Effect of adenosine derivatives on in vitro thrombus formation induced by shear stress

Haematologica

Volumn 84, Issue 8, 1999, Pages 721-725

  Menegatti, Marzia ^b   Cristalli, Gloria ^b   Gallo, Luciana ^b   Mannucci, Pier Mannuccio ^b   Pareti, Francesco I ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NONE

Author keywords

Adenosine derivatives; CAMP; Cyclic adenosine monophosphate; Filteraggregometer; P selectin; Von Willebrand's factor; VWF

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE DERIVATIVE; CYCLIC AMP; N ETHYL 1' DEOXY 1' [6 AMINO 2 (3 HYDROXY 1 PENTYN 1 YL) 9H PURIN 9 YL]BETA DEXTRO RIBOFURONAMIDE; N ETHYL 1' DEOXY 1' [6 AMINO 2 (5 CYANO 1 PENTYN 1 YL) 9H PURIN 9 YL]BETA DEXTRO RIBOFURONAMIDE; PADGEM PROTEIN; SP 50; SP 64; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; SHEAR STRESS; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOGENESIS;

ADENOSINE; CYCLIC AMP; HUMANS; P-SELECTIN; PLATELET AGGREGATION; STRESS, MECHANICAL;

EID: 0032833343     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Fuster V, Steele PM, Chesebro JH. Role of platelets and thrombosis in coronary atherosclerotic disease and sudden death. J Am Coll Cardiol 1985; 5:175B-84B.
2. Savage B, Saldivar E, Ruggeri ZM. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell 1996; 84:289-97.
3. Ruggeri ZM. Perspectives series: cell adhesion in vascular biology. J Clin Invest 1997; 99:559-64.
4. Aleviadrou BR, McIntire LV. Rheology. In: Thrombosis and Hemorrhage ed. Blackwell Scientific Publ.; 1994. p. 369-81.
5. Tangelder GJ, Slaaf DW, Arts T, Reneman RS. Wall shear rate in arterioles in vivo: least estimates from platelet velocity profiles. Am J Physiol 1988; 254: H1059-64.
6. Moake JL, Turner NA, Stathopulos NA, Nolasco LH, Hellums JD. Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation. J Clin Invest 1986; 78:1456-61.
7. Chow TW, Hellums JD, Moake JL, Kroll MH. Shear stress-induced von Willebrand factor binding to glycoprotein lb initiates calcium influx associated with aggregation. Blood 1992; 1:133-48.
8. Ruggeri ZM. Mechanism of shear-induced platelet adhesion and aggregation. Blood 1989; 73:418-27.
9. Brown CH, Leverett LB, Lewis CW, Alfrey CP, Hellums JD. Morphological, biochemical and functional changes in human platelets subjected to shear-stress. J Lab Clin Med 1975; 86:462-76.
10. Brass LF, Shattil SJ. Changes in surface-bound and exchangeable calcium during platelet activation. J Biol Chem 1982; 257:14000-5.
11. Evangelista V, Piccardoni P, White JG, de Gaetano G, Cerletti C. Cathepsin G-dependent platelet stimulation by activated polymorphonuclear leukocytes and its inhibition by antiproteinase: role of P-selectin-mediated cell-cell adhesion. Blood 1993; 81:2947-57.
12. Maugeri N, Evangelista V, Celardo A, et al. Polymorphonuclear leukocyte-platelet interaction: role of P-selectin in thromboxane B2 and leukotriene C4 cooperative synthesis. Thromb Haemost 1994; 72:450-6.
13. Cerletti C, Evangelista V, de Gaetano G. Platelet-polymorphonuclear leukocyte functional interactions: role of adhesive molecules. Haemostasis 1996; 26:20-7
14. Kostantopoulos K, Neelamegham S, Bums AR, et al. Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and b2-integrin. Circulation 1998; 873-82.
15. Simpson PJ, Mickelson J, Fantone JC, Gallagher KP, Lucchesi BR. Iloprost inhibits neutrophil function in vitro and in vivo and limits experimental infarct size in canine heart. Circ Res 1987; 60:666-73.
16. Neumann FJ, Marx N, Gawaz M, et al. Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation 1997; 95:2387-94.
17. Gawaz M, Neumann FJ, Ott I, Schiessler A, Scomig A. Platelet function in acute myocardial infarction treated with direct angioplasty. Circulation 1996; 93:229-37.
18. Alevriadou BR, Moake JL, Ruggeri ZM, et al. Real time analysis of shear dependent thrombus formation and its blockade by inhibitors on von Willebrand factor binding to platelets. Blood 1993; 81:1263-76.
19. Moake JL, Turner NA, Stathopoulos NA, Nolasco LH, Helluns JD. Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin. Blood 1988; 71:1366-74.
20. Cattaneo M, Lombardi R, Bettega D, Lecchi A, Mannucci PM. Shear-induced platelet aggregation is potentiated by desmopressin and inhibited by ticlopidine. Arterioscler Thromb 1993; 13:393-7.
21. Mills DCB, Smith JB. The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3':5'-cyclic monophosphate in platelets. Biochem J 1971; 121:185-96.
22. O'Brien JR, Salmon GP. Shear-stress activation of platelet glycoprotein IIb/IIIa von Willebrand factor causes aggregation filter blockage and the long bleeding time in von Willebrand's disease. Blood 1987; 70:1354-61.
23. Haslam RJ, Rosson GM. Effects of adenosine on levels of adenosine-cyclic 3',5'-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation. Mol Pharmacol 1975; 11: 528-44.
24. Cristalli G, Volpini R, Vittori S, et al. 2-alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. J Med Chem 1994; 37:1720-6.
25. Cristalli G, Eleuteri A, Vittori S, Volpini R, Lohse MJ, Klotz K. 2 - alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. J Med Chem 1992; 35:2363-8.
26. Michelson AD. Flow cytometry: a clinical test of platelet function. Blood 1996; 87: 4925-36.
27. Dionisotti S, Zocchi C, Varani K, Borea PA, Ongini E. Effects of adenosine derivatives on human and rabbit platelet aggregation. Naunyn-Schmiedeberg's Arc Pharmacol 1992; 346:673-6.
28. Cristalli G, Vittori S, Thompson RD, et al. Inhibition of platelet aggregation by adenosine receptor agonists. Naunyn-Schmiedeberg's Arc Pharmacol 1994; 349:644-50.
29. Cristalli G, Camaioni E, Di Francesco E, Vittori S, Volpini R. Chemical and pharmacological profile of selective adenosine receptor agonists. In: Giardinà D, Piergentili A, Pigini M eds. Proceedings of the tenth Camerino-Noordwijkerhout Symposium. Camerino; 1995. p 165-80.
30. McEver RP, Moore KL, Cummings RD. Leukocyte trafficking mediated by selectin-carbohydrate interaction. J Biol Chem 1995; 270:11025-8.
31. Pareti FI, Cattaneo M, Carpinelli L, et al. Evaluation of the abnormal platelet function in von Willebrand disease by the blood filtration test. Thromb Haem 1996; 75:460-8.
32. Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194:927-9.