Preparation and in vitro antibacterial activity of 6-O-methylerythromycin D

Journal of Antibiotics

Volumn 52, Issue 9, 1999, Pages 831-834

  Gracey, H Eugene ^a   Montgomery, Stephen H ^a   Liu, Jih Hua ^a,b   Nilius, Angela ^b   Celebuski, Joseph E ^a  

^a Chem and Agric Products Division   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLARITHROMYCIN; ERYTHROMYCIN; ERYTHROMYCIN DERIVATIVE;

ANTIBACTERIAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NOTE; PRIORITY JOURNAL;

EID: 0032830922     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.52.831     Document Type: Note

References (6)

1. MORIMOTO, S.; Y. TAKAHASHI, Y. WATANABE & S. OMURA: Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-0-methyl-erythromycins A. J. Antibiotics 37: 187-189, 1984
2. MORIMOTO, S.; Y. MISAWA, T. ADACHI, T. NAGATE, Y. WATANABE & S. OMURA: Chemical modification of erythromycins. II. Synthesis and antibacterial activity of O-alkyl derivatives of erythromycin A. J. Antibiotics 43 : 286∼294, 1990
3. MAJER, J.; J. R. MARTIN, R. S. EGAN & J. W. CORCORAN: Antibiotic glycosides. 8. Erythromycin D, a new antibiotic. J. Am. Chem. Soc. 99: 1620∼1622, 1977
4. HAUSKE, J. R.; M. GUADLIANA, G. KOSTEK & G. SCHULTE: Aglycon modifications of erythromycin A: Regiospecific and stereospecific elaboration of the C-12 position. J. Org. Chem. 52: 4622∼4625, 1987
5. WADDELL, S. T. & T. A. BLIZZARD: Base catalyzed ring opening reactions of erythromycin A. Tetrahedron Letters 33: 7827∼7830, 1992
6. LIU, J.-H. & J. E. CELEBUSKI: 6-O-Methylerythromycin D and process for making same. U. S. Patent 5,756,473, May 26, 1998