Reduction of tablet coloration at tableting for oily medicine (tocopheryl nicotinate)

International Journal of Pharmaceutics

Volumn 187, Issue 1, 1999, Pages 125-135

  Takashima, Yuki ^a   Yuasa, Hiroshi ^a   Kanaya, Yoshio ^a   Nomura, Izuru ^b   Shinozawa, Kazuya ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b Takeshima Pharmaceutical Co   (Japan)

Author keywords

Calcium silicate; Coloration; Compression; Oily medicine; Tablet; Tocopheryl nicotinate

Indexed keywords

AEROSIL; ALPHA TOCOPHEROL NICOTINATE; FLORITE; SILICATE; UNCLASSIFIED DRUG;

ARTICLE; COLOR; CRUSHING STRENGTH; DENSITY; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET DISINTEGRATION; TABLET MANUFACTURE;

ANTIHYPERTENSIVE AGENTS; CALCIUM COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; COLOR; COMPRESSIVE STRENGTH; DRUG CARRIERS; NICOTINIC ACIDS; POROSITY; POWDERS; SILICATES; SILICON DIOXIDE; TABLETS; TENSILE STRENGTH; VITAMIN E;

EID: 0032830863     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00179-9     Document Type: Article

References (7)

1. JIS Z-8730, 1980. Method for specification of colour differences for opaque materials.
2. Kimura T., Fukui E., Kageyu A., Kurohara H., Kurosaki Y., Nakayama T., Morita Y., Shibusawa K., Ohsawa S., Takeda Y. Enhancement of oral bioavailability of D-α-tocopherol acetate by lecithin-dispersed aqueous preparation containing medium-chain triglycerides in rats. Chem. Pharm. Bull. 37:1989;439-441.
3. Takeuchi H., Sasaki H., Niwa T., Hino T., Kawashima Y., Uesugi K., Ozawa H. Redispersible dry emulsion system as novel oral dosage form of oily drugs: in vivo studies in beagle dogs. Chem. Pharm. Bull. 39:1991;3362-3364.
4. Takeuchi H., Sasaki H., Niwa T., Hino T., Kawashima Y., Uesugi K., Ozawa H. Design of redispersible dry emulsion as an advanced dosage form of oily drug (vitamin E nicotinate) by spray-drying technique. Drug Dev. Ind. Pharm. 18:1992;919-937.
5. Yuasa H., Asahi D., Takashima Y., Kanaya Y., Shinozawa K. Application of calcium silicate for medicinal preparation. I. Solid preparation adsorbing an oily medicine to calcium silicate. Chem. Pharm. Bull. 42:1994;2327-2331.
6. Yuasa H., Takashima Y., Kanaya Y., Kano K., Uchida Y. The coloration of many kinds of commercial tablets by exposure to light and coexistence with BHT. Jpn. J. Hosp. Pharm. 21:1995;231-242.
7. Yuasa H., Akutagawa M., Hashizume T., Kanaya Y. Studies on internal structure of tablets. VI. Stress dispersion in tablets by excipients. Chem. Pharm. Bull. 44:1996;378-382.