Contribution of the glycoprotein ia 807TT, methylene tetrahydrofolate reductase 677TT and prothrombin 20210GA genotypes to prothrombotic risk among factor V 1691GA (Leiden) carriers

British Journal of Haematology

Volumn 106, Issue 1, 1999, Pages 237-239

  Hessner, Martin J ^a   Dinauer, David M ^a   Luhm, Robert A ^a   Endres, Janet L ^a   Montgomery, Robert R ^a   Friedman, Kenneth D ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

Factor V Leiden; Glycoprotein Ia; Methylene tetrahydrofolate reductase; Prothrombin; Venous thrombosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5; PROTHROMBIN; VERY LATE ACTIVATION ANTIGEN 2;

ARTICLE; GENETIC ANALYSIS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PATHOGENESIS; PENETRANCE; PRIORITY JOURNAL; RISK FACTOR; VEIN THROMBOSIS;

FACTOR V; GENOTYPE; HETEROZYGOTE; HUMANS; INTEGRINS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PROTHROMBIN; RECEPTORS, COLLAGEN; RISK FACTORS; THROMBOSIS;

EID: 0032838868     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01514.x     Document Type: Article

References (12)

1. Bertina, R.M., Koeleman, B.P.C., Koster, T., Rosendaal, F.R., Dirven, R.J., de Rhonde, H., van der Velden, P.A. & Reitsma, R.H. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature, 369, 64-67.
2. Brown, K., Luddington, R. & Baglin, T. (1998) Effect of the MTHFRC677T variant on risk of venous thromboembolism: interaction with factor V Leiden and prothrombin (F2G20210A). British Journal of Haematology, 103, 42-44.
3. Ehrenforth, S., Ludwig, G., Klinke, S., Krause, M., Scharrer, I. & Nowak-Gottl, U. (1998) The prothrombin 20210A allele is frequently coinherited in young carriers of the factor V Arg 506 to Gln mutation with venous thrombophilia. (Letter). Blood, 91, 2209-2210.
4. Frosst, P., Blom, H.J., Milos, R., Goyette, P., Sheppard, C.A., Matthews, R.G., Boers, G.J.H., den Heijer, M., Kluijtmans, L.A.J., van den Heuvel, L.P. & Rozen, R. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genetics, 10, 111-113
5. Hessner, M.J., Dinauer, D.M., Luhm, R.A., Endean, D.J., Raife, T.J., Friedman, K.D. & Kunicki, T.J. (1998) Glycoprotein Ia (α2-integrin) C807T allelic distribution among venous thrombosis patients, thrombotic thrombocytopenic purpura (TTP) patients, and six racial groups. Blood, 92, 190a (abstract).
6. Hessner, M.J., Luhm, R.A., Pearson, S.L., Endean, D.J., Friedman, K.D. & Montgomery, R.R. (1999) Prevalance of prothrombin G20210A, factor V G1691A (Leiden), and 5.10-methylene tetrahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR. Thrombosis and Haemostasis, 81, 733-738.
7. Kluijtmans, L.A., den Heijer, M., Reitsma, P.H., Heil, S.G., Blom, H.J. & Rosendaal, E.R. (1998) Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis. Thrombosis and Haemostasis, 79, 254-258.
8. 1 density is associated with two silent polymorphisms in the α2 gene coding sequence. Blood, 89, 1939-1943.
9. Moshfegh, K., Wuillemin, W.A., Redondo, M., Lammle, B., Beer, J.H., Liechti-Gallati, S. & Meyer, B.J. (1999) Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: a case control study. Lancet, 353, 351-354.
10. Poort, S.R., Rosendaal, F.R., Reitsma, P.H. & Bertina R.M. (1996) A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood, 88, 3698-3703.
11. Tosetto, A., Rodeghiero F., Martinelli, I., Stefano V., Missiaglia, E., Chiusolo, P. & Mannucci, P.M. (1998) Additional genetic risk factors for venous thromboembolism in carriers of the factor V Leiden mutation. British Journal of Haematology, 103, 871-876.
12. Zoller, B., Svensson, P.J., Dahlback, B. & Hillarp, A. (1998) The A20210 allele of the prothrombin gene is frequently associated with the factor V Arg to Gln mutation but not with protein S deficiency in thrombophilic families. (Letter). Blood, 91, 2210-2211.