Low cell motility induced by hsp27 overexpression decreases osteolytic bone metastases of human breast cancer cells in vivo

Journal of Bone and Mineral Research

Volumn 14, Issue 9, 1999, Pages 1570-1575

  Lemieux, Pierre ^a   Harvey, J ^b   Guise, Theresa ^b   Dallas, Mark ^b   Oesterreich, Steffi ^b   Yin, Juan Juan ^b   Selander, Katri ^b   Fuqua, Suzanne ^b  

^a Angiotech Pharmaceuticals Inc   (Canada)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 27;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE METASTASIS; BREAST CANCER; CELL MOTILITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OSTEOLYSIS; PROTEIN EXPRESSION;

ANIMALS; BONE NEOPLASMS; BREAST NEOPLASMS; CELL MOVEMENT; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; MICE; NEOPLASM PROTEINS; OSTEOLYSIS; PARATHYROID HORMONE-RELATED PROTEIN; PROTEINS; TUMOR CELLS, CULTURED;

EID: 0032833144     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.9.1570     Document Type: Article

References (24)

1. Aarons A 1994 The management of cancer metastatic to bone. JAMA 15:1206-1209.
2. Zucker S, Lysik R, Zarrabi M, Moll U 1993 Mr 92,000 type IV collagenase is increased in plasma of patients with colon cancer and breast cancer. Cancer Res 53:140-146.
3. De Clerck Y, Perez N, Shimida H, Boone T, Langley K, Taylor S 1992 Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res 52:701-708.
4. Mbalaviele G, Dunstan C, Sasaki A, Williams P, Mundy G, Yoneda T 1996 E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res 56:4063-4070.
5. Taube T, Elomaa I, Blomqvist C, Benton M, Kanis J 1994 Histomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancer. Bone 15:161-166.
6. Guise T, Mundy G 1995 Breast cancer and bone. Curr Opi Endocrinol Diabetes 2:548-555.
7. Guise T, Yin J, Taylor S, Kumagal Y, Dallas M, Boyce B, Yoneda T, Mundy G 1996 Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest 98:1-6.
8. Pfeilschifter J, Mundy G 1987 Modulation of transforming growth factor activity in bone cultures by osteotropic hormones. Proc Natl Acad Sci USA 84:2024-2028.
9. Orr F, Varani J, Gondek M, Ward P, Mundy G 1979 Chemotactic responses of tumor cells to products of resorbing bone. Science 203:176-179.
10. Arguello F, Furlanetto RW, Baggs RB, Graves BT, Harwell SE, Cohen HJ, Frantz CN 1992 Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes S1/S1d and W/Wv). Cancer Res 52:2304-2309.
11. Lemieux P, Oesterreich S, Lawrence J, Steeg P, Hilsenbeck S, Fuqua S 1998 The small heat shock protein hsp27 increases invasiveness but decreases motility of breast cancer cells. Invasion Metastasis 17:113-123.
12. Oesterreich S, Weng C-N, Qui M, Hilsenbeck S, Osborne C, Fuqua S 1993 The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res 53:4443-4448.
13. Sasaki A, Boyce B, Story B, Wright K, Chapman M, Boyce R, Mundy G, Yoneda Y 1995 Bisphosphonate residronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res 55:3551-3557.
14. Guise T, Yoneda T, Yates A, Mundy G 1993 The combined effect of tumor-produced parathyroid hormone-related peptide and transforming growth factor-α enhance hypercalcemia in vivo and bone resorption in vitro. J Clin Endocrinol Metab 77:40-45.
15. Pandian M, Morgan C, Carlton E, Segre G 1992 Modified immunoradiometric assay of parathyroid hormone-related protein: Clinical application in the differential diagnosis of hypercalcemia. Clin Chem 38:282-288.
16. Takeichi M 1993 Cadherins in cancer: Implications for invasion and metastasis. Curr Opin Cell Biol 5:806-811.
17. Orr W, Kostenuik P, Sanchez-Sweatman O, Singh G 1993 Mechanisms involved in the metastasis of cancer to bone. Breast Cancer Res Treat 25:151-163.
18. Nakai M, Mundy G, Williams P, Boyce B, Yoneda T 1992 A synthetic antagonist to laminin inhibits the formation of osteolytic metastases by human melanoma cells in nude mice. Cancer Res 52:5395-5399.
19. Wewer U, Tarboletti G, Sobel M, Albrechtsen R, Liotta L 1987 Laminin receptor: Role in tumor cell migration. Cancer Res 47:5691-5698.
20. Iwamoto Y, Robey F, Graf J, Sasaki M, Kleinman K, Yamada Y, Martin G 1987 YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation. Science 238:1132-1134.
21. Kantor J, McCormick B, Steeg P, Zetter B 1993 Inhibition of cell motility after nm23 transfection of human and murine tumor cells. Cancer Res 53:717-720.
22. Achbarou A, Kaiser S, Tremblay G, Ste-Marie L-G, Brodt P, Goltzman D, Rabbani S 1994 Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo. Cancer Res 54:2372-2377.
23. Oesterreich S, Weng C-N, Qiu M, Hilsenbeck SG, Osborne CK, Fuqua SAW 1993 Heat shock protein 27 is correlated with growth and drug resistance in human breast cancer cells. Cancer Res 53:4443-4448.
24. Garrido C, Otavi P, Fromentin A, Hammann A, Arrigo A-P, Chauffert B, Mehlen P 1997 Hsp27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res 57:2661-2667.