Effects of prokinetic agents on contractile responses to electrical field stimulation of isolated guinea pig trachea

Journal of the Formosan Medical Association

Volumn 98, Issue 8, 1999, Pages 567-572

  Yau, Kuo Inn ^a,d   Ko, Feng Nien ^b,e   Chien, Chih Hao ^c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c Provincial Hsin Chu Hospital   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e R and D Division   (Taiwan)

Author keywords

Cisapride; Electrical field stimulation; Guinea pig; Metoclopramide; Prokinetic agent; Trachea

Indexed keywords

CISAPRIDE; METOCLOPRAMIDE; PROKINETIC AGENT;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTROSTIMULATION; GUINEA PIG; LUNG FUNCTION; MALE; MUSCLE CONTRACTILITY; NONHUMAN; TRACHEA;

ANIMALS; CISAPRIDE; ELECTRIC STIMULATION; GUINEA PIGS; MALE; METOCLOPRAMIDE; MUSCLE CONTRACTION; TRACHEA;

EID: 0032826730     PISSN: 09296646     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Herbst JJ: Gastroesophageal reflux. J Pediatr 1981;98: 859-70.
2. Fiascone JM, Thodes TT, Grandgeorge SR, et al: Bronchopulmonary dysplasia: a review for the pediatrician. Curr Probl Pediatr 1989;19:169-227.
3. Michiels M, Monbaliu J, Hendriks R, et al: Pharmacokinetics and tissue distribution of the new gastrokinetic agent cisapride in rat, rabbit and dog. Arzneim-Forsch/ Drug Res 1987;37:1159-67.
4. Harrington RA, Hamilton CW, Brogden RN, et al:Metoclopramide. An updated review of its pharmacological properties and clinical use. Drugs 1983;25:451-94.
5. McCallum RW, Prakas C, Campoli-Richards DM, et al: Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders. Drugs 1988;36:652-81.
6. Wiseman LR, Faulds D: Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders. Drugs 1994; 47:116-52.
7. Takahashi T, Ward KJ, Tadjkarimi S, et al: 5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. Am J Respir Crit Care Med 1995;152:377-80.
8. Clerici C, Macquin-Mavier I, Harf A: Nonadrenergic bronchodilation in adult and young guinea pigs. J Appl Physiol 1989;67:1764-9.
9. Grundström N, Andersson RGG, Wikberg JES: Pharmacological characterization of the autonomous innervation of the guinea pig tracheobronchial smooth muscle. Ada Pharmacol et Toxicol 1981;49:150-7.
10. Ellis JL, Undem BJ: Non-adrenergic, non-cholinergic contractions in the electrically field stimulated guinea pig trachea. Br J Pharmacol 1990;101:875-80.
11. 2 receptor activation on acetylcholine release. Br J Pharmacol 1991;102:1003-7.
12. 2 receptor: use of 5-methyltryptamine and dipropyl-5-carbosamidotryptamine. J Pharmacol Exp Ther 1993;264:271-5.
13. Lucchelli A, Santagostino-Barbone MG, Barbieri A, et al: A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea pig isolated trachea. Br J Pharmacol 1994;112:763-8.
14. 2 receptors augment cholinergic nerve-mediated contraction of rat bronchi. Eur J Pharmacol 1993;231:339-46.
15. 3 receptors augment neuronal, cholinergic contractions in guinea pig trachea. Eur J Pharmacol 1993;234:109-12.
16. Baumgartner RA, Wills-Karp M, Kaufman MJ, et al: Serotonin induces constriction and relaxation of the guinea pig airway. J Pharmacol Exp Ther 1990;255:165-73.
17. Kebabian JW, Calne DB: Multiple receptors for dopamine. Nature 1979;227:93-6.
18. 4 receptors. Eur J Pharmacol 1991;205: 203-8.
19. Linnik MD, Butler BT, Gaddis RR, et al: Analysis of serotonergic mechanisms underlying benzamide-induced gastroprokinesis. J Pharmacol Exp Ther 1991; 259:501-7.
20. 4 receptors. J Pharm Pharmacol 1997;49:58-65.
21. Schuurkes JAJ, Helsen LFM, Ghoos E: Stimulation of gastroduodenal motor activity: dopaminergic and cholinergic modulation. Drug Dev Res 1985;8:233-41.
22. Buchheit KH, Costall B, Engel G, et al: 5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205-930 in the guinea pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in-vivo. J Pharm Pharmacol 1985;37:664-7.
23. Ward JK, Fox AJ, Barnes PJ, et al: Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea pig airways in vitro by activation of an atypical 5-HT receptor. Br J Pharmacol 1994;111:1095-102.
24. Lundberg JM, Saria A, Brodin E, et al: A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig. Pror Natl Acad Sci USA 1983;80:1120-4.