Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria. Blood 1996;87:2546.
10. Nishimura J, Inoue N, Wada H, Ueda E, Pramoonjago P, Hirota T, Machii T, Kageyama T, Kanamaru A, Takeda J, Kinoshita T, Kitani T. A patient with paroxysmal nocturnal hemoglobinuria bearing four independent PIG-A mutant clones. Blood 1997;89:3470.
11. Bessler M, Mason P, Hillmen P, Luzzatto L. Somatic mutations and cellular selection in paroxysmal nocturnal hemoglobinuria. Lancet 1994;343:951.
12. Graham DL, Gastineau DA: Paroxysmal nocturnal hemoglobinuria as a marker for clonal myelopathy. Am J Med 1992;93:671.
13. Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med 1995; 333:1253.
14. Schubert J, Vogt HG, Zielinska-Skowronek M, Freund M, Kaltwasser J, Hoelzer D, Schmidt RE. Development of glycosylphosphatidylinositol-anchoring defect characteristic of paroxysmal nocturnal hemoglobinuria in patients with aplastic anemia. Blood 1994;83:2323.
15. Griscelli-Bennaceur A, Gluckman D, Scrobohaci ML, Jonveaux P, Vu T, Bazarbachi A, Carosella ED, Sigaux F, Socié G. Aplastic anemia and paroxysmal nocturnal hemoglobinuria: search for a pathogenetic link. Blood 1995;85:1354.
16. Socié G, Henry-Amar M, Bacigalupo A, Hows J, Tichelli A, Ljungman P, McCann SR, Frichofen N, Van't Veer-Korthof EV, Gluckman E. Malignant tumors occurring after treatment of aplastic anemia. N Engl J Med 1993;329:1152.
17. Hollander N, Selvaraj P, Springer TA: Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphatidylinositolanchored proteins. J Immunol 1988;141:4283.
18. Nutman TB. Generation of antigen-nonspecific T cell lines and clones, in Coligan JE, Kruisbeek AM, Marguilies DH, Shevach EM, Strober W (eds). Current Protocols in Immunology. New York, NY, John Wiley & Sons, 1992. p. 7.19.5.
19. Medof ME, Lublin DM, Holers VM, Ayers DJ, Getty RR, Leykam JF, Atkinson JP, Tykocinski ML: Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement. Proc Natl Acad Sci USA 1987;84:2007.
20. Holguin MH, Martin CB, Weis JH, Parker CJ: Enhanced expression of the complement regulatory protein, membrane inhibitor of reactive lysis (CD59), is regulated at the level of transcription. Blood 1993;82: 968.
21. Holguin MH, Martin CB, Eggett T, Parker CJ: Analysis of the gene that encodes the complement regulatory protein, membrane inhibitor of reactive lysis (CD59): identification of an alternatively spliced exon and characterization of the transcriptional regulatory regions of the promoter. J Immunol 1996;157:659.
22. Kingston RE: Preparation of poly (A+) RNA, in Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds). Current Protocols in Molecular Biology. New York, NY: John Wiley & Sons, 1993. p. 4.5.1.
23. Iida Y, Takeda J, Miyata T, Inoue N, Nishimura J, Kitani T, Maeda K, Kinoshita T. Characterization of genomic PIG-A gene: A gene for GPI-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria. Blood 1994;83:3126.
24. Lisitsyn N, Lisitsyn N, Wigler M. Cloning the differences between two complex genomes. Science 1993;259:946.
25. Lisitsyn N, Wigler M. Representational difference analysis in detection of genetic lesions in cancer. Methods Enzymol 1995;254:291.
26. Hubank M, Schatz D: Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acid Res 1994; 22:5640-5648.
27. Takeda J, Miyata T, Kawagoe K, Iida Y, Endo Y, Fujita T, Takahashi M, Kitani T, Kinoshita T. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell 1993;73:703.
28. Miyata T, Junji T, Iida Y, Yamada N, Inoue N, Takahashi M, Maeda K, Kitani T, Kinoshita T. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science 1993;259:1318.
29. Baum C, Forster P, Hagewisch-Becker, Harbers K. An optimized electroporation protocol applicable to a wide range of cell lines. BioTech 1994;17:1058.
30. Rosse WF. The glycolipid anchor of membrane surface proteins. Sem Hematol 1993;30:219.
31. Robinson PJ. Phosphatidylinositol membrane anchors and T-cell activation. Immunol Today 1991;12:35.
32. Stulnig TM, Berger M, Sigmund T, Stockinger H, Horejsí V, Waldhäusl W. Signal transduction via glycosyl phosphatidylinositolanchored proteins in T cells is inhibited by lowering cellular cholesterol. J Biol Chem 1997;272:19242.
33. Brodsky RA, Vala MS, Barber JP, Medof ME, Jones RJ. Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci USA 1997;94:8756.
34. Lee P, Kuhl W, Gelbart T, Kamimura T, West C, Beutler E. Homology between a human protein and a protein of the green garden pea. Genomics 1994;21:371.
35. Guerro FD, Jones J, Mullet: Turgor-responsive gene transcription and RNA levels increase rapidly when pea shoots are wilted. Sequence and expression of three inducible genes. Plant Mol Biol 1990;15:11.
36. Skvorak AB, Robertson NG, Yin Y, Weremowicz S, Her H, Bieber FR, Beisel KW, Lynch ED, Beier DR, Morton CC. An ancient conserved gene expressed in the human ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1). Genomics 1997;46:191.
37. Stroeher VL, Boothe JG, Good AG. Molecular cloning and expression of a turgor-responsive gene in Brassica napus. Plant Mol Biol 1995; 27:541.
38. Hsu LC, Chang W-C, Shibuya A, Yoshida A: Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli. J Biol Chem 1992;267:3030.
39. Yoshida A, Rzhetsky A, Hsu LC, Chang C: Human aldehyde dehydrogenase gene family. Eur J Biochem 1998;251:249.
40. Kedishvili NY, Stone CL, Popov KM, Chernoff EA. Role of alcohol dehydrogenases in steroid and retinoid metabolism. Adv Exp Med Biol 1997;414:321.