Polarized expression of immunoglobulin, spectrin, and protein kinase C beta II occurs in B cells from normal BALB/c, autoimmune lpr, and anti-ssDNA transgenic, tolerant mice

Journal of Leukocyte Biology

Volumn 66, Issue 4, 1999, Pages 617-624

  Masso Welch, Patricia A ^a   Black, Jennifer D ^a   Erikson, Jan ^b   Repasky, Elizabeth A ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

Ankyrin; diI; Immune response

Indexed keywords

ANKYRIN; DNA; IMMUNOGLOBULIN; PROTEIN KINASE C; SPECTRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CAPPING PHENOMENON; CELL MEMBRANE; CELL POLARITY; CELL STIMULATION; CELL SUBPOPULATION; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

ANIMALIA;

EID: 0032832351     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.4.617     Document Type: Article

References (33)

1. Schreiner, G. F., Unanue, E. R. (1977) Capping and the lymphocyte: Models for membrane reorganization. J. Immunol. 119, 1549-1551.
2. Braun, J., Unanue, E. R. (1983) The lymphocyte cytoskeleton and its control of surface receptor functions. Semin. Hematol. 20, 322-333.
3. Bretscher, M. S. (1996) Getting membrane flow and the cytoskeleton to cooperate in moving cells. Cell 87, 601-606.
4. Levine, J., Willard, M. (1983) Redistribution of fodrin (a component of the cortical cytoskeleton) accompanying capping of cell surface molecules. Proc. Natl. Acad. Sci. USA 80, 191-195.
5. Nelson, W. J., Calaco, C. A., Lazarides, E. (1983) Involvement of spectrin in cell-surface receptor capping in lymphocytes. Proc. Natl. Acad. Sci. USA 80, 1626-1630.
6. Braun, J., Fujiwara, K., Pollard, T. D., Unanue, E. R. (1978) Two mechanisms for the redistribution of lymphocyte surface macromolecules. I. Relationship to cytoplasmic myosin. J. Cell Biol. 79, 409-418.
7. Gabbiani, G., Chaponnier, C., Zumbe, A., Vassalli, P. (1977) Actin and tubulin co-cap with surface immunoglohulin in mouse B lymphocytes. Nature 269, 697-698.
8. Flanagan, J., Koch, G. L. (1978) Cross-linked surface Ig attaches to actin. Nature 273, 278-281.
9. Gupta, S. K., Woda, B.A. (1988) Ligand-induced association of surface immunoglobulin with the detergent-insoluble cytoskeleton may involve alpha-actinin. J. Immunol. 140, 176-182.
10. Yakara, I., Kakimoto-Sameshima, F. (1978) Microtubule organization of lymphocytes and its modulation by patch and cap formation. Cell 15. 251-259.
11. Dellagi, K., Brouet, J. C. (1982) Redistribution of intermediate filaments during capping of lymphocyte surface molecules. Nature 298, 284-286.
12. Lee, J. K., Repasky, E. A. (1984) Cytoskeletal polarity in mammalian lymphocytes in situ. Cell Tissue Res. 247, 195-202.
13. Carraway, K. L., Carraway, C. A. (1994) Signaling, mitogenesis and the cytoskeleton: where the action is. Bioessays 17, 171-175.
14. Nishizuka, Y. (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
15. Kupfer, A., Singer, S. J. (1989) The specific interaction of T helper cells and antigen presenting cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose. J. Exp. Med. 170, 1697-1713.
16. Kupfer, H., Monks, C. R., Kupfer, A. (1994) Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescent microscopic studies of Th-B antigen-presenting cell interactions. J. Exp. Med. 179, 1507-1515.
17. Geiger, B., Rosen, D., Berke, G. (1982) Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells. J. Cell Biol. 95, 137-143.
18. Kupfer, A., Dennert, G. (1984) Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic T lymphocytes triggered by binding to lysable target cells. J. Immunol. 133, 2762-2766.
19. Kupfer, A., Singer, S. J., Dennert, G. (1986) On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. J. Exp. Med. 163, 489-498.
20. Cohen, P. L., Eisenberg, R. A. (1991) Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9, 243-269.
21. Erikson, J., Radic, M. Z., Camper, S. A., Hardy, R. R., Carmack, C., Weigert, M. (1991) Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349, 331-334.
22. Nguyen, K-A. T., Mandik, L., Bui, A., Kavaler, J., Norvell, A., Monroe, J. G., Roark, J. H., Erikson, J. (1997) Characterization of anti-single-stranded DNA B cells in a non-auto-immune background. J. Immunol. 159, 2633-2644.
23. Gregorio, C. C., Kubo, R. T., Bankert, R. B., Repasky, E. A. (1992) Translocation of spectrin and protein kinase C to a cytoplasmic aggregate upon lymphocyte activation. Proc. Natl. Acad. Sci. USA 89, 4947-4951.
24. Thomas, J. L., Holowka, D., Baird, B., Webb, W. W. (1994) Large-scale co-aggregation of fluorescent lipid probes with cell surface proteins. J. Cell Biol. 125, 795-802.
25. Gregorio, C. C., Repasky, E. A., Fowler, V. M., Black, J. D. (1994) Dynamic properties of ankyrin in T lymphocytes: Colocalization with spectrin and PKC-beta. J. Cell Biol. 125, 345-358.
26. Nishizuka, Y. (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9, 484-496.
27. Edidin, M., Stroynowski, I. (1991) Differences between the lateral organization of conventional and inositol phospholipid-anchored membrane proteins. A further definition of micrometer scale membrane domains. J. Cell Biol. 112, 1143-1150.
28. Scher, M. G., Bloch, R. J. (1991) The lipid bilayer of acetylcholine receptor clusters of cultured rat myotubes is organized into morphologically distinct domains. Exp. Cell Res. 195, 79-91.
29. Singer, S. J., Kupfer, A. (1986) The directed migration of eukaryotic cells. Annu. Rev. Cell Biol. 2, 337-365.
30. Wang, X-Y., Ostberg, J. R., Repasky, E. A. (1999) Effect of fever-like whole body hyperthermia on lymphocyte spectrin distribution, protein kinase C activity and uropod formation. J. Imniunol. in press.
31. Del Pozo, M. A., Sanchez-Mateos, P., Sanchez-Madrid, F. (1996) Cellular polarization induced by cliemokines: a mechanism for leukocyte recruitmenl? Immunol. Today 17, 127-131.
32. Mosbach-Ozraan, L., Humez, S., Fonteneau, P., Loor, F. (1986) Increased membrane immunoglobulin capping of B cells from C57B1/6 lpr/lpr and C57B1/6 nulnu mice. Cell. Immunol. 98, 517-524.
33. Metzger. H. (1992) Transmembrane signaling: the joy of aggregation. J. Immunol. 149, 1477-1487.