Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover

Genetics

Volumn 153, Issue 1, 1999, Pages 35-47

  Zuk, Dorit ^a   Belk, Jonathan P ^a   Jacobson, Allan ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ALLELISM; ARTICLE; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TEMPERATURE SENSITIVITY;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CLONING, MOLECULAR; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GENETIC COMPLEMENTATION TEST; HALF-LIFE; MOLECULAR SEQUENCE DATA; MUTATION; POLYRIBOSOMES; RIBOSOMAL PROTEINS; RNA, FUNGAL; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUPPRESSION, GENETIC; TEMPERATURE; THREONINE-TRNA LIGASE;

EID: 0032832577     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. ADAM, S. A., T. NAKAGAWA, M. S. SWANSON, T. K. WOODRUFF and G. DREYFUSS, 1986 mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. Mol. Cell. Biol. 6: 2932-2943.
2. ALTSCHUL, S. F., W. GISH, W. MILLER, E. W. MYERS and D. J. LIPMAN, 1990 Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
3. ATKIN, A. L., N. ALTAMURA, P. LEEDS and M. R. CULBERTSON, 1995 The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm. Mol. Biol. Cell 6: 611-625.
4. ATKIN, A. L., L. R. SCHENKMAN, M. EASTHAM, J. N. DAHLSEID, M. J. LELIVELT et al., 1997 Relationship between yeast polyribosomes and upf proteins required for nonsense mRNA decay. J. Biol. Chem. 272: 22163-22172.
5. BECKER, D. M., and L. GUARENTE, 1991 High-efficiency transformation of yeast by electroporation. Methods Enzymol. 194: 182-187.
6. BEELMAN, C. A., and R. PARKER, 1994 Differential effects of translational inhibition in cis and trans on the decay of the unstable yeast MFA2 mRNA. J. Biol. Chem. 269: 9687-9692.
7. BEELMAN, C. A., A. STEVENS, G. CAPONIGRO, T. E. LAGRANDEUR, L. HATFIELD et al., 1996 An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature 382: 642-646.
8. BELK, J. P., F. HE and A. JACOBSON 1999 Overexpression of truncated Nmd3p inhibits protein synthesis in yeast. RNA 5: 1055-1070.
9. BOTSTEIN, D., S. C. FALCO, S. E. STEWART, M. BRENNAN, S. SCHERER et al., 1979 Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene 8: 17-24.
10. CAPONIGRO, G., and R. PARKER, 1996 Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol. Rev. 60: 233-249.
11. CARUCCIO, N., and J. ROSS, 1994 Purification of a human polyribosome-associated 3′ to 5′ exoribonuclease. J. Biol. Chem. 269: 31814-31821.
12. CUI, Y., K. W. HAGAN, S. ZHANG and S. W. PELTZ, 1995 Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translation termination codon. Genes Dev. 9: 423-436.
13. DECKER, C. J., and R. PARKER, 1993 A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev. 7: 1632-1643.
14. DECKER, C. J., and R. PARKER, 1994 Mechanisms of mRNA degradation in eukaryotes. Trends Biochem. Sci. 19: 336-340.
15. DICK, F. A., and B. L. TRUMPOWER, 1998 Heterologous complementation reveals that mutant alleles of QSR1 render 60S ribosomal subunits unstable and translationally inactive. Nucleic Acids Res. 26: 2442-2448.
16. DICK, F. A., S. KARAMANOU and B. L. TRUMPOWER, 1997 QSR1, an essential yeast gene with a genetic relationship to a subunit of the mitochondrial cytochrome bc1 complex, codes for a 60 S ribosomal subunit protein. J. Biol. Chem. 272: 13372-13379.
17. EISINGER, D. P., F. A. DICK and B. L. TRUMPOWER, 1997 Qsr1p, a 60S ribosomal subunit protein, is required for joining of 40S and 60S subunits. Mol. Cell. Biol. 17: 5136-5145.
18. HATFIELD, L., C. A. BEELMAN, A. STEVENS and R. PARKER, 1996 Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol. Cell. Biol. 16: 5830-5838.
19. HE, F., and A. JACOBSON, 1995 Identification of a novel component of the nonsense-mediated mRNA decay pathway using an interacting protein screen. Genes Dev. 9: 437-454.
20. HE, F., S. W. PELTZ, J. L. DONAHUE, M. ROSBASH and A. JACOBSON, 1993 Stabilization and ribosome association of unspliced premRNAs in a yeast upf1-mutant. Proc. Natl. Acad. Sci. USA 90: 7034-7038.
21. HE, F., A. H. BROWN and A. JACOBSON, 1997 Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol. Cell. Biol. 17: 1580-1594.
22. HENICS, T., E. NAGY and J. SZEKERES-BARTHO, 1997 Interaction of AU-rich sequence binding proteins with actin: possible involvement of the actin cytoskeleton in lymphokine mRNA turnover. J. Cell. Physiol. 173: 19-27.
23. HENNIGAN, A. N., and A. JACOBSON, 1996 Functional mapping of the translation-dependent instability element of yeast MATα1 mRNA. Mol. Cell. Biol. 16: 3833-3843.
24. HERRICK, D., R. PARKER and A. JACOBSON, 1990 Identification and comparison of stable and unstable mRNAs in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 10: 2269-2284.
25. HO, J. H., and A. W. JOHNSON, 1999 NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae. Mol. Cell. Biol. 19: 2389-2399.
26. HOLTZMAN, D. A., S. YANG and D. G. DRUBIN, 1993 Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J. Cell Biol. 122: 635-644.
27. HSU, C. L., and A. STEVENS, 1993 Yeast cells lacking 5′→3′ exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5′ cap structure. Mol. Cell. Biol. 13: 4826-4835.
28. JACOBSON, A., 1996 Poly(A) metabolism and translation: the closed loop model, pp. 451-480 in Translational Control, edited by J. HERSHEY, M. MATHEWS and N. SONENBERG. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. JACOBSON, A., and S. W. PELTZ, 1996 Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu. Rev. Biochem. 65: 693-740.
30. JIMENEZ, A., D. J. TIPPER and J. DAVIES, 1973 Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 3: 729-738.
31. JONES, J. S., and L. PRAKASH, 1990 Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast 6: 363-366.
32. KARL, T., K. ONDER, R. KODZIUS, A. PICHOVA, H. WIMMER et al., 1999 GRC5 and NMD3 function in translation control of gene expression and interact genetically. Curr. Genet. 34: 419-429.
33. KOLODZIEJ, P. A., and R.A. YOUNG, 1991 Epitope tagging and protein surveillance. Methods Enzymol. 194: 508-519.
34. KRUYS, V., O. MARINX, G. SHAW, J. DESCHAMPS and G. HUEZ, 1989 Translational blockade imposed by cytokine-derived UA-rich sequences. Science 245: 852-855.
35. LEE, B. S., and M. R. CULBERTSON, 1995 Identification of an additional gene required for eukaryotic nonsense mRNA turnover. Proc. Natl. Acad. Sci. USA 92: 10354-10358.
36. LEEDS, P., S. W. PELTZ, A. JACOBSON and M. R. CULBERTSON, 1991 The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev. 5: 2303-2314.
37. LEEDS, P., J. M. WOOD, B. S. LEE and M. R. CULBERTSON, 1992 Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol. Cell. Biol. 12: 2165-2177.
38. MANGUS, D. A., and A. JACOBSON, 1999 Linking mRNA decay and translation: assessing the polyribosomal association of decay factors and degradative intermediates. Methods 17: 28-37.
39. MARINX, O., S. BERTRAND, E. KARSENTI, G. HUEZ and V. KRUYS, 1994 Fertilization of Xenopus eggs imposes a complete translational arrest of mRNAs containing 3′UUAUUUAU elements. FEBS Lett. 345: 107-112.
40. MUHLRAD, D., and R. PARKER, 1994 Premature translational termination triggers mRNA decapping. Nature 370: 578-581.
41. MUHLRAD, D., C. J. DECKER and R. PARKER, 1994 Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to of capping followed by 5′→3′ digestion of the transcript. Genes Dev. 8: 855-866.
42. MUHLRAD, D., C. J. DECKER and R. PARKER, 1995 Turnover mechanisms of the stable yeast PGK1 mRNA. Mol. Cell. Biol. 15: 2145-2156.
43. NA, S., M. HINCAPIE, J. H. MCCUSKER and J. E. HABER, 1995 MOP2 (SLA2) affects the abundance of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. J. Biol. Chem. 270: 6815-6823.
44. NIKA, J., F. L. ERICKSON and E. M. HANNIG, 1997 Ribosomal protein L9 is the product of GRC5, a homolog of the putative tumor suppressor QM in S. cerevisiae. Yeast 13: 1155-1166.
45. PAPE, L. K., and A. TZAGOLOFF, 1985 Cloning and characterization of the gene for the yeast cytoplasmic threonyl-tRNA synthetase. Nucleic Acids Res. 13: 6171-6183.
46. PARKER, R., and A. JACOBSON, 1990 Translation and a forty-two nucleotide segment within the coding region of the mRNA encoded by the MATα1 gene are involved in promoting rapid mRNA decay in yeast. Proc. Natl. Acad. Sci. USA 87: 2780-2784.
47. PELTZ, S. W., J. L. DONAHUE and A. JACOBSON, 1992 A mutation in tRNA nucleotidyltransferase stabilizes mRNAs in Saccharomyces cerevisiae. Mol. Cell. Biol. 12: 5778-5784.
48. PELTZ, S. W., A. H. BROWN and A. JACOBSON, 1993a mRNA destabilization triggered by premature translational termination depends on three mRNA sequence elements and at least one trans-acting factor. Genes Dev. 7: 1737-1754.
49. PELTZ, S. W., C. TROTTA, H. FENG, A. BROWN, J. DONAHUE et al., 1993b Identification of the cis-acting sequences and trans-acting factors involved in nonsense-mediated mRNA decay, pp. 1-10 in Protein Synthesis and Targetting in Yeast, edited by M. TUTTE, J. MCCARTHY, A. BROWN and F. SHERMAN. Springer-Verlag, New York.
50. PELTZ, S. W., F. HE, E. WELCH and A. JACOBSON, 1994 Nonsense-mediated mRNA decay in yeast. Prog. Nucleic Acid Res. Mol. Biol. 47: 271-297.
51. RATHS, S., J. ROHRER, F. CRAUSAZ and H. RIEZMAN, 1993 end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae. J. Cell Biol. 120: 55-65.
52. REMACHA, M., A. JIMENEZ-DIAZ, C. SANTOS, E. BRIONES, R. ZAMBRANO et al., 1995 Proteins P1, P2, and P0, components of the eukaryotic ribosome stalk. New structural and functional aspects. Biochem. Cell Biol. 73: 959-968.
53. ROBERTS, D. M., L. BESL, S. H. OH, R. V. MASTERSON, J. SCHELL et al., 1992 Expression of a calmodulin methylation mutant affects the growth and development of transgenic tobacco plants. Proc. Natl. Acad. Sci. USA 89: 8394-8398.
54. ROSE, M. D., P. VOVICK, J. H. THOMAS, D. BOTSTEIN and G. R. FINK, 1987 A Saccharomyces cerevisiae genomic plasmid bank based on centromere containing shuttle vector. Gene 60: 237-243.
55. SACHS, A. B., M. W. BOND and R. D. KORNBERG, 1986 A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: domain structure and expression. Cell 45:827-835.
56. SACHS, A. B., P. SARNOW and M. W. HENTZE, 1997 Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 89: 831-838.
57. SAMBROOK, J., E. F. FRITSCH and T. MANIATIS, 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
58. SHANNON, J. M., T. PAN, K. E. EDEEN and L. D. NIELSEN, 1998 Influence of the cytoskeleton on surfactant protein gene expression in cultured rat alveolar type II cells. Am. J. Physiol. 274: L87-96.
59. SHAPIRO, R., E. A. FOX and J. F. RIORDAN, 1989 Role of lysines in human angiogenin: chemical modification and site-directed mutagenesis. Biochemistry 28: 1726-1732.
60. SHERMAN, F., G. R. FINK and J. B. HICKS, 1986 Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
61. SIKORSKI, R. S., and P. HIETER, 1989 A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
62. SONI, R., J. P. CARMICHAEL and J. A. MURRAY, 1993 Parameters affecting lithium acetate-mediated transformation of Saccharomyces cerevisiae and development of a rapid and simplified procedure. Curr. Genet. 24: 455-459.
63. VIJAYRAGHAVAN, U., M. COMPANY and J. ABELSON, 1989 Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev. 3: 1206-1216.
64. WILSON, R., R. AINSCOUGH, K. ANDERSON, C. BAYNES, M. BERKS et al., 1994 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368: 32-38.
65. ZHANG, S., E. M. WELCH, K. HAGAN, A. H. BROWN, S. W. PELTZ, et al. 1997 Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae. RNA 3: 234-244.
66. ZUK, D., and A. JACOBSON, 1998 A single amino acid substitution in yeast elF-5A results in mRNA stabilization. EMBO J. 17: 2914-2925.