The profile of FR140423, a novel anti-inflammatory compound, in yeast-induced rat hyperalgesia

Japanese Journal of Pharmacology

Volumn 81, Issue 1, 1999, Pages 94-98

  Ochi, Takehiro ^a   Fujii, Takashi ^a   Motoyama, Yukio ^a   Goto, Toshio ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

FR140423; Opioid; Prostaglandin formation; Yeast induced hyperalgesia

Indexed keywords

3 (DIFLUOROMETHYL) 1 (4 METHOXYPHENYL) 5 [4 (METHYLSULFINYL)PHENYL]PYRAZOLE; ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID DERIVATIVE; INDOMETACIN; LEUKOTRIENE B4; MORPHINE; NALOXONE; OPIATE RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN INHIBITOR; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; HYPERALGESIA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; YEAST;

ANALGESICS, OPIOID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERALGESIA; INDOMETHACIN; INJECTIONS, SUBCUTANEOUS; MALE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; SACCHAROMYCES CEREVISIAE; SULFOXIDES;

EID: 0032831638     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.81.94     Document Type: Article

References (18)

1. Tsuji K, Konishi N, Spears GW, Ogino T, Nakamura K, Tojo T, Ochi T, Shimojo F, Senoh H and Matsuo M: Studies on anti-inflammatory agents. V. Synthesis and pharmacological properties of 3-(difluromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl]pyrazole and related compounds. Chem Pharm Bull (Tokyo) 45, 1475-1481 (1997)
2. Ochi T, Jobo-Magari K, Yonezawa A, Matsumori K and Fujii T: Anti-inflammatory and analgesic effects of a novel pyrazole derivative, FR140423. Eur J Pharmacol 365, 259-266 (1999)
3. Randall LO and Selitto JJ: A method for measurment of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 111, 409-419 (1957)
4. Opas EE, Dallob A, Herold E, Luell S and Humes JL: Pharmacological modulation of eicosanoid levels and hyperalgesia in yeast-induced inflammation. Biochem Pharmacol 36, 547-551 (1987)
5. Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 231, 232-235 (1971)
6. Pasternak GW: Pharmacological mechanisms of opioid analgesics. Clin Neuropharmacol 16, 1-18 (1993)
7. Zimmermann M: Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16, 109-110 (1983)
8. Powell WS: Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. Prostaglandins 20, 947-957 (1980)
9. Powell WS: Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica. Methods Enzymol 86, 467-477 (1982)
10. Litchfield JT Jr and Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96, 99-113 (1949)
11. Dubinsky B, Gebre-Mariam S, Capetola RJ and Rosenthale ME: The antialgesic drugs: human therapeutic correlates of their potency in laboratory animal models of hyperalgesia. Agents Actions 20, 50-60 (1987)
12. Carey F and Haworth D: Temporal studies of the formation of cyclo-oxygenase and lipoxygenase metabolites in yeast-induced inflammation. Br J Pharmacol 85, 271P (1985)
13. Carey F and Haworth D: Effect of the mixed cyclo-oxygenase/5-lipoxygenase inhibitor, BW755C in a model of yeast-induced inflammation. Br J Pharmacol 86, 652P (1985)
14. 2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3, 353-357 (1973)
15. 4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes. Science 225, 743-745 (1984)
16. Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H and Otomo S: NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol 24, 105-110 (1993)
17. Matsushita M, Masaki M, Yagi Y, Tanaka Y and Wakitani K: Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats. Inflamm Res 46, 461-466 (1997)
18. Belanger P, Maycock A, Guindon Y, Bach T, Dollob AL, Dufresne C, Ford-Hutchinson AW, Gale PH, Hopple S, Lau CK, Letts LG, Luell S, McFarlane CS, MacIntyre E, Meurer R, Miller DK, Piechuta H, Riendeau D, Rpkach J, Pouzer C and Scheigetz J: L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3-methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor. Can J Physiol Pharmacol 65, 2441-2448 (1987)