Iron overload in urban Africans in the 1990s

Gut

Volumn 45, Issue 2, 1999, Pages 278-283

  Gangaidzo, I T ^a   Moyo, V M ^a   Saungweme, T ^a   Khumalo, H ^a   Charakupa, R M ^b   Gomo, Z A R ^b   Loyevsky, M ^e   Stearman, R ^c   La Vaute, T ^c   Enquist, E G ^d   Rouault, T A ^c   Gordeuk, V R ^e  

^a UNIVERSITY OF ZIMBABWE   (Zimbabwe)

^b UNIV OF ZIMBABWE MEDICAL SCHOOL   (Zimbabwe)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Africa; Cirrhosis; Haemochromarosis; Haemosiderosis; Iron; Liver

Indexed keywords

DNA; IRON;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HEART; HEMOCHROMATOSIS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IRON OVERLOAD; IRON STORAGE; LIVER; LIVER CELL; LIVER CIRRHOSIS; LIVER INJURY; LUNG; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; NEGRO; PRIORITY JOURNAL; SKIN; SPLEEN; URBAN AREA; ZIMBABWE;

EID: 0032837356     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.45.2.278     Document Type: Article

References (35)

1. Edwards CQ, Griffen LM, Goldgar D, et al. Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N Engl J Med 1988;318:1355-62.
2. Gordeuk VR. Hereditary and nutritional iron overload. Balliere's Clin Haematol 1992;5:169-86.
3. Bothwell TH, Seftel H, Jacobs P. Iron overload in Bantu subjects. Studies on the availability of iron in Bantu beer. Am J Clin Nutr 1964;14:47-51.
4. Bothwell TH, Bradlow BA. Siderosis in the Bantu. A combined histopathological and chemical study. Arch Pathol 1960;70:279-92.
5. Isaacson C, Seftel HC, Keeley KJ, et al. Siderosis in the Bantu: the relationship between iron overload and cirrhosis. J Lab Clin Med 1961;58:845-53.
6. Gordeuk VR, MacPhail AP, MacLaren CE, et al. Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited. Blood 1996;87:3470-6.
7. Gangaidzo IT, Gordeuk VR. Hepatocellular carcinoma and African iron overload. Gut 1995;37:727-30.
8. Moyo VM, Makunike R, Gangaidzo IT, et al. African iron overload and hepatocellular carcinoma. Eur J Haematol 1998;60:28-34.
9. Moyo VM, Gangaidzu IT, Gomo ZAR, et al. Traditional beer consumption and the iron status of spouse pairs from a rural community in Zimbabwe. Blood 1997;89:2159-66
10. MacPhail AP, Simon MO, Torrance JD, et al. Changing patterns of dietary iron overload in black South Africans. Am J Clin Nutr 1979;32:1272-8.
11. Rabson AR, Hallett AF, Koornhof HJ. Generalised Yersinia enterocolytica infection. J Infect Dis 1975;131:447-51.
12. Gordeuk V, Mukiibi J, Hasstedt SJ, et al. Iron overload in Africa: interaction between a gene and dietary iron content. N Engl J Med 1992;326:95-110.
13. Torrance JD, Bothwell TH. Tissue iron stores. In: Cook JD, ed. Iron. New York: Churchill Livingstone, 1980:90-115.
14. Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurement in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986;6:24-9.
15. Scheuer PJ. Disturbances of copper and iron metabolism. In: Scheuer PJ, ed. Liver biopsy interpretation. London: Balliere Tindall, 1980:189-99.
16. Sheehan DC, Hrapchak BB. Theory and practice of histotechnology. Columbus: Batelle Press, 1987.
17. Scheuer PJ, Williams R, Muir AR. Hepatic pathology in relatives of patients with hemochromatosis. J Pathol Bacteriol 1962;84:53-64.
18. Edwards CQ, Caroll M, Bray P, et al. Hereditary hemochromatosis. Diagnosis in siblings and children. N Engl J Med 1977;297:7-13.
19. Gordeuk VR, McLaren GD, Samowitz W. Etiologies, consequences, and treatment of iron overload. Crit Rev Clin Lab Sci 1994;31:89-133.
20. Friedman BM, Baynes RD, Bothwell TH, et al. Dietary iron overload in southern African rural blacks. S Afr Med J 1990;78:301-5.
21. Feder JN, Gnirke AA, Thomas W, et al. A novel NHC class 1-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408.
22. Bothwell TH, Isaacson C. Siderosis in the Bantu. A comparison of incidence in males and females. BMJ 1962;1:522-4.
23. Summers KM, Halliday JW, Powell LW. Identification of homozygous hemochromatosis subjects by measurement of hepatic iron index. Hepatology 1990;12:20-5.
24. Sallie RW, Reed WD, Shilkin KB. Confirmation of the efficacy of hepatic tissue iron index in differentiating genetic hemochromatosis from alcoholic liver disease complicated by alcoholic haemosiderosis. Gut 1991;32:207-10.
25. Bothwell TH, Abrahams C, Bradlow BA. Idiopathic and Bantu haemochromatosis: comparative histological study. Arch Pathol 1965;79:163-8.
26. Prieto J, Barry M, Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver disease. Gastroenterology 1975;68:525-33.
27. Ford C, Wells FE, Rogers JN. Assessment of iron status in association with excess alcohol consumption. Ann Clin Biochem 1995;32:527-31.
28. Wapnick AA, Bothwell TH, Seftel H. The relationship between serum iron levels and ascorbic acid stores in siderotic Bantu. Br J Haematol 1970;19:271-6.
29. Bothwell TH, Charlton RW, Cook JD, et al. Iron metabolism in man. Oxford: Blackwell Scientific Publications, 1979.
30. Brittenham GM, Farrell DE, Harris JW, et al. Magnetic-susceptibility measurement of human iron stores. N Engl J Med 1982;307:1671-5.
31. Guyader D, Gandon Y, Deugnier Y, et al. Evaluation of computed tomography in the assessment of liver iron overload: a study 46 cases of idiopathic hemochromatosis. Gastroenterology 1989;97:737-43.
32. Anderson PB, Birgerd G, Nyman R, et al. Magnetic resonance imaging in idiopathic hemochromatosis. Eur J Haematol 1991;47:174-8.
33. Finch CA, Huebers H. Perspectives in iron metabolism. N Engl J Med 1982;306:1520-8.
34. Gordeuk VR, Boyd RD, Brittenham GM. Dietary iron overload persists in rural sub-Saharan Africa. Lancet 1986;i:1310-13.
35. Ludwig J, Hashimoto E, Porayko MK, et al. Hemosiderosis in cirrhosis: a study of 447 native livers. Gastroenterology 1997;112:882-8.