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Volumn 55, Issue 2, 1999, Pages 471-491

Genetics in drug discovery and development: Challenge and promise of individualizing treatment in common complex diseases

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE DRUG REACTION; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG TOLERABILITY; GENETIC PREDISPOSITION; GENETICS; INHERITANCE; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW;

EID: 0032831381     PISSN: 00071420     EISSN: None     Source Type: Journal    
DOI: 10.1258/0007142991902385     Document Type: Review
Times cited : (27)

References (9)
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  • 2
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    • Analysis of risk factors for stroke in a cohort of men born in 1913
    • Welin-L, Svardsudd-K, Wilhelmsen-L, Larsson-B, Tibblin-G. Analysis of risk factors for stroke in a cohort of men born in 1913. N Engl J Med 1987; 317: 521-6
    • (1987) N Engl J Med , vol.317 , pp. 521-526
  • 3
    • 0017166727 scopus 로고
    • Familial aggregation of blood pressure in 558 adopted children
    • Biron P, Mongeau JG, Bertrand D. Familial aggregation of blood pressure in 558 adopted children. Can Med Assoc J 1976; 115: 773-4
    • (1976) Can Med Assoc J , vol.115 , pp. 773-774
    • Biron, P.1    Mongeau, J.G.2    Bertrand, D.3
  • 4
    • 0030820532 scopus 로고    scopus 로고
    • Genetics of asthma: The university of toronto program
    • Slutsky AS, Zamel N. Genetics of asthma: the University of Toronto Program. Am J Respir Crit Care Med 1997; 156: S130-2
    • (1997) Am J Respir Crit Care Med , vol.156
    • Slutsky, A.S.1    Zamel, N.2
  • 5
    • 0018853224 scopus 로고
    • Genetic variability of HLA in the dariusleut hutterites. A comparative genetic analysis of the hutterities, the Amish, and other selected Caucasian populations
    • Morgan K, Holmes TM, Schlaut J et al. Genetic variability of HLA in the Dariusleut Hutterites. A comparative genetic analysis of the Hutterities, the Amish, and other selected Caucasian populations. Am J Hum Genet 1980; 32: 246-57
    • (1980) Am J Hum Genet , vol.32 , pp. 246-257
    • Morgan, K.1    Holmes, T.M.2    Schlaut, J.3
  • 6
    • 0033560279 scopus 로고    scopus 로고
    • As consortium plans free SNP map of human genome
    • Masood E. As consortium plans free SNP map of human genome [news]. Nature 1999; 398: 545-6
    • (1999) Nature , vol.398 , pp. 545-546
    • Masood, E.1
  • 7
    • 0007691164 scopus 로고
    • Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease
    • Poirier J, Delisle CM, Quirion R et al. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proc Natl Acad Sci USA 1995; 92: 12260-4,
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12260-12264
    • Poirier, J.1    Delisle, C.M.2    Quirion, R.3
  • 8
    • 0031943549 scopus 로고    scopus 로고
    • Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease
    • Farlow MR, Lahiri DK, Poirier J, Davignon J, Schneider L, Hui SL. Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease. Neurology 1998; 50: 669-77
    • (1998) Neurology , vol.50 , pp. 669-677
    • Farlow, M.R.1    Lahiri, D.K.2    Poirier, J.3    Davignon, J.4    Schneider, L.5    Hui, S.L.6
  • 9
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    • The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis
    • The Regression Growth Evaluation Statin Study Group
    • Kuivenhoven JA, Jukema JW, Zwinderman AH et al. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. N Engl J Med 1998; 338; 86-93
    • (1998) N Engl J Med , vol.338 , pp. 86-93
    • Kuivenhoven, J.A.1    Jukema, J.W.2    Zwinderman, A.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.