Copper increases in both plasma and red blood cells at the onset of acute hepatitis in LEC rats

Research Communications in Molecular Pathology and Pharmacology

Volumn 103, Issue 2, 1999, Pages 189-194

  Suzuki, Kazuo T ^a   Shiobara, Yamato ^a   Tachibana, Akiko ^a   Ogra, Yasumitsu ^a   Matsumoto, Kozo ^b  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CERULOPLASMIN; COPPER; METALLOTHIONEIN;

ACUTE HEPATITIS; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CELL SURVIVAL; CONTROLLED STUDY; COPPER METABOLISM; ERYTHROCYTE MEMBRANE; GENE MUTATION; GOLGI COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT; RECEPTOR BINDING; WILSON DISEASE;

ANIMALS; COPPER; DISEASE MODELS, ANIMAL; ERYTHROCYTES; HEPATITIS, ANIMAL; MALE; RATS; RATS, LONG-EVANS;

EID: 0032839009     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Bull, P.C., Thomas, G.R., Rommens, J.M., Forbes, J.R. and Cox, D.W. (1993) The Wilson's disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nature Genet. 5, 327-337.
2. Danks, D.M. (1993) Disorders of copper transport. In Scriver, C.R., Beaudet, A.I., Sly, W.S. and Walle, D., eds., "The Metabolic Basis of Inherited Disease." 6th Edition. McGraw-Hill, New York, pp. 1411-1431.
3. Murata, Y., Yamawaki, E., Iizuka, T., Kodama, H., Abe, T., Seki, Y. and Kodama, M. (1995) Failure of copper incorporation into ceruloplasmin in the Golgi apparatus of LEC rat hepatocytes. Biochem. Biophys. Res. Commun. 209, 349-355.
4. Nagano, K., Nakamura, K., Urakami, K., Umeyama, K., Uchiyama, H., Koiwai, K., Hattori, S., Yamamoto, T., Matsuda, I. and Endo, F. (1998) Intracellular distribution of the Wilson's disease gene product (ATPase 7B) after in vitro and in vivo exogenous expression in hepatocytes from the LEC rat, an animal model of Wilson's disease. Hepatology 27, 799-807.
5. Petrukhin, K., Fischer, S.G., Pirastu, M., Tanzi, R.E., Chernov, I., Devoto, M., Brzustowicz, L.M., Cayanis, E., Vitale, E., Russo, J. J., Matseoane, D., Boukhgalter, B., Wasco, W., Figus, A.L., Loudianos, J., Cao, A., Sternlieb, I., Evgrafov, O., Parano, E., Pavone, L., Warburton, D., Ott, J., Penchaszadeh, G.K., Scheinberg, I.H. and Gilliam T.C. (1993) Mapping, cloning and genetic characterization of the region containing the Wilson's disease gene. Nature Genet. 5, 338-343.
6. Rui, M. and Suzuki, K.T. (1997) Copper in plasma reflects its status and subsequent toxicity in the liver of LEC rats. Res. Commun. Mol. Pathol. Pharmacol. 98, 335-346.
7. Squibb, K.S. and Fowler, B.A. (1984) Intracellular metabolism and effects of circulating cadmium-metallothionein in the kidney. Environ. Health Perspect. 54, 31-35.
8. Suzuki, K.T. and Kuroda, T. (1994) Direct transfer of copper from metallothionein to superoxide dismutase: A possible mechanism for differential supply of Cu to SOD and ceruloplasmin in LEC rats. Res. Commun. Mol. Pathol. Pharmacol. 86, 15-23.
9. Suzuki, K.T., Kanno, S., Misawa, S. and Aoki, Y. (1995) Copper metabolism leading to and following acute hepatitis in LEC rats. Toxicology 97, 81-92.
10. Suzuki, K.T., Kanno, S., Misawa, S. and Sumi, Y. (1993a) Changes of hepatic copper distribution leading to hepatitis in LEC rats. Res. Commun. Chem. Pathol. Pharmacol. 82, 217-224.
11. Suzuki, K.T., Kanno, S., Misawa, S. and Sumi, Y. (1993b) Changes in copper distribution in the plasma and kidneys of LEC rats following acute hepatitis. Res. Commun. Chem. Pathol. Pharmacol., 82, 225-232.
12. Takeichi, N. (1991) LEC rats. CRJ Letters 4, 1-8.
13. Tanzi, R.E., Petrukhin, K., Chernov, I., Pellequer, J.L., Wasco, W., Ross, B., Romano, D.M., Parano, E., Pavone, L., Brzustowicz, L. M., Devoto, M., Peppercorn, J., Bush, A.I., Sternlieb, I., Pirastu, M., Gusella, J.F., Evgrafov, O., Penchaszadeh, G.K., Honig, B., Edelman, I.S., Soares, M.B., Scheinberg, I.H. and Gilliam, T.C. (1993) The Wilson's disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nature Genet. 5, 344-350.
14. Wu, J., Forbes, J.R., Chen H.S. and Cox D.W. (1994) The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson's disease gene. Nature Genet. 7, 541.