HgCl2-induced human lymphocyte activation in vitro: A superantigenic mechanism?

International Archives of Allergy and Immunology

Volumn 120, Issue 1, 1999, Pages 63-70

  Loftenius, Annika ^a,b   Ekstrand, Jan ^a   Möller, Erna ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b School of Dentistry   (Sweden)

Author keywords

Human; Lymphocyte; Mercury; Superantigen; T cell receptor V chain

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MERCURY CHLORIDE; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 2; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANTIGEN EXPRESSION; ARTICLE; BLAST TRANSFORMATION; BLOOD DONOR; CELL CULTURE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOBLAST; MATHEMATICAL ANALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENTAL AMALGAM; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MERCURIC CHLORIDE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SUPERANTIGENS; T-LYMPHOCYTE SUBSETS;

EID: 0032832903     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024221     Document Type: Article

References (55)

1. World Health Organization: Inorganic Mercury: Environmental Health Criteria 118. Geneva, World Health Organization, 1991.
2. US Public Health Service and Department of Health and Human Services: Dental amalgam: A Scientific Review and Recommended Public Health Service Strategy for Research, Education, and Regulation. Washington, US DHHS, 1993.
3. Swedish Medical Research Council: Potential Biological Consequences of Mercury Released form Dental Amalgam. A State of the Art Document. Stockholm, Swedish Medical Research Council, 1992.
4. Bariety J, Druet P, Laliberte F, Sapin C: Glomerulonephritis with γ and β1C-globulin deposits induced in rats by mercuric chloride. Am J Pathol 1971;65:293-302.
5. Sapin C, Druet E, Druet P: Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride. Clin Exp Immunol 1977;28:173-179.
6. Goter Robinson CJ, Abraham AA, Balazs T: Induction of anti-nuclear antibodies by mercuric chloride in mice. Clin Exp Immunol 1984;58:300-306.
7. Hultman P, Eneström S: Mercury induced antinuclear antibodies in mice: Characterization and correlation with renal immune complex deposits. Clin Exp Immunol 1988;71: 269-274.
8. Ishii N, Ishii H, Nakajima H, Aoki I, Shimoda N: Contact sensitivity to mercuric chloride is associated with 1-A region in mice. J Dermatol Sci 1991;2:268-273.
9. Aten J, Veninga A, De Heer E, Rozing J, Nieuwenhuis P, Hoedemaeker PJ, Weening JJ: Susceptibility to the induction of either autoimmunity or immunosuppression by mercuric chloride is related to the major histocompatibility complex class II haplotype. Eur J Immunol 1991;21:611-616.
10. Hultman P, Bell LJ, Eneström S, Pollard KM: Murine susceptibility to mercury. II. Autoanti-body profiles and renal immune deposits in hybrid, backcross, and H-2d congenic mice. Clin Immunol Immunopathol 1993;68:9-20.
11. Magnusson B, Blohm SG, Fregert S, Hjorth N, Hovding G, Pirila V, Skog E: Routine patch testing. IV, Supplementary series of test substances for Scandinavian countries. Acta Derm Venereol (Stockh) 1968;48:110-114.
12. Bolewska J, Hansen HJ, Holmstrup P, Pindborg JJ, Stangerup M: Oral mucosal lesions related to silver amalgam restoration. Oral Surg Oral Med Oral Pathol 1990;70:55-58.
13. Al-Tawil NG, Mercusson JA, Möller E: Lymphocyte transformation test in patients with nickel sensitivity: An aid to diagnosis. Acta Derm Venereol (Stockh) 1981;61:511-515.
14. Al-Tawil NG, Marcusson JA, Möller E: Lymphocyte stimulation by trivalent and hexavalent chromium compounds in patients with chromium sensitivity: An aid to diagnosis. Acta Derm Venereol (Stockh) 1983;63:296-303.
15. Al-Tawil NG, Marcusson JA, Möller E: In vitro testing for cobalt sensitivity: An aid to diagnosis. Acta Derm Venereol (Stockh) 1984;64: 203-208.
16. Kreiss K, Newman LS, Mroz MM, Campbell PA: Screening blood test identifies subclinical beryllium disease. J Occup Med 1989;31:603-608.
17. Sinigaglia F, Scheidegger D, Garotta G, Scheper R, Pletscher M, Lanzavecchia A: Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis. J Immunol 1985;135:3929-3932.
18. Emtestam L, Carlsson B, Marcusson JA, Wallin J, Möller E: Specificity of HLA restricting elements for human nickel reactive T-cell clones. Tissue Antigens 1989;33:531-541.
19. Saltini C, Winestock BA, Kirby M, Pinkston P, Crystal RG: Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T cells. N Engl J Med 1989;320:1103-1109.
20. Romagnoli P, Spinas GA, Sinigaglia F: Gold-specific T-cells in rheumatoid arthritis patients treated with gold. J Clin Invest 1992;89:254-258.
21. Schöpf E, Schulz KH, Isensee I: Lymphocyte transformation in mercury hypersensitivity. Non-specific transformation due to mercury compounds. Arch Klin Exp Dermatol 1969; 234:420-433.
22. Caron GA, Poutala S, Provost TT: Lymphocyte transformation induced by inorganic and organic mercury. Int Arch Allergy Appl Immunol 1970;37:76-87.
23. Nordlind K, Henze A: Stimulating effect of mercuric chloride and nickel sulfate on DNA synthesis of thymocytes and peripheral blood lymphocytes in children. Int Arch Allergy Appl Immunol 1984;73:162-165.
24. Laine J, Happonen R-P, Vainio O, Kalimo K: In vitro lymphocyte proliferation test in the mucosal hypersensitivity reactions to dental amalgam. J Oral Pathol Med 1997;26:362-366.
25. 2) on human mononuclear cells. Clin Exp Immunol 1997; 110:418-422.
26. Möller G (ed): Lymphocyte activation by mitogens: Models for immunocyte triggering. Transplant Rev 1972;11.
27. Johansson A, Möller E: Evidence that the immunosuppressive effects of FK506 and cyclosporine are identical. Transplantation 1990; 50:1001-1007.
28. 2 on murine lymphocytes. I. Preferable activation of CD4+ T cells in a responder strain. J Immunol 1995;154:3138-3146.
29. 2 on murine lymphocytes. II. Selective activation of T cells expressing certain Vβ TCR. Int Immunol 1996;8:1729-1736.
30. Marrack P, Kappler J: The staphylococcal enterotoxins and their relatives. Science 1990; 248:705-711.
31. Arden B, Clark SP, Kabelitz D, Mak TW: Human T-cell receptor variable gene segment families. Immunogenetics 1995;42:455-500.
32. Drake CG, Kotzin BL: Superantigens: Biology, immunology, and potential role in disease. J Clin Immunol 1992;12:149-162.
33. Fleischer B, Schrezenmeier H: T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells. J Exp Med 1988; 167:1697-1707.
34. Nordlind K, Liden S: In vitro lymphocyte reactivity to heavy metal salts in the diagnosis of oral mucosal hypersensitivity to amalgam restorations. Br J Dermatol 1993;128:38-41.
35. Kappler J, Kotzin B, Herron L, Gelfand EW, Bigler RD, Boylston A, Carrel S, Posnett DN, Choi Y, Marrack P: Vβ-specific stimulation of human T cells by staphylococcal toxins. Science 1989;244:811-813.
36. Utschig LM, Wright JG, O'Halloran TV: Biochemical and spectroscopic probes of mercury(II) coordination environments in proteins. Methods Enzymol 1993;266:71-97.
37. Sandborgh Englund G, Dahlqvist R, Lindelöf B, Söderman E, Jonzon B, Vesterberg O, Larsson KS: DMSA administration to patients with alleged mercury poisoning from dental amalgams: A placebo-controlled study. J Dent Res 1994;73:620-628.
38. Aposhian HV, Aposhian MM: Meso-2,3-dimercaptosuccinic acid: Chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. Annu Rev Pharmacol Toxicol 1990;30:279-306.
39. Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi Y, Stauffacher C, Strominger JL, Wiley DC: Three-dimensional structure of a human class II histocompability molecule complexed with superantigen. Nature 1994; 368:711-718.
40. Hu H, Möller G, Abedi-Valugerdi M: Major histocompatibility complex class II antigens are required for both cytokine production and proliferation induced by mercuric chloride in vitro. J Autoimmun 1997;10:441-446.
41. Herman A, Croteau G, Sekaly RP, Kappler J, Marrack P: HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells. J Exp Med 1990;172:709-717.
42. Woodland DL, Blackman MA: How do T-cell receptors, MHC molecules and superantigens get together? Immunol Today 1993;14:208-212.
43. Marsh SGE, Bodmer JG: HLA-DR and -DQ epitopes and monoclonal antibody specificity. Immunol Today 1989;10:305-312.
44. Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC: Three-dimensional structure of the human class II histocompatibility antigen HLA-DRI. Nature 1993;364:33-39.
45. Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC: Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 1996;384:134-141.
46. Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA: An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science 1996;274:209-219.
47. Fraser JD, Irving BA, Crabtree GR, Weiss A: Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 1991;251:313-316.
48. Lindsten T, June CH, Ledbetter JA, Stella G, Thompson CB: Regulation of lymphokine messenger RNA stability by a surface-mediated T-cell activation pathway. Science 1989; 244:339-343.
49. Liu Y, Linsley PS: Costimulation of T-cell growth. Curr Opin Immunol 1992;4:265-270.
50. Fraser JD, Newton ME, Weiss A: CD28 and T-cell antigen receptor signal transduction coordinately regulate interleukin-2 gene expression in response to superantigen stimulation. J Exp Med 1992;175:1131-1134.
51. Tan P, Anasetti C, Hansen JA, Melrose J, Brunvand M, Bradshaw J, Ledbetter JA, Linsley PS: Induction of alloantigen-specific hyporesponsiveness in human T-lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp Med 1993;177:165-173.
52. 2. Int Immunol 1999;11:627-633.
53. Hu H, Abedi-Valugerdi M, Möller G: Pretreatment of lymphocytes with mercury in vitro induces a response in T-cells from genetically determined low-responders and a shift of the interleukin profile. Immunology 1997;90:198-204.
54. 2 in patients with dental amalgam related contact lesions. J Oral Path Med 1999, in press.
55. Sinigaglia F: The molecular basis of metal recognition by T cells. J Invest Dermatol 1994;102:398-401.