Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition

Brain Research

Volumn 843, Issue 1-2, 1999, Pages 48-52

  Thomas, Ajit G ^a   Olkowski, Jennifer L ^a   Vornov, James J ^a   Slusher, Barbara S ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

2 PMPA; In vitro; Methotrexate hexaglutamate; NAALADase; Neurotoxicity

Indexed keywords

DIPEPTIDASE; DIZOCILPINE; FOLIC ACID; METHOTREXATE POLYGLUTAMATE; PTEROPTIN; TENOFOVIR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; BENZOATES; CARBOXYPEPTIDASES; CELLS, CULTURED; CEREBRAL CORTEX; DEOXYGLUCOSE; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; FETUS; GLUTAMATE CARBOXYPEPTIDASE II; GLYCINE; METHOTREXATE; N-METHYLASPARTATE; NEURONS; NEUROTOXINS; ORGANOPHOSPHORUS COMPOUNDS; POTASSIUM CYANIDE; PYRROLIDINES; RATS;

EID: 0032832469     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01879-X     Document Type: Article

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