Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig

Canadian Journal of Physiology and Pharmacology

Volumn 77, Issue 4, 1999, Pages 259-267

  Lasley, Robert D ^a,b   Randhawa Jr , Mohinder P S ^a   Hegge, Julia O ^a   Mentzer Jr , Robert M ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Acadesine; Adenosine; Interstitial fluid; Microdialysis; Myocardial stunning

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE; NUCLEOSIDE; PENTOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE FUNCTION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; STUNNED HEART MUSCLE; SWINE;

EID: 0032831609     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y99-023     Document Type: Article

References (41)

1. Ambrosio, G., Jacobus, W.E., Mitchell, M.C., Litt, M.R., and Becker, LC. 1989. Effects of ATP precursors on ATP and free ADP content and functional recovery of postischemic hearts. Am. J. Physiol. 256: H560-H566.
2. Auchampach, J.A., Rizvi, A., Qiu, Y., Tang, X.L., Maldonado, C., Teschner, S., and Bolli, R. 1997. Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl)adenosine-5′-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits. Circ. Res. 80: 800-809.
3. Clanachan, A.S., Heaton, T.P., and Parkinson, F.E. 1987. Drug interactions with nucleoside transport systems. In Topics and perspectives in adenosine research. Edited by E. Gerlach and B.F. Becker. Springer-Verlag, Berlin. pp. 118-130.
4. Deussen, A., Walter, C., Borst, M., and Schrader, J. 1991. Transmural gradient of adenosine in canine heart during functional hyperemia. Am. J. Physiol. 260: H671-H680.
5. Dixon, R., Fujitaki, J., Chrastil, L., and Lee, J. 1989. AICA-riboside: direct quantitation in ultrafiltrates of plasma by HPLC during pharmacokinetic studies in man. Res. Commun. Chem. Pathol. Pharmacol. 65: 405-408.
6. Dorheim, T.A., Hoffman, A., Van Wylen, D.G.L., and Mentzer, R.M., Jr. 1991. Enhanced interstitial fluid adenosine attenuates myocardial stunning. Surgery, 110: 136-145.
7. Dorion, M., Rouleau, J., and Kingma, J.G., Jr. 1992. Failure of AICA riboside to limit infarct size during acute myocardial infarction in rabbits. J. Cardiovasc. Pharmacol. 19: 69-77.
8. Galiñanes, M., Mullane, K.M., Bullough, D., and Hearse, D.J. 1992. Acadesine and myocardial protection: studies of time of administration and dose-response relations in the rat. Circulation, 86: 598-608.
9. Glower, D.D., Spratt, J.A., Newton, J.R., Wolfe, J.A., Rankin, J.S., and Swain, J.L. 1987. Dissociation between early recovery of regional function and purine nucleotide content in postischemic myocardium in the conscious dog. Cardiovasc. Res. 21: 328-336.
10. Gruber, H.E., Hoffer, M.E., McAllister, D.R., Laikind, P.K., Lane, T.A., Schmid-Schoenbein, G.W., and Engler, R.L. 1989. Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury. Circulation, 80: 1400-1411.
11. Hoffmeister, H.M., Mauser, M., and Schaper, W. 1985. Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium. Basic Res. Cardiol. 80: 445-458.
12. Hudspeth, D.A., Williams, M.W., Zhao, Z.Q., Sato, H., Nakanishi, K., McGee, D.S., Hammon, J.W., Jr., Vinten-Johansen, J., and Van Wylen, D.G.L. 1994. Pentostatin-augmented interstitial adenosine prevents postcardioplegia injury in damaged hearts. Ann. Thorac. Surg. 58: 719-727.
13. Kingma, J.G., Jr., Simard, D., and Rouleau, J.R. 1994. Timely administration of AICA riboside reduces reperfusion injury in rabbits. Cardiovasc. Res. 28: 1003-1007.
14. Kirkeboen, K.A., Ilebekk, A., Tonnessen, T., Leistad, E., Naess, P.A., Christensen, G., and Aksnes, G. 1994. Cardiac contractile function following repetitive brief ischemia: effects of nucleoside transport inhibition. Am. J. Physiol. 267: H57-H65.
15. Kurz, M.A., Bullough, D.A., Bugge, C.J.L., Mullane, K.M., and Young, M.A. 1997. Cardioprotection with a novel adenosine regulating agent mediated by intravascular adenosine. Eur. J. Pharmacol. 322: 211-220.
16. 1 receptor mechanism. Am. J. Physiol. 263: H1460-H1465.
17. Lasley, R.D., Hegge, J.O., Noble, M.A., and Mentzer, R.M., Jr. 1998. Comparison of interstitial fluid and coronary venous adenosine levels in in vivo porcine myocardium. J. Mol. Cell. Cardiol. 30: 1137-1147.
18. Lopaschuk, G.D. 1997. Alterations in fatty acid oxidation during reperfusion of the heart after myocardial ischemia. Am. J. Cardiol. 80: 11A-16A.
19. Martin, B.J., Lasley, R.D., and Mentzer, R.M., Jr. 1997a. Infarct size reduction with the nucleoside transport inhibitor R75231 in swine. Am. J. Physiol. 272: H1857-H1865.
20. Martin, B.J., McClanahan, T.B., Van Wylen, D.G., and Gallagher, K.P. 1997b. Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial adenosine levels and infarct size. Basic Res. Cardiol. 92: 240-251.
21. Mauser, M., Hoffmeister, H.M., Nienaber, C., and Schaper, W. 1985. Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog. Circ. Res. 56: 220-230.
22. Meghji, P., Middleton, K.M., and Newby, A.C. 1988. Absolute rates of adenosine formation during ischaemia in rat and pigeon hearts. Biochem. J. 249: 695-703.
23. Mentzer, R.M., Jr., Ely, S.W., Lasley, R.D., and Berne, R.M. 1988. The acute effects of AICAR on purine nucleotide metabolism and postischemic cardiac function. J. Thorac. Cardiovasc. Surg. 95: 286-293.
24. Merrill, G.F., Kurth, E.J., Hardie, D.G., and Winder, W.W. 1997. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol. 273: E1107-E1112.
25. Mitsos, S.E., Jolly, S.R., and Lucchesi, B.R. 1985. Protective effects of AICA riboside in the globally ischemic isolated cat heart. Pharmacology, 31: 121-131.
26. Mullane, K., and Young, M. 1993. Acadesine: prototype adenosine regulating agent for treating myocardial ischemia-reperfusion injury. Drug Dev. Res. 28: 336-343.
27. Mullane, K., Bullough, D., and Shapiro, D. 1993. From academic vision to clinical reality: a case study of acadesine. Trends Cardiovasc. Med. 3: 227-234.
28. Nees, S., Herzog, V., Becker, B.F., Bock, M., Des Rosiers, C., and Gerlach, E. 1985. The coronary endothelium: a highly active metabolic barrier for adenosine. Basic Res. Cardiol. 80: 515-529.
29. Ngai, A.C., Monsen, M.R., Ibayashi, S., Ko, K.R., and Winn, H.R. 1989. Effect of inosine on pial arterioles: potentiation of adenosine-induced vasodilation. Am. J. Physiol. 256: H603-H606.
30. Randhawa, M.P.S., Jr., Lasley, R.D., and Mentzer, R.M., Jr. 1995. Salutary effects of exogenous adenosine on in vivo myocardial stunning. J. Thorac. Cardiovasc. Surg. 110: 63-74.
31. Sabina, R.L., Kernstine, K.H., Boyd, R.L., Holmes, E.W., and Swain, J.L. 1982. Metabolism of 5-amino-4-imidazole-carboxamide riboside in cardiac and skeletal muscle. J. Biol. Chem. 257: 10178-10183.
32. Sekili, S., Jeroudi, M.O., Tang, X.L., Zughaib, M., Sun, J.Z., and Bolli, R. 1995. Effect of adenosine on myocardial "stunning" in the dog. Circ. Res. 76: 82-94.
33. Smits, G.J., McVey, M., Cox, B.F., Perrone, M.H., and Clark, K.L. 1998. Cardioprotective effects of the novel adenosine A1/A2 receptor agonist AMP 579 in a porcine model of myocardial infarction. J. Pharmacol. Exp. Ther. 286: 611-618.
34. Tsuchida, A., Yang, X.M., Burckhartt, B., Mullane, K.M., Cohen, M.V., and Downey, J.M. 1994. Acadesine extends the window of protection afforded by ischaemic preconditioning. Cardiovasc. Res. 28: 379-383.
35. Van Belle, H. 1969. Uptake and deamination of adenosine by blood-species differences, effect of pH, ions, temperature and metabolic inhibitors. Biochem. Biophys. Acta, 192: 124-132.
36. Van Wylen, D.G.L., Willis, J., Sodhi, J., Weiss, R.J., Lasley, R.D., and Mentzer, R.M., Jr. 1990. Cardiac microdialysis to estimate interstitial adenosine and coronary blood flow. Am. J. Physiol. 258: H1642-H1649.
37. Vinten-Johansen, J., Nakanishi, K., Zhao, Z.Q., McGee, D.S., and Tan, P. 1993. Acadesine improves surgical myocardial protection with blood cardioplegia in ischemically injured canine hearts. Circulation, 88: 350-358.
38. Wang, T., Mentzer, R.M., Jr., and Van Wylen, D.G.L. 1992. Interstitial adenosine with dipyridamole: effect of adenosine receptor blockade and adenosine deaminase. Am. J. Physiol. 263: H552-H558.
39. 1 receptor-mediated cardioprotection in stunned canine myocardium. Circulation, 88: 235-244.
40. Young, M.A., Mazur, C., and Mullane, K. 1994. Acadesine attenuates ischemic cardiac dysfunction in the isolated blood-perfused rabbit heart. Drug Dev. Res. 31: 157-163.
41. Zhao, Z., Williams, M.W., Sato, H., Hudspeth, D.A., McGee, D.S., Vinten-Johansen, J., and Van Wylen, D.G. 1995. Acadesine reduces myocardial infarct size by an adenosine mediated mechanism. Cardiovasc. Res. 29: 495-505.