The generation of monoclonal antibodies in mice: Influence of adjuvants on the immune response, fusion efficiency and distress

Laboratory Animals

Volumn 33, Issue 4, 1999, Pages 334-350

  Ferber, P C ^a   Ossent, P ^b   Homberger, F R ^c   Fischer, R W ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adjuvants; Distress; MAB generation in mice

Indexed keywords

ANTIGEN; FREUND ADJUVANT; GERBU; IMMUNOLOGICAL ADJUVANT; MONOCLONAL ANTIBODY; PAM 3; PC3 SK4; POLYADENYLIC POLYURIDYLIC ACID; POLYCLONAL ANTIBODY; RAS; RIBI ADJUVANT; SPECAL; TITERMAX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DISTRESS SYNDROME; FEMALE; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNIZATION; MOUSE; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0032829241     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/002367799780487896     Document Type: Article

References (35)

1. Askonas BA, Humphrey JH (1958) Formation of specific antibodies and t-globulin in vitro. A study of the synthetic ability of various tissues from rabbits immunized by different methods. Biochemical Journal 68, 252-61
2. Bessler WG, Baier W, v.d. Esche U, et al. (1997) Bacterial lipopeptides constitute efficient novel immunogens and adjuvants in parenteral and oral immunization. Behring Institute Mitteilungen 390-9
3. Bessler WG, Jung G (1992) Synthetic lipopeptides as novel adjuvants. Research in Immunology 143, 548-53; discussion 579-80
4. Boersma WJ, Bogaerts WJ, Bianchi AT, Claassen E (1992) Adjuvant properties of stable water-in-oil emulsions: evaluation of the experience with Specol. Research in Immunology 143, 503-12
5. Bulthuis RJA, Bergman AF, Nijessen S, et al. (1997) Automated behaviour classification: the LABORAS project. In: Harmonization of Laboratory Animal Husbandry. Proceedings of the 6th FELASA Symposium (O'Donoghue PN, ed). London: Royal Society of Medicine Press, pp 17-18
6. Carmona-Ribeiro AM, Chaimovich H (1986) Salt-induced aggregation and fusion of dioctadecyldimethylammonium chloride and sodium dihexadecylphosphate vesicles. Biophysical Journal 50, 621-8
7. Ellouz F, Adam A, Ciorbaru R, Lederer E (1974) Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochemical Biophysical Research Communications 59, 1317-25
8. Galfre G, Howe SC, Milstein C, Butcher GW, Howard JC (1977) Antibodies to major histocompatibility antigens produced by hybrid cell lines. Nature 266, 550-2
9. Grubhofer N (1995) An adjuvant formulation based on N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with dimethyldioctadecylammonium chloride and zinc-L-proline complex as synergists. Immunology Letters 44, 19-24
10. Harlow E, Lane D (1988) Antibodies: a Laboratory Manual. New York: Cold Spring Harbor Laboratory
11. Hilgers LA, Snippe H (1992) DDA as an immunological adjuvant. Research in Immunology 143, 494-503; discussion 574-6
12. Hovanessian AG, Galabru J, Riviere Y, Montagnier L (1988) Efficiency of poly(A).poly(U) as an adjuvant [letter]. Immunology Today 9, 161-2
13. Hovanessian AG, Riviere Y, Montagnier L, Michelson M, Lacour J, Lacour F (1982) Enhancement of interferon-mediated protein kinase in mouse and human plasma in response to treatment with polyadenylic-polyuridylic acid (poly A:poly U). Journal of Interferon Research 2, 209-15
14. Hu JG, Ide A, Yokoyama T, Kitagawa T (1989a) Studies on the optimal immunization schedule of the mouse as an experimental animal. The effect of antigen dose and adjuvant type. Chemical Pharmaceutical Bulletin (Tokyo) 37, 3042-6
15. Hu JG, Kitagawa T (1990) Studies on the optimal immunization schedule of experimental animals. VI. Antigen dose-response of aluminum hydroxide-aided immunization and booster effect under low antigen dose. Chemical Pharmaceutical Bulletin (Tokyo) 38, 2775-9
16. Hu JG, Tanimori H, Shihata M, Yokoyama T, Kitagawa T (1989b) Comparative study of complete and incomplete Freund's adjuvants for immunization of a drug immunogen using enzyme immunoassay methods. Chemical Pharmaceutical Bulletin (Tokyo) 37, 1316-20
17. Hu JG, Yokoyama T, Kitagawa T (1990a) Studies on the optimal immunization schedule of experimental animals. IV. The optimal age and sex of mice, and the influence of booster injections. Chemical Pharmaceutical Bulletin (Tokyo) 38, 448-51
18. Hu JG, Yokoyama T, Kitagawa T (1990b) Studies on the optimal immunization schedule of experimental animals. V. The effects of the route of injection, the content of mycobacteria in Freund's adjuvant and the emulsifying antigen. Chemical Pharmaceutical Bulletin (Tokyo) 38, 1961-5
19. Johnson AG (1979) Modulation of the immune system by synthetic polynucleotids. In: Springer Seminars in Immunopathology. New York: Springer Verlag, pp 149-68
20. Kraft V, Deeny AA, Blanchet HM, et al. (1994) Recommendations for the health monitoring of mouse, rat, hamster, guineapig and rabbit breeding colonies. Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Animal Health accepted by the FELASA Board of Management November 1992. Laboratory Animals 28, 1-12
21. Kenney JS, Hughes BW, Masada MP, Allison AC (1989) Influence of adjuvants on the quantity, affinity, isotype and epitope specificity of murine antibodies. Journal of Immunological Methods 121, 157-66
22. Kuijpers M, Walvoort H (1991) Discomfort and distress in rodents during chronic studies. In: Animals in Biomedical Research. Replacement, Reduction and Refinement. Present Possibilities and Future Prospects (Hendriksen CFM, Köeter HBWM, eds). Amsterdam: Elsevier Science Publishers, pp 247-63
23. Lacour F (1985) Polyadenylic-polyuridylic acid: biological response-modifying activities in mice: In vivo organ distribution and pharmacokinetics in rabbits. Journal of Biological Response Modifiers 4, 490-4
24. Leenaars PP, Hendriksen CF, Koedam MA, Claassen I, Claassen E (1995) Comparison of adjuvants for immune potentiating properties and side effects in mice. Veterinary Immunology and Immunopathology 48, 123-38
25. Leenaars PP, Koedam MA, Wester PW, Baumans V, Claassen E, Hendriksen CF (1998) Assessment of side effects induced by injection of different adjuvant/antigen combinations in rabbits and mice. Laboratory Animals 32, 387-406
26. Marin JG, Rodrigue F, Mencia-Huerta JM, Chabrier PE, Braquet P (1993) Activation of the murine monocyte/macrophage cell line, J774A1 by poly(A).poly(U): I. Binding of poly(A).poly(U) and induction of oligo-2′,5′-adenylate synthetase. Biochimica et Biophysica Acta 1178, 103-10
27. Nagao S, Tanaka A (1980) Muramyl dipeptide-induced adjuvant arthritis. Infection and Immunology 28, 624-6
28. Odean MJ, Trachte GJ, Johnson AG (1991) Characterization of immune suppression induced by polyribonucleotides. International Journal of Immunopharmacology 13, 339-48
29. Peters JH, Baumgarten H (1990) Monoklonale Antikörper, Herstellung und Characterisierung. Berlin: Springer-Verlag
30. Waters RV, Terrell TG, Jones GH (1986) Uveitis induction in the rabbit by muramyl dipeptides. Infection and Immunology 51, 816-25
31. Wiedemann F, Link R, Pumpe K, et al. (1991) Histopathological studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates. Journal of Pathology 164, 265-71
32. Won SJ, Lin MT (1991) Pyrogenicity of polyadenylic.polyuridylic acid in rabbits. Naunyn Schmiedeberg's Archives of Pharmacology 343, 551-7
33. Wright EM, Woodson JF (1990) Clinical assessment of pain in laboratory animals. In: The Experimental Animal in Biomedical Research (Rollin BE, Kesel ML, eds). Boca Raton, Florida: CRC Press, pp 206-15
34. Youn JK, Hovanessian AG, Riviere Y, Hue G, Lacour F (1983) Enhancement of natural killer cell activity and 2-5A synthetase in mice treated with polyadenylic.polyuridylic acid. Cellular Immunology 79, 298-308
35. Zimmermann DR, Dours-Zimmermann MT, Schubert M, Bruckner-Tudcrman L (1994) Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the dermis. Journal of Cell Biology 124, 817-25