Regulation and adaptation of glucose metabolism of the parasitic protist Leishmania donovani at the enzyme and mRNA levels

Journal of Bacteriology

Volumn 181, Issue 16, 1999, Pages 4863-4872

  Ter Kuile, Benno H ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ENZYME; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE 6 PHOSPHATE ISOMERASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCEROL KINASE; HEXOKINASE; MALATE DEHYDROGENASE (DECARBOXYLATING); MESSENGER RNA; PHOSPHOGLYCERATE KINASE; PROTEIN KINASE; SUCCINYL COENZYME A SYNTHETASE; TRIOSEPHOSPHATE ISOMERASE;

ADAPTATION; ARTICLE; CELL GROWTH; GLUCOSE METABOLISM; LEISHMANIA DONOVANI; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMASTIGOTE; PSYCHODIDAE;

LEISHMANIA DONOVANI;

EID: 0032837789     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.16.4863-4872.1999     Document Type: Article

References (45)

1. Adje, C. A., F. R. Opperdoes, and P. A. Michels. 1997. Organization, sequence and stage-specific expression of the phosphoglycerate kinase genes of Leishmania maxicana mexicana. Mol. Biochem. Parasitol. 90:155-158.
2. Altmann, M., and H. Trachsel. 1993. Regulation of translation initiation and modulation of cellular physiology. Trends Biochem. Sci. 18:429-432.
3. Bakker, B. M., P. Michels, F. R. Opperdoes, and H. V. Westerhoff. 1997. Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes. J. Biol. Chem. 272:3207-3215.
4. Bergmeyer, H. U. 1974. Methods of enzyme analysis. Academic Press, Inc., New York, N.Y.
5. Bhaumik, M., S. Das, and S. Adhya. 1991. Evidence for translational control of beta-tubulin synthesis during differentiation of Leishmania donovani. Parasitology 2:197-205.
6. Blum, J. J. 1993. Intermediary metabolism in Leishmania. Parasitol. Today 9:118-122.
7. Blum, J. J. 1994. Energy metabolism in Leishmania. J. Bioenerg. Biomembr. 26:147-155.
8. Bringaud, F., and T. Baltz. 1993. Differential regulation of two distinct families of glucose transporter genes in Trypanosoma brucei. Mol. Cell. Biol. 13:1146-1154.
9. Brun, R., and M. Schonenberger. 1979. Cultivation and in vitro cloning of procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Acta Trop. 36:289-292.
10. Brusell, E. 1970. Introduction to insect physiology. Academic Press, Inc., New York, N.Y.
11. Callens, M., D. A. Kuntz, and F. R. Opperdoes. 1991. Kinetic properties of fructose bisphosphate aldolase from Trypanosoma brucei compared to aldolase from rabbit muscle and Staphylococcus aureus. Mol. Biochem. Parasitol. 47:1-9.
12. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
13. Darling, T. N., D. G. Davis, R. E. London, and J. J. Blum. 1989. Carbon dioxide abolishes the reverse Pasteur effect in Leishmania. Mol. Biochem. Parasitol. 33:191-202.
14. Etges, R., and A. J. Mukkada. 1988. Purification and characterization of a metabolite-regulated pyruvate kinase from Leishmania major promastigotes. Mol. Biochem. Parasitol. 27:281-289.
15. Fell, D. 1997. Understanding the control of metabolism. Portland Press, London, England.
16. Fell, D. A., and S. Thomas. 1995. Physiological control of metabolic flux: the requirement for multisite modulation. Biochem. J. 311:35-39.
17. Hart, D. T., and F. R. Opperdoes. 1984. The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species. Mol. Biochem. Parasitol. 13:159-172.
18. Hotz, H. R., P. Lorenz, R. Fischer, S. Krieger, and C. Clayton. 1995. Role of 3′-untranslated regions in the regulation of hexose transporter mRNAs in Trypanosoma brucei. Mol. Biochem. Parasitol. 75:1-14.
19. Keegan, F. P., and J. J. Blum. 1992. Utilization of a carbohydrate reserve comprised primarily of mannose by Leishmania donovani. Mol. Biochem. Parasitol. 53:193-200.
20. Kleijn, M., G. C. Scheper, H. O. Voorma, and A. A. Thomas. 1998. Regulation of translation initiation factors by signal transduction. Eur. J. Biochem. 253:531-544.
21. Langford, C. K., S. A. Ewbank, S. S. Hanson, B. Ullman, and S. M. Landfear. 1992. Molecular characterization of two genes encoding members of the glucose transporter superfamily in the parasitic protozoan Leishmania donovani. Mol. Biochem. Parasitol. 55:51-64.
22. McCarthy, J. E. G. 1998. Posttranscriptional control of gene expression in yeast. Microbiol. Mol. Biol. Rev. 62:1492-1553.
23. Mertens, E., E. Van Schaftingen, and M. Müller. 1992. Pyruvate kinase from Trichomonas vaginalis, an allosteric enzyme stimulated by ribose 5-phosphate and glycerate 3-phosphate. Mol. Biochem. Parasitol. 54:13-20.
24. Müller, S., E. Boles, M. May, and F. K. Zimmermann. 1995. Different internal metabolites trigger the induction of glycolytic gene expression in Saccharomyces cerevisiae. J. Bacteriol. 177:4517-4519.
25. Opperdoes, F. R. 1987. Compartmentation of carbohydrate metabolism in trypanosomes. Annu. Rev. Microbiol. 41:127-151.
26. Opperdoes, F. R., and P. Borst. 1977. Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Lett. 80:360-364.
27. Sierkstra, L. N., N. P. Nouwen, J. M. Verbakel, and C. T. Verrips. 1993. Regulation of glycolytic enzymes and the Crabtree effect in galactose-limited continuous cultures of Saccharomyces cerevisiae. Yeast 9:787-795.
28. Soto, M., J. M. Requena, L. Quijada, and C. Alonso. 1996. Organization, transcription and regulation of the Leishmania infantum histone H3 genes. Biochem. J. 318:813-819.
29. Stouthamer, A. H. 1979. The search for correlation between theoretical and experimental growth yields. Int. Rev. Biochem. 21:1-47.
30. Swinkels, B. W., A. Loiseau, F. R. Opperdoes, and P. Borst. 1992. A phosphoglycerate kinase-related gene conserved between Trypanosoma brucei and Crithidia fasciculata. Mol. Biochem. Parasitol. 50:69-78.
31. Ter Kuile, B. H. 1994. Carbohydrate metabolism and physiology of the parasitic protist Trichomonas vaginalis studied in chemostats. Microbiology 140:2495-2502.
32. Ter Kuile, B. H. 1996. Metabolic adaptation of Trichomonas vaginalis to growth rate and glucose availability. Microbiology 142:3337-3345.
33. Ter Kuile, B. H. 1997. Adaptation of metabolic enzyme activities of Trypanosoma brucei promastigotes to growth rate and carbon regimen. J. Bacteriol. 179:4699-4705.
34. Ter Kuile, B. H., and Y. Bonilla. 1999. Influence of growth conditions on RNA levels in relation to activity of core metabolic enzymes in the parasitic protists Trypanosoma brucei and Trichomonas vaginalis. Microbiology 145: 755-765.
35. Ter Kuile, B. H., and F. R. Opperdoes. 1991. Chemostat cultures of Leishmania donovani promastigotes and Trypanosoma brucei procyclic trypomastigotes. Mol. Biochem. Parasitol. 45:171-173.
36. Ter Kuile, B. H., and F. R. Opperdoes. 1992. Comparative physiology of two protozoan parasites, Leishmania donovani and Trypanosoma brucei, grown in chemostats. J. Bacteriol. 174:2929-2934.
37. Ter Kuile, B. H., and F. R. Opperdoes. 1993. Uptake and turnover of glucose in Leishmania donovani. Mol. Biochem. Parasitol. 60:313-321.
38. Tielens, A., and J. J. Van Hellemond. 1998. Differences in energy metabolism between Trypanosomatidae. Parasitol. Today 14:265-271.
39. Vanhamme, L., and E. Pays. 1995. Control of gene expression in trypanosomes. Microbiol. Rev. 59:223-240.
40. Van Hellemond, J. J., F. R. Opperdoes, and A. G. M. Tielens. 1998. Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA transferase. Proc. Natl. Acad. Sci. USA 95:3036-3041.
41. van Schaftingen, E., F. R. Opperdoes, and H. G. Hers. 1985. Stimulation of Trypanosoma brucei pyruvate kinase by fructose-2,6-bisphosphate. Eur. J. Biochem. 153:403-406.
42. Van Schaftingen, E., F. R. Opperdoes, and H. G. Hers. 1987. Effects of various metabolic conditions and of the trivalent arsenical melarsen oxide on the intracellular levels of fructose 2,6-bisphosphate and of glycolytic intermediates in Trypanosoma brucei. Eur. J. Biochem. 166:653-661.
43. Veldkamp, H. 1976. Continuous culture in microbial physiology and ecology. Meadowfield Press, Durham, United Kingdom.
44. Westerhoff, H. V., P. R. Jensen, J. L. Snoep, and B. N. Kholodenko. 1998. Thermodynamics of complexity - the live cell. Thermochim. Acta 309:111-120.
45. Westerhoff, H. V., and D. Kahn. 1993. Control involving metabolism and gene expression: the square-matrix. Acta Biotheor. 41:75-83.