Subcutaneous glucose predicts plasma glucose independent of insulin: Implications for continuous monitoring

American Journal of Physiology - Endocrinology and Metabolism

Volumn 277, Issue 3 40-3, 1999, Pages

  Rebrin, Kerstin ^a   Steil, Garry M ^b   Van Antwerp, William P ^a   Mastrototaro, John J ^a  

^a MiniMed Inc   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Continuous glucose sensor; Interstitial fluid; Subcutaneous tissue

Indexed keywords

GLUCOSE; INSULIN; SOMATOSTATIN;

AMPEROMETRY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; GLUCOSE HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; INSULIN DEFICIENCY; INTERSTITIAL FLUID; NONHUMAN; PRIORITY JOURNAL; SENSOR;

EID: 0032836714     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.277.3.e561     Document Type: Article

References (41)

1. Aalders, A. L., F. J. Schmidt, A. J. M. Schoonen, I. R. Broek, G. F. M. Maessen, and H. Doorenbos. Development of a wearable glucose sensor; studies in healthy volunteers and in diabetic patients. Int. J. Artif. Organs 14: 102-108, 1991.
2. Abel, P., A. Müller, and U. Fischer. Experience with an implantable glucose sensor as a prerequisite of an artificial beta cell. Biomed. Biochim. Acta 43: 577-584, 1984.
3. Ader, M., and R. N. Bergman. Importance of transcapillary insulin transport to dynamics of insulin action after intravenous glucose. Am. J. Physiol. 266 (Endocrinol Metab. 29): E17-E25, 1994.
4. Bantle, J., and W. Thomas. Glucose monitoring using dermal interstitial fluid (Abstract). Diabetes 46: 619, 1997.
5. Bindra, D. S., Y. Zhang, G. S. Wilson, R. Sternberg, D. R. Thévenot, D. Moatti, and G. Reach. Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring. Anal. Chem. 63: 1692-1696, 1991.
6. Bolinder, J., U. Ungerstedt, and P. Arner. Microdialysis measurement of the absolute glucose concentration in subcutaneous adipose tissue allowing glucose monitoring in diabetic patients. Diabetologia 35: 1177-1180, 1992.
7. Bunow, B., and G. Knott. MLAB: A Mathematical Modeling Laboratory. Bethesda, MD: Civilized Software, 1995.
8. Claremont, D. J., I. E. Sambrook, C. Penton, and J. C. Pickup. Subcutaneous implantation of a ferrocene-mediated glucose sensor in pigs. Diabetologia 29: 817-821, 1986.
9. Clark, L. C., and C. Lyons. Electrode systems for continuous monitoring cardiovascular surgery. Ann. NY Acad. Sci. 102: 29-45, 1962.
10. Fischer, U. Continuous in vivo monitoring in diabetes: the subcutaneous glucose concentration. Acta Anaesthesiol. Scand. 9, Suppl. 104: 21-29, 1995.
11. Fischer, U., R. Ertle, P. Abel, K. Rebrin, E. Brunstein, H. Hahn von Dorsche, and E. J. Freyse. Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs. Diabetologia 30: 940-945, 1987.
12. Hagström-Toft, E., E. Moberg, P. Arner, and J. Bolinder. Protracted glucose fall in subcutaneous adipose tissue and skeletal muscle during insulin-induced hypoglycemia (Abstract). Horm. Metab. Res. 29: 19, 1997.
13. Janle-Swain, E., J. F. Van Vleet, and S. R. Ash. Use of capillary filtrate collector for monitoring glucose in diabetes. Trans. Am. Soc. Artif. Intern. Organs 10: 336-340, 1987.
14. Janssson, P. A., J. Fowelin, U. Smith, and P. Lönnroth. Characterization by microdialysis of intercellular glucose level in subcutaneous tissue in humans. Am. J. Physiol. 255 (Endocrinol. Metab. 18): E218-E220, 1988.
15. Johnson, K. W., J. J. Mastrototaro, D. C. Howey, R. L. Brunelle, P. L. Burden-Brady, N. A. Bryan, C. C. Andrew, H. M. Rowe, D. J. Allen, B. W. Noffke, W. C. McMaham, R. J. Morff, D. Lipson, and R. S. Nevin. In vivo evaluation of an electroenzymatic glucose sensor implanted in subcutaneous tissue. Biosens. Bioelectron. 7: 709-714, 1992.
16. Lönnroth, P., R-A. Janssson, and U. Smith. A microdialysis method allowing characterization of intercellular water space in humans. Am. J. Physiol. 253 (Endocrinol. Metab. 16): E228-E231, 1987.
17. Maggs, D. G., R. Jacob, F. Rife, R. Lange, P. Leone, M. J. During, W. V. Tamborlane, and R. S. Sherwin. Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. J. Clin. Invest. 96: 370-377, 1995.
18. Mastrototaro, J. J., K. W. Johnson, R. J. Morff, D. Lipson, C. C. Andrew, and D. J. Allen. An electroenzymatic glucose sensor fabricated on a flexible substrate. Sensors and Actuators 5: 139-144, 1991.
19. Moberg, E., E. Hagström-Toft, P. Arner, and J. Bolinder. Protracted glucose fall in subcutaneous adipose tissue and skeletal muscle compared with blood during insulin-induced hypoglycaemia. Diabetologia 40: 1320-1326, 1997.
20. Mueller, M., R. Schmidt, M. Nieszpaur-Los, A. Fassolt, P. Lönnroth, P. Fasching, and H. G. Eichler. Key metabolite kinetics in human skeletal muscle during ischaemia and reperfusion: measurement by microdialysis. Eur. J. Clin. Invest. 25: 601-607, 1995.
21. Pfeiffer, E. F., C. Meyerhoff, F. Bischof, F. S. Keck, and W. Kerner. On line continuous monitoring of subcutaneous tissue glucose is feasible by combining portable glucosensor with microdialysis. Horm. Metab. Res. 25: 121-124, 1993.
22. Pickup, J. C., G. S. Shaw, and D. J. Claremont. In vivo molecular sensing in diabetes mellitus: an implantable glucose sensor with direct electron transfer. Diabetologia 32: 213-217, 1989.
23. Poulin, R. A., G. M. Steil, D. M. Moore, M. Ader, and R. N. Bergman. Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes 43: 180-190, 1994.
24. Proakis, J. G., and D. G. Manolakis. Digital Signal Processing: Principles, Algorithms, and Applications. Englewood Cliffs, NJ: Prentice-Hall, 1996.
25. Quinn, C. P., M. V. Pishko, D. W. Schmidtke, M. Ishikava, J. G. Wagner, P. Raskin, J. A. Hubbel, and A. Heller. Kinetics of glucose delivery to subcutaneous tissue in rats measured with 0.3-mm amperometric microsensors. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E155-E161, 1995.
26. Rebrin, K., U. Fischer, H. Hahn von Dorsche, T. von Woedtke, P. Abel, and E. Brunstein. Subcutaneous glucose monitoring by means of electrochemical sensors: fiction or reality? J. Biomed. Eng. 14: 33-40, 1992.
27. Rebrin, K., U. Fischer, T. von Woedtke, P. Abel, and E. Brunstein. Automated feedback control of subcutaneous glucose concentration in diabetic dogs. Diabetologia 32: 573-576, 1989.
28. Schaupp, L., M. Ellmerer, G. A. Brunner, A. Wutte, G. Sendlhofer, Z. Trajanoski, F. Skrabal, T. R. Pieber, and P. Wach. Direct access to interstitial fluid in adipose tissue in humans using open-flow microperfusion. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E401-E408, 1999.
29. Schmidt, F., W. J. Sluiter, and A. J. M. Schoonen. Glucose concentration in subcutaneous extracellular space. Diabetes Care 16: 695-700, 1993.
30. Schmidtke, D. W., A. C. Freeland, A. Heller, and R. T. Bonnecaze. Measurement and modeling of the transient difference between blood, and subcutaneous glucose concentrations in the rat after injection of insulin. Proc. Natl. Acad. Sci. USA 95: 294-299, 1998.
31. Service, F. J., P. C. O'Brien, S. D. Wise, S. Ness, and S. M. LeBlanc. Dermal interstitial glucose as an indicator of ambient glycemia. Diabetes Care 20: 1426-1429, 1997.
32. Shichiri, M., R. Kawamori, Y. Goriya, Y. Yamasaki, M. Nomura, and H. Abe. Glycaemic control in pancreatectomized dogs with a wearable artificial endocrine pancreas. Diabetologia 24: 179-184, 1983.
33. Steil, G. M., M. Ader, D. M. Moore, K. Rebrin, and R. N. Bergman. Transendothelial insulin transport is not saturable in vivo: no direct evidence for a receptor mediated process. J. Clin. Invest. 97: 1497-1503, 1996.
34. Steil, G. M., M. A. Meador, and R. N. Bergman. Thoracic duct lymph. Relative contribution from splanchnic and muscle tissue. Diabetes 42: 720-731, 1993.
35. Steil, G. M., K. Rebrin, S. D. Mittelman, and R. N. Bergman. Role of portal insulin delivery to the disappearance of intravenous glucose and assessment of insulin sensitivity. Diabetes 47: 714-720, 1998.
36. Sternberg, F., C. Meyerhoff, F. J. Mennel, F. Bischof, and E. F. Pfeiffer. Subcutaneous glucose concentration in humans. Diabetes Care 18: 1266-1269, 1995.
37. Sternberg, F., C. Meyerhoff, F. J. Mennel, H. Mayer, F. Bischof, and E. F. Pfeiffer. Does fall in tissue glucose precede fall in blood glucose? Diabetologia 39: 609-612, 1996.
38. Tamada, J. A., N. J. V. Bohannon, and R. O. Potts. Measurement of glucose in diabetic subjects using noninvasive transdermal extraction. Nat. Med. 1: 1198-1201, 1995.
39. Thomé-Duret, V., G. Reach, M. N. Gangnerau, F. Lemonnier, J. C. Klein, Y. Zhang, and G. S. Wilson. Use of a subcutaneous glucose sensor to detect decreases in glucose concentration prior to observation in blood. Anal. Chem. 68: 3822-3826, 1996.
40. Wientjes, K. J., P. Vonk, Y. Vonk-Van Klei, A. J. M. Schoonen, and N. W. Kossen. Microdialysis of glucose in subcutaneous adipose tissue up to 3 weeks in healthy volunteers. Diabetes Care 21: 1481-1488, 1998.
41. Wolfson, S. K., J. F. Tokarsky, S. J. Yao, and M. A. Krupper. Glucose concentration at possible sensor tissue implant sites. Diabetes Care 5: 162-165, 1982.