Changes in airway dead space in response to methacholine provocation in normal subjects

Clinical Physiology

Volumn 19, Issue 5, 1999, Pages 426-432

  Olsson, K ^a   Greiff, L ^a   Karlefors, F ^a   Johansson, S ^a   Wollmer, P ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bronchial provocation test; Capnography; Carbon dioxide; Methacholine chloride; Respiratory dead space

Indexed keywords

CARBON DIOXIDE; METHACHOLINE;

ADULT; AIRWAY; ARTICLE; BREATHING; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; DOSE RESPONSE; DOSIMETRY; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN EXPERIMENT; LUNG ALVEOLUS; LUNG DEAD SPACE; NORMAL HUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SPIROMETRY; TIDAL VOLUME;

ADOLESCENT; ADULT; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; METHACHOLINE CHLORIDE; MIDDLE AGED; MUSCARINIC AGONISTS; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; RESPIRATORY DEAD SPACE;

EID: 0032830072     PISSN: 01445979     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2281.1999.00197.x     Document Type: Article

References (21)

1. 2 analysis: description and validation of a method. Crit Care Med, 24, 96-102.
2. BEACH J. R., STENTON S. C., CONNOLLY M. J., WALTERS E. H. & HENDRICK D. J. (1995) Effects of diurnal variation and prolonged refractoriness on repeated measurements of airway responsiveness to mechacholine. Thorax, 50, 235-239.
3. BENSON M. K. (1975) Bronchial hyperreactivity. Br J Dis Chest, 69, 227-239.
4. BERGLUND E., BIRATH G., BJURE J., GRIMBY G., KJELLMER I., SANDQVIST L. & SODERHOLM B. (1963) Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age. Acta Med Scand, 173, 185-192.
5. FLETCHER R. & JONSON B. (1984) Deadspace and the single breath test for carbon dioxide during anaesthesia and artificial ventilation. Br J Anaesth, 56, 109-119.
6. FLETCHER R., JONSON B., CUMMING G. & BREW J. (1981) The concept of deadspace with special reference to the single breath test for carbon dioxide. Br J Anaesth, 53, 77-88.
7. HENSLEY M. J., O'CAIN C. H., MCFADDEN E. R. & INGRAM R. H. (1978) Distribution of bronchodilatation in normal subjects: beta agonist versus atropine. J Appl Physiol, 45, 778-782.
8. 2 contents in expired air (capnography) in the inhalative provocation of children. I. Acetylcholine provocation of school-age children. Acta Paediatr Acad Sci Hung, 10, 133-154.
9. 2 contents in expired air (capnography) in the inhalative provocation of children. II. Acetylcholine provocation of asthmatic children under seven years of age. Acta Paediatr Acad Sci Hung, 10, 155-159.
10. 2 analyzer. Br J Anaesth, 52, 491-498.
11. PEDLEY T. J., SCHROTER R. C. & SUDLOW M. F. (1970) The prediction of pressure drop and variation of resistance within the human bronchial airways. Respir Physiol, 9, 387-405.
12. PELLEGRINO R., VIOLANTE E. & BRUSASCO V. (1996) Maximal bronchoconstriction in humans. Relationship to deep inhalation and airway sensitivity. Am J Respir Crit Care Med, 153, 115-121.
13. QUANJER P. H. H., TAMMELING G. J., COTES J. E., PEDERSEN O. F., PESLIN R. & YERNAULT J. C. (1993) Lung volumes and forced ventilatory flows. Eur Respir J, 6 (Suppl. 16), 5-40.
14. SCHMEKEL B., HEDENSTROM H., KAMPE M., LAGERSTRAND L., STÂLENHEIM G., WOLLMER P. & HEDENSTIERNA G. (1994) The bronchial response to inhaled methacholine is dependent on the aerosol deposition pattern. Chest, 106, 1781-1787.
15. SEPCR WORKING GROUP 'BRONCHIAL HYPERREACTIVITY' (1983) Guidelines for standardization of bronchial challenges with (nonspecific) bronchoconstricting agents. Bull Eur Physiopathol Respir, 19, 495-514.
16. WEERSINK E. J. M., ELSHOUT F. J. J. V., HERWAARDEN C. & FOLGERING H. (1995) Bronchial responsiveness to histamine and methacholine measured with forced expirations and with the forced oscillation technique. Respir Med, 89, 351-356.
17. WEIBEL E. R. (1963) Morphometry of the Human Lung Springer Verlag, Berlin.
18. WILSON J. W., Li X. & PAIN M. C. F. (1993) The lack of distensibility of asthmatic airways. Am Rev Respir Dis, 148, 806-809.
19. WOLFF G. & BRUNNER J. X. (1984) Series dead space volume assessed as the mean value of a distribution function. Int J Clin Monit Comput, 1, 177-181.
20. YARON M., PADYK P., HUTSINPILLER M. & CAIRNS C. B. (1996) Utility of the expiratory capnogram in the assessment of bronchospasm. Ann Emerg Med, 28, 403-407.
21. YOU B., MAYEUX D., RKIEK, B., AUTRAN N., DANG VU V. & GRILLIAT J. P. (1992) Expiratory capnography in asthma. Perspectives in the use and monitoring in children. Rev Mal Respir, 9, 547-552.