Clonidine action in spontaneously hypertensive rats (SHR) depends on the GABAergic system function

Amino Acids

Volumn 17, Issue 2, 1999, Pages 131-138

  Gozlinska B ^a   Czyzewska Szafran, Halina ^a  

^a NATIONAL MEDICINES INSTITUTE   (Poland)

Author keywords

Amino acids; Clonidine; GABA turnover; GABA(A) receptor antagonists; SHR; WKY rats

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICUCULLINE; CLONIDINE; PICROTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GABAERGIC SYSTEM; HYPERTENSION; HYPOTENSION; MEDULLA OBLONGATA; NONHUMAN; PONS; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BICUCULLINE; BLOOD PRESSURE; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HYPOTHALAMUS; MEDULLA OBLONGATA; PICROTOXIN; PONS; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 0032833540     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01361876     Document Type: Article

References (26)

1. Balcom GJ, Lenox RH, Meyerhoff JL (1975) Regional gamma-aminobutyric acid levels in rats brain determined after microvawe fixation. J Neurochem 24: 609-613
2. Carmona, E, Gomes C, Trolin G (1980) On the importance of GABAergic neurons for the AOAA-induced accumulation of GABA in the rat brain. Naunyn-Schmiedebergs Arch Pharmacol 313: 221-224
3. Czyzewska-Szafran H, Wutkiewicz M (1986) The actvity of glutamate decarboxylase and the turnover of γ-aminobutyric acid in spontaneously hypertensive rats. Pol J Pharmacol Pharm 38: 135-141
4. Czyzewska-Szafran H, Wutkiewicz M, Remiszewska M, Jastrzȩbski Z, Czarnecki A, Danysz A (1989) Down-regulation of the GABAergic system in selected brain areas of spontaneously hypertensive rats (SHR). Pol J Pharmacol Pharm 41: 619-627
5. Czyzewska-Szafran H, Jastrzȩbski Z, Remiszewska M, Wutkiewicz M (1991) Effect of clonidine on blood pressure and GABAergic mechanism in spontaneously hypertensive rats, Eur J Pharmacol 198: 115-120
6. Dalas S, Laverly WH, Nc Neil JR (1986) Clonidine fails to reduce pressor responsiveness of conscious spontaneously hypertensive rats to vasopressin. Can J Physiol 64: 284-289
7. Hambley J, Johnston G, A, R, Shaw J (1984) Alteration in a hypothalamic GABA system in the spontaneously hypertensive rat. Neurochem Int 6: 813-821
8. Jastrzȩbski Z, Coźlińska B, Czyzewska-Szafran H (1993) Pharmacodynamic interaction of clonidine and muscimol in hypertension. Res Commun Chem Pathol Pharmacol 81: 113-116
9. Karege F, Gaillard JM (1990) Metabolism time-course of monoamines in rat brain after low dose of clonidine. Biog Amine 7: 37-48
10. 2 receptors in the caudate nucleus of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. Brain Res 602: 119-125
11. Lowe JP, Robins E, Eyerman GS (1958) The fluorimetric measurement of glutamic decarboxylase and its distribution in brain. J Neurochem 3: 8-12
12. Lowry OH, Rosebrough NY, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
13. Marmo E, Filippelli W, Manazzo R, Russo S, Cazzola M, Vacca C, Ross F (1987) Participation of GABAergic mechanisms in the hypotensive and bradycardic effects of clonidine: experimental study in conscious normotensive and hypertensive rats. Neuropharmacology 26: 1525-1528
14. 2 presynaptic adrenoceptors differentially located in rat cerebral cortex subregion. J Pharmacol Exp Ther 245: 682-686
15. Sasaki S, Nakata, T, Kawasaki S, Hayashi J, Oguro M, Takeda KK (1990) Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats. J Cardiovasc Pharmacol 15: 706-713
16. Sasaki S, Kuwabara T, Yoshitomu T, Yoneda Y, Takenako K, Takesako T, Tanaka M (1992) Decreased hypothalamic and medullary GABA turnover in spontaneously hypertensive rats. Cardiovasc Res 26: 261-264
17. Schultz BG, Schröder G, Stock G (1988) Contribution of serotonergic systems to maintenance of blood pressure in anaesthetized normotensive Wistar-Kyoto and conscious spontaneously hypertensive rats. Drugs 36 [Suppl] 1: 102-104
18. Singewald N, Pfitscher A, Philippu A (1992) Effects of gamma-vinyl GABA (vigabAtrin) on blood pressure and body weight of hypertensive and normotensive rats. Naunyn-Schmiedebergs Arch Pharmacol 345: 181-186
19. A and excitatory amino-acid receptors controlling heart rate in rats. Am J Physiol 261: R427-R433
20. Tibirica E, Feldman J, Bousquet P (1988) Differences in the ability of yohimbine to antagonize the hypotensive effect of clonidine in normotensive and spontaneously hypertensive anesthetized rats. J Pharmacol Exp Ther 244: 1062-1066
21. Uchida T, O'Brien D (1964) The effect of hydrazines on rat brain 5-hydroxytryptamine, norepinephrine and gamma-aminobutyric acid. Biochem Pharmacol 13: 725-730
22. Weekley LB, Phan T, Narasimhachari N, Johanssen J, Boadle-Biber MC (1985) Effect of clonidine on the activity of tryptophan hydroxylase from rat brain stem following in vivo or in vitro treatment. Biochem Pharmacol 34: 1549-1557
23. Wible JH Jr, Luft FC, Di Micco IA (1988) Hypothalamic GABA supresses sympathetic outflow to the cardiovascular system. Am J Physiol 254: R680-R687
24. Wible JH Jr, Di Micco IA, Luft FC (1989) Hypothalamic GABA and sympathetic regulation in spontaneously hypertensive rats. Hypertension 14: 623-628
25. Yang ChCH, Chan JYH, Pan JT, Chan SHH (1994) Differential neuronal responses to angiotensin III from the subfornical organ of normotensive and spontaneously hypertensive rats. Brain Res 638: 169-174
26. Yoneda Y, Kanmori K, Ida S, Kuriyama K (1983) Stress-induced alterations in metabolism of γ-aminobutyric acid in rat brain. J Neurochem 40: 350-355