HLA-DR polymorphism influences T-cell precursor frequencies to Epstein-Barr virus (EBV) gp110: Implications for the association of HLA-DR antigens with rheumatoid arthritis

Tissue Antigens

Volumn 54, Issue 2, 1999, Pages 146-152

  Toussirot, E ^a   Auger, I ^d   Roudier, C ^d   Luka, J ^c   Wendling, D ^a   Tiberghlen, P ^b   Roudier, Jean ^d  

^a UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

^b Etablissement de Transfus Sang   (France)

^c EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^d INSERM   (France)

Author keywords

EBV gp110; HLA DRB1; Rheumatoid arthritis; T cell

Indexed keywords

HLA DR ANTIGEN; VIRUS GLYCOPROTEIN;

ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; HAPLOTYPE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; VIRUS REPLICATION;

DNA VIRUSES; HUMAN HERPESVIRUS 4;

EID: 0032825886     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.1999.540205.x     Document Type: Article

References (17)

1. Gregersen P, Silver J, Winchester R. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to Rheumatoid Arthritis. Arthritis Rheum 1987: 30: 1205-13.
2. Tosato G, Steinberg A, Yarchoan R et al. Abnormally elevated frequency of Epstein-Barr virus infected B cells in the blood of patients with rheumatoid arthritis. J Clin Invest 1984: 73: 1789-95.
3. Newkirk M, Watanabe Duffy K, Leclerc J, Lambert N, Shiroky J. Detection of Cytomegalovirus, Epstein-Barr virus and Herpes virus-6 in patients with rheumatoid arthritis with or without Sjogren's syndrome. Br J Rheumatol 1994: 33: 317-20.
4. Luka J, Chase R, Pearson G. A sensitive enzyme linked immunosorbent assay against the major EBV associated antigens. I. Correlation between ELISA and immunofluorescence using purified antigens. J Immunol Method 1984: 67: 145-56.
5. Gong M, Ooka T, Matsuo T, Kieff E. Epstein-Barr virus protein homologous to Herpes Simplex virus gB. J Virol 1987: 61: 499-508.
6. Gong M, Kieff E. Intracellular trafficking of two major Epstein-Barr virus glycoproteins, gp350/220 and gp110. J Virol 1990: 64: 1507-16.
7. Roudier J, Petersen J, Rhodes G, Luka J, Carson D. Susceptibility to rheumatod arthritis maps to a T cell epitope shared by the HLA-Dw4 DRβ1 chain and the Epstein-Barr virus glycoprotein gp110. Proc Natl Acad Sci U S A 1989: 86: 5104-8.
8. Kishishita M, Luka J, Vroman B, Pearson G. Production of monoclonal antibody to a late intracellular Epstein-Barr virus induced antigen. Virology 1989: 133: 363-75.
9. Geburher L, Tiercy JM, Freidel C et al. Apparent HLA-DR triplet due to the coexpression of a DRB5 encoded molecule on a DR1 haplotype. Hum Immunol 1992: 34: 91-8.
10. Limiting dilution analysis of human T cells in peripheral blood. Pinnacles 1993: 3: 10-1.
11. Glantz S. The special case of two groups: the T test. In: Glantz S, ed. Primer of Biostatistics. 3rd edn. New York: McGraw Hill Inc, 1992: 67-109.
12. Curtsinger J, Liu Y, Radecke R et al. Molecular analysis of the immune response to human cytomegalovirus glycoprotein B. Low gB specific T and B cell responses are associated with expression of certain HLA-DR alleles. J Gen Virology 1994: 75: 301-7.
13. Benazet JF, Reviron D, Mercier P, Roux H, Roudier J. HLA-DRB1 alleles associated with rheumatoid arthritis in Southern France. Absence of extraarticular disease despite expression of the shared epitope. J Rheumatol 1995: 22: 607-10.
14. Angelini G, Morozzi G, Delfino L et al. Analysis of HLA-DP, DQ and DR alleles in adult Italian rheumatoid arthritis patients. Hum Immunol 1992: 34: 135-41.
15. Perdriger A, Guggenbuhl P, Chales G et al. The role of HLA-DR-DR and HLA-DR-DP interactions in genetic susceptibility to rheumatoid arthritis. Hum Immunol 1996: 46: 42-8.
16. Yelamos J, Garcia Lozano J, Moreno I et al. Association of HLA-DR4-Dw15 and DR10 with rheumatoid arthritis in a Spanish population. Arthritis Rheum 1993: 36: 811-4.
17. Auger I, Escola JM, Gorvel JP, Roudier J. HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70 kD heat shock proteins. Nat Med 1996: 2: 306-10.