Glucose and amino acid kinetic response to graded infusion of rhIGF-I in the late gestation ovine fetus

American Journal of Physiology - Endocrinology and Metabolism

Volumn 277, Issue 3 40-3, 1999, Pages

  Liechty, Edward A ^a,b   Boyle, David W ^a   Moorehead, Helen ^a   Lee, Wei Hua ^a   Yang, Xian Lin ^a   Denne, Scott C ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Riley R 208 ^*  (United States)

Author keywords

Leucine; Phenylalanine; Stable isotopes; Tyrosine

Indexed keywords

RECOMBINANT SOMATOMEDIN C;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; GLUCOSE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SHEEP;

EID: 0032834072     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.277.3.e537     Document Type: Article

References (30)

1. Birnbaum, R. S., R. R. Bowsher, and K. M. Wiren. Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts. J. Endocrinol. 144: 251-259, 1995.
2. Boulware, S. D., W. V. Tamborlane, N. J. Rennert, N. Gesundheit, and R. S. Sherwin. Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults. J. Clin. Invest. 93: 1131-1139, 1994.
3. Bowsher, R. R., W. H. Lee, J. M. Apathy, P. J. O'Brien, A. L. Ferguson, and D. P. Henry. Measurement of insulin-like growth factor-II in physiological fluids and tissues. I. An improved extraction procedure and radioimmunoassay for human and rat fluids. Endocrinology 128: 805-814, 1991.
4. 13C]tyrosine in the postabsorptive state. Metabolism 31: 999-1005, 1982.
5. Denne, S. C., E. A. Liechty, Y. M. Liu, G. Brechtel, and A. D. Baron. Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults. Am. J. Physiol. 261 (Endocrinol. Metab. 24): E809-E814, 1991.
6. Fant, M., C. Salafia, R. C. Baxter, J. Schwander, C. Vogel, J. Pezzullo, and F. Moya. Circulating levels of IGFs and IGF binding proteins in human cord serum: relationships to intrauterine growth. Regul. Pept. 48: 29-39, 1993.
7. Flakoll, P. J., M. Kulaylat, M. Frexes-Steed, H. Hani, L. L. Brown, J. O. Hill, and N. N. Abumrad. Amino acids augment insulin's suppression of whole body proteolysis. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E839-E847, 1989.
8. Fryburg, D. A. Insulin-like growth factor I exerts growth hormone-and insulin-like actions on human muscle protein metabolism. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E331-E336, 1994.
9. Gatford, K. L., K. J. Quinn, P. E. Walton, B. J. Hosking, A. R. Egan, and P. C. Owens. Ontogenic and nutritional changes in circulating insulin-like growth factor (IGF)-I, IGF-II and IGF-binding proteins in growing ewe and ram lambs. J. Endocrinol. 155: 47-54, 1997.
10. Harding, J. E., L. Liu, P. C. Evans, and P. D. Gluckman. Insulin-like growth factor 1 alters feto-placental protein and carbohydrate metabolism in fetal sheep. Endocrinology 134: 1509-1514, 1994.
11. Hay, W. W., Jr. Effects of insulin and glucose concentrations on glucose utilization in fetal sheep. Pediatr. Res. 23: 381-387, 1988.
12. Hay, W. W., Jr., and H. K. Meznarich. The effect of hyperinsulinaemia on glucose utilization and oxidation and on oxygen consumption in the fetal lamb. Q. J. Exp. Physiol. 71: 689-698, 1986.
13. Hay, W. W., Jr., H. K. Meznarich, J. W. Sparks, F. C. Battaglia, and G. Meschia. Effect of insulin on glucose uptake in near term fetal lambs. Proc. Soc. Exp. Biol. Med. 178, 557-564, 1985.
14. Hay, W. W., Jr., J. W. Sparks, B. Quissell, F. C. Battaglia, and G. Meschia. Simultaneous measurements of umbilical uptake fetal utilization rate and fetal turnover rate of glucose. Am. J. Physiol. 240 (Endocrinol. Metab. 3): E662-E668, 1981.
15. Iwamoto, H. S., and C. J. McConnell. Effect of fetal nephrectomy on insulin-like growth factors and their binding proteins in sheep. Biol. Neonate 71: 92-101, 1997.
16. Kalhan, S. C., K. Y. Tserng, C. Gilifan, and L. J. Dierker. Metabolism of urea and glucose in normal and diabetic pregnancy. Metabolism 31: 824-833, 1982.
17. Leger, J., J. F. Oury, M. Noel, S. Baron, K. Benali, P. Blot, and P. Czernichow. Growth factors and intrauterine growth retardation. 1. Serum growth hormone, insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein 3 levels in normally grown and growth-retarded human fetuses during the second half of gestation. Pediatr. Res. 40: 94-100, 1996.
18. Liechty, E. A., D. W. Boyle, W.-H. Lee, R. R. Bowsher, and S. C. Denne. Effects of circulating IGF-I on glucose and amino acid kinetics in the ovine fetus. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E177-E185, 1996.
19. Liechty, E. A., D. W. Boyle, H. Moorehead, Y. M. Liu, and S. C. Denne. Effect of hyperinsulinemia on ovine fetal leucine kinetics during prolonged maternal fasting. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E696-E702, 1992.
20. Liechty, E. A., S. C. Denne, J. A. Lemons, and C. L. Kien. Effects of glucose infusion on leucine transamination and oxidation in the ovine fetus. Pediatr. Res. 30: 423-429, 1991.
21. Meier, P., R. Peterson, D. Bonds, G. Meschia, and F. C. Battaglia. Rates of protein synthesis and turnover in fetal life. Am. J. Physiol. 240 (Endocrinol. Metab. 3): E320-E324, 1981.
22. Meschia, G., J. R. Cotter, E. L. Makowski, and D. H. Barron. Simultaneous measurement of uterine and umbilical blood flows and oxygen uptakes. Q. J. Exp. Physiol. 52: 1-18, 1966.
23. Milley, J. R. Effects of insulin on ovine fetal leucine kinetics and protein metabolism. J. Clin. Invest. 93: 1616-1624, 1994.
24. Millward, J. Insulin and the Regulation of Amino Acid Catabolistn and Protein Turnover. Amino Acid Metabolism and Therapy in Health and Nutritional Disease. Cleveland, OH: CRC, 1995, p. 127-138.
25. Poindexter, B. B., C. A. Karn, J. A. Ahlrichs, J. Wang, C. A. Leitch, E. A. Liechty, and S. C. Denne. Amino acids suppress proteolysis independent of insulin throughout the neonatal period. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E592-E599, 1997.
26. Rosenblatt, J., and R. R. Wolfe. Calculation of substrate flux using stable isotopes. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E526-E531, 1988.
27. Russell-Jones, D. L., and M. Umpleby. Protein anabolic action of insulin, growth hormone and insulin-like growth factor I. Eur. J. Endocrinol. 135: 631-642, 1996.
28. Schwenk, W. F., P. J. Berg, B. Beaufrère, J. M. Miles, and M. W. Haymond. Use of t-butyldimethylsilylation in the gas chromatographic/mass spectrometric analysis of physiologic compounds found in plasma using electron-impact ionization. Anal. Biochem. 141: 101-109, 1984.
29. Turkalj, I., U. Keller, R. Ninnis, S. Vosmeer, and W. Stauffacher. Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man. J. Clin. Endocrinol. Metab. 75: 1186-1191, 1992.
30. Umpleby, A. M., F. Shojaee-Moradie, M. J. Thomason, J. M. Kelly, A. Skottner, P. H. Sonksen, and R. H. Jones. Effects of insulin-like growth factor-I (IGF-I), insulin and combined IGF-I-insulin infusions on protein metabolism in dogs. Eur. J. Clin. Invest. 24: 337-344, 1994.