Detection of methadone, LAAM, and their metabolites by methadone immunoassays

Journal of Analytical Toxicology

Volumn 23, Issue 6, 1999, Pages 500-505

  Cheever, Matthew L ^a,b   Armendariz, Gerardo A ^a,c   Moody, David E ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVACETYLMETHADOL; METHADONE; PYRROLIDINE DERIVATIVE;

ARTICLE; CROSS REACTION; DEMETHYLATION; DRUG DETERMINATION; DRUG STRUCTURE; DRUG URINE LEVEL; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; RADIOIMMUNOASSAY; URINALYSIS;

EID: 0032826801     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/23.6.500     Document Type: Article

References (24)

1. V.P. Dole. Implications of methadone maintenance for therapies of narcotic addiction. The Albert Lasker Awards. J. Am. Med. Assoc. 260: 3025-3029 (1988).
2. M. Farrell, J. Ward, R. Mattrick, W. Hall, G.V. Stimson, D. da Jarlais, M. Gossop, and J. Strang. Methadone maintenance treatment in opiate dependence: a review. Br. Med. J. 309: 997-1001 (1994).
3. D.E. Moody, M.E. Alburges, R.J. Parker, J.M. Collins, and J.M. Strong. The involvement of cytochrome P450 3A in the N-demethylation of l-α-acetylmethadol (LAAM), norLAAM and methadone. Drug Metab. Dispos. 25: 1347-1353 (1997).
4. H.R. Sullivan, and S.L. Due. Urinary metabolites of d,l-methadone in maintenance subjects. J. Med. Chem. 16: 909-913 (1973).
5. J.H. Jaffe, E.C. Senay, C.R. Schuster, P.R. Renault, B. Smith, and S. DiMenza. Methadyl acetate vs methadone: a double-blind study in heroin users. J. Am. Med. Assoc. 222: 437-442 (1972).
6. R. Levine, A. Zaks, M. Fink, and M. Freedman. Levomethadyl acetate. Prolonged duration of opioid effects, including cross tolerance to heroin, in man. J. Am. Med. Assoc. 226: 316-318 (1973).
7. W. Ling, C. Charuvastra, S.C. Kaim, and J. Klett. Methadyl acetate and methadone as maintenance treatments for heroin addicts. Arch. Gen. Psychiatry 33: 709-720 (1976).
8. A. Pohland, F.J. Marshall, and T.P. Carney. Optically active compounds related to methadon. J. Am. Chem. Soc. 71: 460-462 (1949).
9. J.S. Horng, S.E. Smits, and D.T. Wong. The binding of optical isomers of methadone, α-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain. Res. Commun. Chem. Pathol. Pharmacol. 14: 621-629 (1976).
10. S.A. Walczak, M.H. Makman, and E.L. Gardner. Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala. Eur. J. Pharmacol. 72: 343-349 (1981).
11. LAAM - a long-acting methadone for treatment of heroin addiction. The Medical Letter 36: 52 (1994).
12. R.F. Kaiko, N. Chatterjie, and C.E. Inturrisi. Simultaneous determination of acetylmethadol and its active biotransformation products in human biofluids. J. Chromatogr. 109: 247-258 (1975).
13. A.J. Saxon, D.A. Calsyn, V.M. Haver, and L. Erickson. A nationwide survey of urinalysis practices of methadone maintenance clinics. Arch. Pathol. Lab. Med. 114: 94-100 (1990).
14. P.J. Fudala, E. Yu, and K. Kampman. An assessment of the potential cross-reactivity of levo-alpha-acetylmethadol (LAAM) with urine assays for methadone. J. Mainten. Addict. 1: 93-101 (1997).
15. Behring Diagnostics. Emit® d.a.u.™ Methadone Assay package insert. (October 1996).
16. Diagnostic Reagents. Methadone Enzyme lmmunoassay package insert. (March 1997).
17. Diagnostix. Single Step™ Pharmadiagnostic Methadone ELISA Test Kit package insert. (January 1997).
18. STC Technologies. Methadone Micro-Plate EIA package insert. (December 1996).
19. Abbott Laboratories. TDx®/TDxFLx® Methadone package insert. (May 1996).
20. Roche Diagnostic Systems. Abuscreen Online for Methadone package insert. (March 1996).
21. Diagnostic Products Corporation. Coat-A-Count® Methadone in Urine package insert. (March 1992).
22. Microgenics Corporation. CEDIA® DAU EDDP-Qualitative package insert. (in preparation).
23. D.M. Chinn, B.S. Finkle, D.J. Crouch, and T.A. Jennison. The biodisposition of l-α-acetylmethadol and its principal metabolites: some fatal and nonfatal cases. J. Anal. Toxicol. 3: 143-149 (1979).
24. D.E. Moody, D.J. Crouch, C.O. Sakashita, M.E. Alburges, K. Minear, J.E. Schulties, and R.L. Foltz. A gas chromatographic-positive ion chemical ionization-mass spectrometric method for determination of l-α-acetylmethadol (LAAM), norLAAM, and dinorLAAM in plasma, urine, and tissue. J. Anal. Toxicol. 19: 343-351 (1995).