Detection of identical T-cell clonotype expansions in both the donor and recipient after allogeneic bone marrow transplantation

British Journal of Haematology

Volumn 106, Issue 1, 1999, Pages 119-127

  Trentin, Livio ^a   Imberti, Luisa ^d   Zambello, Renato ^b   Sottini, Alessandra ^e   Raimondi, Roberto ^b   Facco, Monica ^a   Cazzavillan, Sefania ^b   Bonoldi, Emanuela ^b   Signorini, Simona ^d   Bacigalupo, Andrea ^c   Semenzato, Gianpietro ^a   Rodeghiero, Francesco ^b   Primi, Daniele ^e  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b SAN BORTOLO HOSPITAL   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d III Servizio Analisi   (Italy)

^e Sorin Diagnostic   (Italy)

Author keywords

Bone marrow transplantation; Clonal T cell expansion; TCR repertoire

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CELLULAR IMMUNITY; HLA SYSTEM; HUMAN; HUMAN CELL; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AMINO ACID SEQUENCE; BLOTTING, SOUTHERN; CELL DIVISION; CLONE CELLS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, MYELOID, CHRONIC; MALE; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0032838010     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01512.x     Document Type: Article

References (35)

1. Arden, B., Clark, S.P., Kabelitz, D. & Mak, T.W. (1995) Human T-cell receptor variable gene segment families. Immunogenetics, 42, 455-500.
2. Ben Nun, A., Liblau, R.S., Cohen, L., Lehmann, D., Tournio Lasserve, E., Rosenzweig, A., Zhang, J.W., Raus, J.C. & Bach, M.A. (1991) Restriction of T cell receptor Vβ usage by myelin basic protein. Specific T-cell clones in multiple sclerosis: predominant genes vary in individuals. Proceedings of the National Academy of Sciences of the United States of America, 88, 2466-2470.
3. Brugnoni, D., Notarangelo, L.D., Sottini, A., Air, P., Pennacchio, M., Mazzolari, E., Signorini, S., Candotti, F., Villa, A., Mella, P., Vezzoni, P., Cattaneo, R., Ugazio, A.G. & Imberti, L. (1998) Development of autologous, oligoclonal, poorly functioning T lymphocytes in a patient with autosomal recessive severe combined immunodeficiency caused by defects of the Jak 3 kinase. Blood, 91, 949-955.
4. Davies, T. F., Martin, A., Conception, E. S., Graves, P., Cohen, J., & Ben-nun, A. (1991) Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. New England Journal of Medicine, 325, 238-244.
5. + cytotoxic T lymphocytes in bone marrow recipients. Bone Marrow Transplantation, 18, 339-345.
6. Fischer, A.C., Ruvolo, P.P., Horwitz, L.R. & Hess, A.D. (1995) Analysis of Vβ T-cell receptor repertoire of effector mechanims in acute and chronic graft versus host disease. Transplantation Proceedings, 27, 1366-1369.
7. + T cell expansions in normal individuals and patients with rheumatoid arthritis. Journal of Immunology 154, 3538-3547.
8. Gaschet, J., Denis, C., Milpied, N., Hallet, M.-M., Romagné, F., Necker, A., Vivien, R., David-Ameline, J., Davodeau, F., Bonneville, M. & Vié, H. (1995) Alterations of T cell repertoire after bone marrow transplantation: characterization of over-represented subsets. Bone Marrow Transplantation, 16, 427-435.
9. + subset in normal human subjects. Journal of Immunology 151, 5762-5769.
10. Kotzin, B.L., Karuturi, S., Chou, Y., Lafferty, J., Forester, J.M., Better, M., Nedwin, G.E., Offner, H. & Vandenbark, A.A. (1991) Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 88, 9161-9165.
11. Imberti, L., Sottini, A., Bettinardi, A., Puoti, M. & Primi, D. (1991) Selective depletion in HIV infection of T-cells that bear specific T cell receptor Vβ sequences. Science, 254, 860-862.
12. Loughran, T.P., Jr (1993) Clonal diseases of large granular lymphocytes. Blood, 82, 1-14.
13. Loughran, T.P.J., Coyle, T., Sherman, M., Starkebaum, G., Ehrlich, G., Ruscetti, F. & Poiesc, B. (1992) Detection of human T-cell leukemia/lymphoma virus, type II in a patient with LGL leukemia. Blood, 80, 1116-1119.
14. Masuko, K., Kato, S., Hagihara, F., Takemoto, Y., Izawa, K., Kato, T., Yamamori, S., Mizushima, Y., Nishioka, K., Tsuji, K. & Yamamoto, K. (1996) Stable clonal expansion of T cells induced by bone marrow transplantation. Blood, 87, 789-799.
15. Moebius, U., Manns, M., Hess, G., Kober, G., Meyer zum Buschenfelde, K.H. & Meuer, S.C. (1990) T cell receptor gene rearrangements of T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis (PBC): oligoclonality of PBC-derived T cell clones. European Journal of Immunology 29, 889-896.
16. + T cell repertoire in normal subjects and monozygotic twins: implications for studies of infectious and autoimmune diseases. Molecular Medicine, 1, 614-624.
17. + subset. Journal of Immunology, 154, 6182-6190.
18. Oksenberg, J.R., Stuart, S., Begovich, A.B., Bell, R.E., Erlich, H.A., Steinman, L. & Bernard, C.C. (1990) Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brain of multiple sclerosis patients. Nature, 345, 344-346.
19. Paliard, X., West, S.G., Lafferty, J.A., Clemens, J.W., Kappler, J., Marrack, P. & Kotzin, B.I., (1991) Evidence for the effecs of a superantigen in rheumatoid arthritis. Science, 253, 325-329.
20. Pandolfi, F., Zambello, R., Cafaro, A. & Semenzato, G. (1992) Biologic and clinical heterogeneity of lymphoproliferative diseases of peripheral mature T lymphocytes. Laboratory Investigation, 62, 274-302.
21. Posnett, D., Sinha, R., Kahak, S. & Russo, C. (1994) Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'benign monoclonal gammapathy'. Journal of Experimetal Medicine. 179, 609-618.
22. - large granular lymphocytes derived from the same patients suggest the persistent action of an immune-mediated selection process. Blood, 88, 2133-2143.
23. Semenzato, G., Pandolli, F., Chisesi, T., De Rossi, G., Pizzolo, G., Zambello, R., Trentin, L., Agostini, C., Dini, E., Vespignani, M., Cafaro, A., Pasqualetti, D., Giubellino, M.C., Migone, N. & Foa, R. (1987) The lymphoproliferative disease of granular lymphocytes: a heterogeneous disorder ranging from indolent to aggressive conditions. Cancer, 60, 2971-2978.
24. + T cell subsets in the allogeneic bone marrow recipient. Cancer Immunology and Immunotherapy, 41, 104-110.
25. Sottini, A., Bettinardi, A., Quiròs Roldan, E., Plebani, A., Airò, P., Primi, D. & Imberti, L. (1995) Evidence for antigenic selection of large granular lymphocytes in a patient with Wiskott-Aldrich syndrome. Blood, 86, 2240-2247.
26. Toyonaga, B., Yoshokai, Y., Vadasz, V., Chin, B. & Mak, T.W. (1985) Organization and sequences of the diversity, joining and constant region genes of the human T-cell receptor β chain. Proceedings of the National Academy of Sciences of the United States of America, 82, 8624-8628.
27. Trentin, L., Migone, N., Zambello, R., Francia di Celle, P., Aina, F., Feruglio, C., Bulian, P., Masciarelli, M., Agostini, C., Cipriani, A., Marcer, G., Foà, R., Pizzolo, G. & Semenzato, G. (1990) Mechanisms accounting for lymphocytic alveolitis in hypersensitivity pneumonitis. Journal of Immunology, 145, 2147-2154.
28. Trentin, L., Zambello, R., Facco, M., Sancetta, R., Cerutti, A., Milani, A., Tassinari, C., Crivellaro, C., Cipriani, A., Agostini, C. & Semenzato, G. (1996) Skewing of the T-cell receptor repertoire in the lung of patients with HIV-I infection. AIDS, 10, 729-737.
29. Trentin, L., Zambello, R., Facco, M., Tassinari, C., Sancetta, R., Siviero, M., Cerutti, A., Cipriani, A., Marcer, G., Majori, M., Pesci, A., Agostini, C. & Semenzato, G. (1997) Selection of T lymphocytes bearing limited TCR-Vβ regions in the lung of hypersensitivity pneumonitis and sarcoidosis. American Journal of Respiratory Critical Care Medicine, 155, 587-596.
30. + T cells in allogeneic bone marrow transplantation recipients. Journal of Immunology, 157, 5739-5747.
31. Villa, A., Santagata, S., Bozzi, F., Giliani, S., Frattini, A., Imberti, L., Benerini Gatta, L., Ochs, H.D., Schwarz, K., Notarangelo, L.D., Vezzoni, P. & Spanopoulou, E. (1998) Partial V(D)J recombination activity leads to Omenn syndrome. Cell, 93, 885-896.
32. Villers, D., Milpied, N., Gaschet, J., Davodeau, F., Hallet, M.-M., Bonneville, M. & Vié, H. (1994) Alteration of the T cell repertoire after bone marrow transplantation. Bone Marrow Transplantation, 13, 19-26.
33. Wucherpfening, K.W., Ota, K., Endo, N., Seidman, J.G., Rosenzweig, A., Weiner, H.L. & Haller, D.A. (1990) Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science, 248, 1016-1019.
34. Yamanaka, K., Kwok, W.W., Mickelson, E.M., Masewicz, S., Smith, F. & Nepon, G.T. (1993) Selective T-cell-receptor gene usage in allo-recognition and graft-versus-host disease. Transplantation, 55, 1167-1175.
35. Zambello, R., Facco, M., Trentin, L., Sancetta, R., Perin, A., Milani, A., Pizzolo, G., Rodeghiero, F., Agostini, C., Meazza, R., Ferrini, S. & Semenzato, G. (1997) Interleukin-15 triggers the proliferation and cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes. Blood, 89, 201-211.