Transcytotic vesicle fusion is reduced in cholestatic rats: Redistribution of phospholipids in the canalicular membrane

Digestive Diseases and Sciences

Volumn 44, Issue 8, 1999, Pages 1662-1668

  Hyogo, Hideyuki ^a   Tazuma, Susumu ^a   Kajiyama, Goro ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Bile; Cholestasis; Fusion; Membrane; Phospholipid

Indexed keywords

CHOLESTEROL; FATTY ACID; LIPOSOME; MEMBRANE PHOSPHOLIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE; CHOLESTASIS; CONTROLLED STUDY; LIPID COMPOSITION; LIPID TRANSPORT; MALE; MEMBRANE FLUIDITY; MEMBRANE VESICLE; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RAT;

ANIMALS; BILE CANALICULI; CHOLESTASIS; CHOLESTEROL; FATTY ACIDS; LIPOSOMES; MALE; MEMBRANE FUSION; MEMBRANES; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOMYELINS; TISSUE DISTRIBUTION;

EID: 0032829697     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026639716440     Document Type: Article

References (44)

1. Coleman R, Bell RM: Evidence that biosynthesis of phosphatidylethanolamine, phosphatidylcholine, and triacylglycerol occurs on the cytoplasmic side of microsomal vesicles. J Cell Biol 76:245-253, 1978
2. Crawford JM, Berken CA, Gollan JL: Role of the hepatocyte microtubular system in excretion of bile salts and biliary lipid: Implications for intracellular vesicular transport. J Lipid Res 29:144-156, 1988
3. Gregory DH, Vlaheevic ZR, Prugh MF, Swell L: Mechanism of secretion of biliary lipids: role of a microtubular system in hepatocellular transport of biliary lipids in the rat. Gastroenterology 74:93-100, 1978
4. Crawford JM, Gollan JL: hepatocyte cotransport of taurocholate and bilirubin glucuronidases: Role of microtubules. Am J Physiol Soc 255:G121-G131, 1988
5. Cohen DE, Leonard MR, Carey MC: In vitro evidence that phospholipid secretion into bile may be coordinated intracellulary by the combined action of bile salts and the specific phosphatidylcholine transfer protein of liver. Biochemistry 33:9975-9980, 1994
6. Smit JJM, Schinkel AH, Oude Elferink RPJ, Groen AK, Wagenaar E, Van Deemter L, Mol CAAM, Ottenhoff R, Van der Lugt NMT, van Roon MA, Van der Volk MA, Offerhaus GJA, Berns AJM, Borst P: Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75:451-462, 1993
7. Oude Elferink RPJ, Tytgat GNJ, Groen AK: The role of mdr2 P-glycoprotein in hepatobiliary lipid transport. FASEB J 11:19-28, 1097
8. Konikoff FM, Cohen DE, Cary MC: Phospholipid molecular species influence crystal habits and transition sequences of metastable intermediates during cholesterol crystallization from bile salts-rich model bile. J Lipid Res 35:60-70, 1994
9. Tazuma S, Ochi H, Teramen K, Yamashita Y, Horikawa K, Miura H, Hirano N, Sasaki M, Aihara N, Hatsushika S, Tao S, Ohya T, Kajiyama G: Degree of fatty acyl chain unsaturation in biliary lecithin dictates cholesterol nucleation and crystal growth. Biochim Biophys Acta 1215:74-78, 1994
10. Miura H, Tazuma S, Kajiyama G: Partial characterization of regulation biliary lecithin hydrophobicity: association with organic anion-induced solute cholestasis in rats. Biochem J 312:795-797, 1995
11. Hirano N, Tazuma S, Kajiyama G: Transcytotic vesicle fusion with canalicular membranes is modulated by phospholipid species: Implications for biliary lipid secretion. J Gastroenterol Hepatol 12:534-539, 1997
12. Layden TJ, Schwarz J, Boyer JL: Scanning electron microscopy of the rat liver. Gastroenterology 69:724-738, 1975
13. Schrenk D, Gant TW, Preisegger KH, Silverman JA, Marino PA, Thorgeirsson SS: Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates. Hepatology 17:854-860, 1993
14. Naramoto A, Ohno S, Furuta K, Itoh N, Nakazawa K, Nakano M, Shigematsu H: Ultrastructual studies of hepatocyte cytoskeletons of phalloidin-treated rats by quick-freezing and deep-etching method. Hepatology 13:222-229, 1991
15. Harada M, Sakisaka S, Yoshitake M, Shakadoh S, Gondoh K, Noguchi K, Yoshida H, Sata M, Tanikawa K: Ultrastructure of the intracellular membranous system of rat hepatocytes in intrahepatic cholestasis induced by phalloidin. J Hepatol 21:560-566, 1994
16. Loranger A, Barriault C, Yousef IM, Tuchweber B: Structural and functional alterations of hepatocytes during transient phalloidin-induced cholestasis in the rat. Toxicol Appl Pharmacol 137:100-111, 1996
17. Inoue M, Kinne R, Tran T, Biempica L, Arias IM: Rat liver canalicular membrane vesicles: Isolation and topological characterization. J Biol Chem 258:5183-5188, 1983
18. Bolder U, Ton-nu H, Schteingart CD, Frick E, Hofmann AF: Hepatic transport of bile acids and organic anions in endotoxemic rats: Impaired uptake and secretion. Gastroenterology 112:214-225, 1997
19. Keeffe EB, Scharschmidt BF, Blankenship NM, Ockner RK: Studies of relationship among bile flow, liver plasma membrane NaK-ATPase, membrane microviscosity in the rat. J Clin Invest 64:1590-1598, 1979
20. Kwon Y, Lee RD, Morris ME: Hepatic uptake of choline in rat liver basolateral and canalicular membrane vesicle preparations. J Pharmacol Exp Ther 279:774-781, 1996
21. Scharschmidt BF, Keeffe EB, Blankenship NM, Ockner RK: Validation of a recording spectrometric method for measurement of membrane-associated Mg and Na, K-ATPase activity. J Lab Clin Med 93:790-799, 1979
22. Orlowski M, Meister A: γ-Glutamyl-p-nitroanilide: A new convenient substrate for determination and study of L-and D-γ-glutamyl transpeptidase activities. Biochim Biophys Acta 73:679-681, 1963
23. Yamazaki K, Powers SP, LaRusso NF: Biliary proteins: Assessment of quantitative techniques and comparison in gallstone and nongallstone subjects. J Lipid Res 29:1055-1063, 1988
24. Adachi Y, Kobayashi H, Shouji M, Kitano M, Okuyama Y, Yamamoto T: Functional integrity of hepatocyte canalicular membrane transport of taurocholate and bilirubin diglucuronide in Eisai hyperbilirubinemia rats. Life Sci 52:777-784, 1992
25. Bartlet GR: Phosphorus assays in column chromatography. J Biol Chem 234:466-468, 1959
26. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-919, 1959
27. Tazuma S, Hatsushika S, Yamashita G, Aihara N, Sasaki M, Horikawa K, Yamashita Y, Teramen K, Ochi H, Hirano N, Miura H, Ohya T, Hino H, Kajiyama G: Simultaneous micro-analysis of biliary cholesterol, bile acids and fatty acids in lecithin using capillary column gas chromatography: An advantage to assess bile lithogenicity. J Chromatogr Biomed Appl 653:1-7, 1994
28. Miyake H, Tazuma S, Miura H, Yamashita G, Kajiyama G: Partial characterization of mechanisms of cytoprotective action of hydrophilic bile salts against hydrophobic bile salts in rats: relation to canalicular membrane fluidity and packing density. Dig Dis Sci 44:197-202, 1999
29. Papahadjopoulos D, Poste G, Schaeffer BE, Vail WJ: Membrane fusion and molecular segregation in phospholipid vesicles. Biochim Biophys Acta 352:10-28, 1974
30. Papahadjopoulos D, Poste G, Vail WJ: Studies on membrane fusion with natural and model membranes. Methods Membr Biol 10:1-121, 1979
31. Duzgunes N, Ohki S: Calcium-induced interaction of phospholipid vesicles with bilayer lipid membranes. Biochim Biophys Acta 467:301-308, 1977
32. Duzgunes N, Wilschunt J, Papahadjopoulos D: Control of membrane fusion by divalent cations, phospholipid head groups and proteins. In Physical Methods on Biological Membranes and Their Model Systems. F Conti, WE Blumberg, J de Gier, F Pocchiari, (eds). New York, Plenum Press, 1985, pp 193-218
33. Ochi H, Tazuma S, Kajiyama G: Lecithin hydrophobicity modulates the process of cholesterol crystal nucleation and growth in supersaturated model bile systems. Biochem J 318:139-144, 1996
34. Nies AT, Gatmaitan Z, Arias IM: ATP-dependent phosphatidylcholine translocation in rat liver canalicular plasma membrane vesicles. J Lipid Res 37:1125-1136, 1996
35. Ardy van Helvoort, Maria LG, Marion T, van Meer G: Transport of sphingomyelin to the cell surface is inhibited by brefeldin A and in mitosis, where C6-NBD-sphingomyelin is translocated across the plasma membrane by a multidrug transporter activity. J Cell Sci 110:75-83, 1997
36. Bishop WR, Bell RM: Assembly of the endoplasmic reticulum phospholipid bilayer: The phosphatidylcholine transporter. Cell 42:51-60, 1985
37. Higgins CF, Gottesman MM: Is the multidrug transporter a flippase? Trends Biochem Sci 17:18-21, 1992
38. Buschman E, Arceci RJ, Croop JM, Che MX, Arias IM, Housman DE, Gros P: mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J Biol Chem 267:18093-18099, 1992
39. Berr F, Meier PJ, Stieger B: Evidence for the presence of a phosphatidylcholine translocator in isolated rat liver canalicular plasma membrane vesicles. J Biol Chem 268:3976-3979, 1993
40. Ruetz S, Gros P: Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77:1071-1082, 1994
41. Smith AJ, Timmermans-hereijgers JLPM, Roelofsen B, Wirtz KWA, van Blitterswijk WJ, Smit JJM, Schinkel AH, Borst P: The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice. FEBS Lett 354:263-266, 1994
42. Smit JJM, Schinkel AH, Mol CAAM, Majoor D, Mooi WJ, Jongsma APM, Lincke CR, Borst P: Tissue distribution of the human MDR3 P-glycoprotein. Lab Invest 71:638-649, 1994
43. Ruetz S, Gros P: Enhancement of Mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate: Implications for hepatic bile formation. J Biol Chem 270:25388-25395, 1995
44. Kullack-Ublick GA, Gerloff T, Hagenbuch B, Berr F, Meier PJ, Stieger B: Expression of a rat liver phosphatidylcholine translocator in Xenopus laevis oocytes. Hepatology 23:1254-1259, 1996