Synthesis of certain quinolin-2(1H)-one α-methylene-γ-butyrolactones as potential antiplatelet agents

Heterocycles

Volumn 50, Issue 1, 1999, Pages 453-462

  Chen, Yeh Long ^a,b   Wang, Tai Chi ^a   Fang, Kuo Chang ^a   Chang, Nein Chen ^b   Tzeng, Cherng Chyi ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

7 [[2 (4 BROMOPHENYL) 2,3,4,5 TETRAHYDRO 4 METHYLENE 5 OXO 2 FURANYL]METHOXY]QUINOLIN 2(1H) ONE; 7 [[2 (4 CHLOROPHENYL) 2,3,4,5 TETRAHYDRO 4 METHYLENE 5 OXO 2 FURANYL]METHOXY]QUINOLIN 2(1H) ONE; 7 [[2,3,4,5 TETRAHYDRO 2 (4 METHOXYPHENYL) 4 METHYLENE 5 OXO 2 FURANYL]]METHOXY]QUINOLIN 2(1H) ONE; ACETIC ANHYDRIDE; ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; COUMARIN ANTICOAGULANT; LACTONE DERIVATIVE; QUINOLINE DERIVATIVE; QUINOLINOL DERIVATIVE; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; POLYMERIZATION; RABBIT; REACTION ANALYSIS;

EID: 0032838671     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-98-s(h)11     Document Type: Article

References (16)

1. K. H. Lee, I. H. Hall, E. C. Mar, C. O.Starnes, S. A. ElGebaly, T. G. Waddell, R. I. Hadgraft, C. G. Ruffner, and I. Weidner, Science, 1977, 196, 533.
2. O. Spring, K. Albert, and W. Gradmann, Phytochemistry, 1981, 20, 1883.
3. N. D. Heindel and J. A. Minatelli, J. Pharm. Sci., 1981, 70, 84.
4. H. M. R. Hoffmann and J. Rabe, Angew. Chem., Int. Ed. Engl., 1985, 24, 94.
5. E. Lee, J. W. Lim, C. H. Yoon, Y. S. Sung, Y. K. Kim, M. Yun, and S. Kim, J. Am. Chem. Soc., 1997, 119, 8391.
6. U. Sanyal, S. Mitra, P. Pal, and S. K. Chakraborti, J. Med. Chem., 1986, 29, 595.
7. J. P. Dulcere, M. N. Mihoubi, and J. Rodriguez, J. Org. Chem., 1993, 58, 5709.
8. D. F. Taber and Y. Song, J. Org. Chem., 1997, 62, 6603.
9. G. Zhu and X. Lu, J. Org. Chem., 1995, 60, 1087.
10. G. Maiti and S. C. Roy, J. Chem. Soc., Perkin Trans. 1, 1996, 403.
11. Y. L. Chen, T. C. Wang, K. H. Lee, Y. L. Chang, C. M. Teng, and C. C. Tzeng, Helv. Chim. Acta. 1996, 79, 651.
12. Y. L. Chen, T. C. Wang, S. C. Liang, C. M. Teng, and C. C. Tzeng, Chem. Pharm. Bull., 1996, 44, 1591.
13. T. Nishi, K. Yamamoto, T. Shimizu, T. Kanbe, Y. Kimura, and K. Nakagawa, Chem. Pharm. Bull., 1983, 31, 798.
14. T. Uno, Y. Ozeki, Y. Koga, G. N. Chu, M. Okada, K. Tamura, T. Igawa, F. Unemi, M. Kido, and T. Nishi, Chem. Pharm. Bull., 1995, 43, 1724.
15. C. C. Tzeng, Y. L. Chen, C. J. Wang, T. C. Wang, Y. L. Chang, and C. M. Teng, Helv. Chim. Acta, 1997, 80, 1161.
16. T. C. Wang, Y. L. Chen, K. H. Lee, and C. C. Tzeng, Synthesis, 1997, 87.