Effect of delivery system on the pharmacokinetic and phototherapeutic properties of bis(methyloxyethyleneoxy) silicon-phthalocyanine in tumor-bearing mice

Journal of Photochemistry and Photobiology B: Biology

Volumn 50, Issue 2-3, 1999, Pages 124-128

  Wohrle D ^a   Muller, S ^a   Shopova, M ^b   Mantareva, V ^b   Spassova, G ^b   Vietri, F ^c   Ricchelli, F ^d   Jori, G ^d  

^a UNIVERSITY OF BREMEN   (Germany)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

Axial ligands; Cremophor EL; Liposomes; Pharmacokinetics; Photodynamic therapy; Si(IV) phthalocyanine; Tumor model

Indexed keywords

CREMOPHOR; LIPOSOME; PHTHALOCYANINE DERIVATIVE; SILICON DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ACCUMULATION; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG LIVER LEVEL; DRUG SYNTHESIS; DRUG TUMOR LEVEL; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LEWIS CARCINOMA; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SKIN;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ANIMALS; BRAIN; EMULSIONS; FEMALE; INDOLES; LIPOSOMES; LUNG; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; ORGANOSILICON COMPOUNDS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLYETHYLENE GLYCOLS; SKIN; TISSUE DISTRIBUTION; VEHICLES;

EID: 0032826515     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(99)00082-2     Document Type: Article

References (16)

1. [1] T.J. Dougherty, Photosensitizers: therapy and detection of malignant tumours, Photochem. Photobiol. 45 (1987) 879-883.
2. [2] H.I. Pass, Photodynamic therapy in oncology: mechanism and clinical use, J. Natl. Cancer Inst. 85 (1993) 443-456.
3. [3] T.J. Dougherty, C.J. Gomer, B.W. Anderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, Q. Peng, Photodynamic therapy, J. Natl. Cancer Inst. 90 (1998) 889-905.
4. [4] B. Rihter, M.E. Kenney, W.E. Ford, M.A.J. Rodgers, Synthesis and photoproperties of diamagnetic octabutoxyphthalocyanines with deep-red absorbance, J. Am. Chem. Soc. 95 (1991) 598-603.
5. [5] N.L. Oleinick, A.R. Antunez, M.E. Clay, B.D. Rihter, M.E. Kenney, New phthalocyanine photosensitizer for photodynamic therapy, Photochem. Photobiol. 57 (1993) 242-247.
6. [6] D. Wöhrle, A. Ardeschirpur, S. Müller, A. Henerman, G. Graschew, P. Schlag, Various reactive natural porphyrin based sensitizers for potential application in PDT, in: P. Spinelli, M. Dal Fante, R. Marchesini (Eds.), Photodynamic Therapy and Biomedical Lasers, Excerpta Medica, Amsterdam, 1992, pp. 774-779.
7. [7] M. Soncin, L. Polo, E. Reddi, G. Jori, M.E. Kenney, S. Chang, M. Rodgers, Effect of axial ligation and delivery system on the tumor-localizing and photosensitizing properties of Ge (IV)-octabutoxyphthalocyanines, Br. J. Cancer 71 (1995) 727-732.
8. [8] V. Cuomo, G. Jori, B. Rihter, M.E. Kenney, M. Rodgers, Liposome-delivered Si(IV)-naphthalocyanine as a photodynamic sensitizer for experimental tumors: pharmacokinetic and phototherapeutic studies, Br. J. Cancer 62 (1990) 966-970.
9. [9] D. Wöhrle, M. Shopova, S. Müller, A. Milev, V. Mantareva, K. Krastev, Liposome-delivered Zn(II) -2,3 naphthalocyanines as potential sensitizers for PDT: synthesis, photochemical, pharmacokinetic and phototherapeutic studies, J. Photochem. Photobiol. B: Biol. 21 (1993) 307-309.
10. [10] I. Freitas, Lipid accumulation: the common feature to photosensitizer-retaining normal and malignant tissues, J. Photochem. Photobiol. B: Biol. 7 (1990) 359-361.
11. [11] N. Michailov, M. Peeva, I. Angelov, D. Wöhrle, S. Müller, G. Jori, F. Ricchelli, M. Shopova, Fluence rate effects on photodynamic therapy of B 16 pigmented melanoma, J. Photochem. Photobiol. B: Biol. 37 (1997) 154-157.
12. [12] G. Jori, Tumour photosensitizers: approaches to enhance the selectivity and efficiency of photodynamic therapy, J. Photochem. Photobiol. B: Biol. 36 (1996) 87-93.
13. [13] C.V. Schonermark, A. Volkmer, S. Müller, D. Wöhrle, B. Roder, Spectroscopic studies on Si-phthalocyanines and Si-naphthalocyanines, BiOS '94, Lille, France, Sept. 1-6, 1994, SPIE Proc., vol. 2325, 1994, p. 339.
14. [14] M. Soncin, L. Polo, E. Reddi, G. Jori, M.E. Kenney, G. Cheng, M.A.J. Rodgers, Effect of the delivery system on the biodistribution of Ge(IV) octabutoxy-phthalocyanines in tumor-bearing mice, Cancer Lett. 89 (1995) 101-106.
15. [15] G. Jori, Low density lipoproteins-liposome delivery systems for tumour photosensitizers in vivo, in: B.W. Henderson, T.J. Dougherty (Eds.), Photodynamic Therapy. Basic Principles and Clinical Applications, Marcel Dekker, New York, 1992, pp. 173-186.
16. [16] J.L. Goldstein, R.G.W. Anderson, N.S. Brown, Coated pits, coated vesicles and receptor-mediated endocytosis, Nature 279 (1979) 679-685.