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1
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0033602054
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A multistate foodborne outbreak of hepatitis A
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Hutin YJF, Poof V, Cramer EH, Nainan OV, Weth J, Williams IT, et al.: A multistate foodborne outbreak of hepatitis A. N Engl J Med 1999, 340:595-602. A large outbreak of hepatitis A occurred in Michigan with sporadic cases occurring in neighbor states. Using genetic sequencing, the authors demonstrated that both hepatitis A cases from the outbreak and hepatitis A cases in other slates had identical viral RNA sequences, thereby linking the Michigan outbreak with those in the other states. This hepatitis A outbreak was associated with consumption of frozen strawberries from the same processor, served in schools. The strawberries had been contaminated before freezing, possibly during harvest.
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N Engl J Med
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3
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0031915859
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Safety and immunogenicity of hepatitis A vaccine in patients with chronic liver disease
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Keeffe EB, Iwarson S, McMahon BJ, Lindsay KL, Koff RS, Manns M, et al.: Safety and immunogenicity of hepatitis A vaccine in patients with chronic liver disease. Hepatology 1998, 27:881-886.
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The diverse patterns of hepatitis A epidemiology in the United States-implications for vaccination strategios
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Bell BP, Shapiro CN, Alter MJ, Moyer LA, Judson FN, Mottram K, et al.; The diverse patterns of hepatitis A epidemiology in the United States-implications for vaccination strategios. J Infect Dis 1998, 178:1579-1584.
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6
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Sagliocca L, Amoroso P, Stroffolini T, Adamo B, Tosti ME, Lettieri G, et al.: Efficacy of hepatitis A vaccine in prevention of secondary hepatitis A infection: a randomised trial. Lancet 1999, 353:1136-1139. This is a randomized, controlled trial of hepatitis A vaccine in 146 households in which sporadic hepatitis A cases occurred. Secondary cases occurred in 2.8% of households in which household members were vaccinated, group, versus 13.3% of households in which household members were not unvaccinated. One secondary infection was prevented for every 18 individuals vaccinated.
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7
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Zimmerman RK, Mieczkowski TA: How important is early childhood hepatitis B vaccination? a survey of primary care physicians, J Fam Pract 1998, 47:370-374.
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Mutimer D, Pillay D, Dragon E, Tang H, Ahmed M, O'Donnell K, et al.; High pre-treatment serum hepatitis B virus titre predicts failure of lamivudine prophylaxis and graft re-infection after liver transplantation. J Hepatol 1999, 30:715-721.
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9
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Chang MH, Chen CJ, Lai MS, Hsu HM, Wu TC, Kong MS, et al.: Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. N Engl J Med 1997, 336:1855-1859.
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10
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11
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0031666164
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Tang JR, Hsu H, Lin H, Ni YH, Chang M: Hepatitis B surface antigenemia at birth: a long term follow up study. J Pediatr 1998, 133:374-377.
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12
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0031716163
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Incidence of hepatitis B virus infection in the United States, 1976-1994: Estimates from the National Health and Nutrition Examination Surveys
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Coleman PJ, McQuillan GM, Moyer LA, Lambert SB, Margolis HS: Incidence of hepatitis B virus infection in the United States, 1976-1994: estimates from the National Health and Nutrition Examination Surveys. J Infect Dis 1998, 178:954-959.
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13
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El-Serag H, Mason AC; Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999, 340:745-750.
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14
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The increasing incidence of hepatocellutar carcinoma
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Ince N, Wands JR: The increasing incidence of hepatocellutar carcinoma. N Engl J Med 1999, 340:798-799. Using surveillance data analysis, these authors show a progression of the incidence of hepatocellular carcinoma in the United States from 1.4 cases per 100,000 people (1976-1980) to 2.4 cases per 100,000 people (1991-1995), with a shift toward infection in younger people. Hepatitis B and C are the putative risk factors. This rising incidence could be related to the cohort of people infected by hepatitis B and C virus during the true needle sharing, intravenous drug use, and contaminated blood products of the 1960s and 1970s.
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N Engl J Med
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Ince, N.1
Wands, J.R.2
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15
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0032102924
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Ikeda K, Saitoh S, Suzuki Y, Kobayashi M, Tsubota A, Koida I, et al.: Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients. J Hepatol 1998, 28:930-938. This is a prospective evaluation of 2215 patients with viral hepatitis. The median observation period was 4.1 years. Chronic hepatitis B developed to cirrhosis in 10.2% of 610 adult patients. The cumulative progression rate to cirrhosis reached 21% after 10 years and 37% after 15 years, whereas the amount of alcohol intake was shown to be an independent factor of progression to cirrhosis.
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J Hepatol
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Ikeda, K.1
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16
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Wong JB: Interferon treatment for chronic hepatitis B: costs and effectiveness. Acta Gastroenterol Belg 1998, 61:238-242.
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Wong, J.B.1
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17
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Outcome of chronic hepatitis B in Caucasian children during a 20-year observation period
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Bortolotti F, Jara P, Crivellaro C, Hierro L, Cadrobbi P, Frauca E, et al.: Outcome of chronic hepatitis B in Caucasian children during a 20-year observation period. J Hepatol 1998, 29:184-190. Mediterranean children were followed for an average of 13 years, some of them treated. The majority of these children had postnatal contamination. Of these, 84% cleared HBs ag on follow-up but only 6% lost HBs ag. Hepatitis relapse was observed after HBe ag loss in nine patients, some of them being infected with HBe minus precore mutants. Two patients developed hepatocellular carcinoma.
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(1998)
J Hepatol
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Bortolotti, F.1
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18
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84984541485
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Precore stop codon mutant in chronic hepatitis B virus infection in children: Its relation to hepatitis Be seroconversion and maternal hepatitis B surface antigen
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Chang MH, Hsu HY, Ni YH, Tsai KS, Lee PJ, Chen PJ, et al.: Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis Be seroconversion and maternal hepatitis B surface antigen. J Hepatol 1998, 28:915-922.
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J Hepatol
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Chang, M.H.1
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Omata M: Treatment of chronic hepatitis B infection. N Engl J Med 1998, 339:114-115.
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20
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Sokal EM, Conjeevaram H, Roberts E, Alvarez F, Bern E, Goyens P, et al: Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial. Gastroenterology 1998, 114:988-995. The largest ever published, randomized, controlled trial of interferon for the treatment of chronic hepatitis B in children. Interferon, given at a dosage of 6 MU 3 times per week for 6 months, was able to promote HBe ag and HBs ag loss in 28% of treated patients versus 11% of untreated patients at 1 year. At 18 months, 33% of treated patients had lost HBe ag. This was accompanied by normalization of transaminases and improvement of histology. HBs ag loss was achieved in 10% of treated children versus 1% of untreated children.
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Gastroenterology
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Sokal, E.M.1
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21
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A one year trial of lamivudine for chronic hepatitis B
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Lai CL, Chine RN, Leung NWY, Chang IT, Guan R, Tai DI, et al.: A one year trial of lamivudine for chronic hepatitis B. N Engl J Med 1998, 339:61-68.
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22
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Therapy for chronic hepatitis B: Nucleoside analogues in adult and pediatric patients
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Conjeevaram HS: Therapy for chronic hepatitis B: nucleoside analogues in adult and pediatric patients. Acta Gastroenterol Belg 1998, 61:224-227.
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Conjeevaram, H.S.1
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23
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0001666675
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Dose-finding and safety of lamivudine (LAM) in children and adolescents with chronic hepatitis B [abstract]
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Sokal EM, Roberts EA, Mieli-Vergani G, McPhillips P, Johnson P, Boxall E, Kelly D: Dose-finding and safety of lamivudine (LAM) in children and adolescents with chronic hepatitis B [abstract]. Hepatology 1998, 28(suppl):1306.
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Hepatology
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Sokal, E.M.1
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Johnson, P.5
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24
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Prevalence and manifestations of hepatitis C seropositivity in children in an endemic area
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Lu SN, Chen HC, Tang CM, Wu MH, Yu ML, Lu CF, et al.: Prevalence and manifestations of hepatitis C seropositivity in children in an endemic area. Pediatr Infect Dis 1998, 17:142-145.
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Lu, S.N.1
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25
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Mother to child transmission of hepatitis C virus: Prospective study of risk factors and timing of infection in children born to women seronegative for HIV-1
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Resti M, Azzari C, Mannelli F, Moriondo M, Novembre E, de Martino M, Vierucci A: Mother to child transmission of hepatitis C virus: prospective study of risk factors and timing of infection in children born to women seronegative for HIV-1; BMJ 1998, 317:437-440. This study includes a large number of mother-infant pairs, which allows statistical analysis of variables associated with transmission (with the exclusion of HIV coinfection).
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BMJ
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Resti, M.1
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26
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Role of breast-feeding in transmission of hepatitis C virus to infants of HIV-infected mothers
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Kumar RM, Shahul S: Role of breast-feeding in transmission of hepatitis C virus to infants of HIV-infected mothers. J Hepatol 1998, 29:191-197.
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J Hepatol
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Kumar, R.M.1
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27
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HCV-RNA levels increase during pregnancy in women with chronic hepatitis C
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Wejstal R, Widell A, Norkrans G: HCV-RNA levels increase during pregnancy in women with chronic hepatitis C. Scand J Infect Dis 1998, 30:111-113. These authors show that HCV RNA levels increase at the end of pregnancy, thus possibly favoring transmission.
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Scand J Infect Dis
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28
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Prospective study of mother-to-infant transmission of hepatitis C virus (HCV) infection
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Mazza C, Ravaggi A, Rodella A, Padula D, Muse M, Lomini M, et al., for the Study Group of Vertical Transmission: Prospective study of mother-to-infant transmission of hepatitis C virus (HCV) infection. J Med Virol 1998, 54:12-19.
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J Med Virol
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Mazza, C.1
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29
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0006879897
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Increased transmission of vertical hepatitis C virus (HCV) infection to human immunodeficiency virus (HIV)-infected infants of HIV- and HCV-coinfected women
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Papaevangelou V, Pollack H, Rochford G, Kokka R, Hou Z, Chernoff D, et al.; Increased transmission of vertical hepatitis C virus (HCV) infection to human immunodeficiency virus (HIV)-infected infants of HIV- and HCV-coinfected women. J infect Dis 1998, 178:104-152.
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30
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Bortolotti F, Resti M, Giacchino R, Crivellaro C, Zancan L, Azzari C, et al.: Changing epidemiologic pattern of chronic hepatitis C virus infection in Italian children. J Pediatr 1998, 133:378-381. These authors show that after the disappearance of posttransfusion hepatitis, vertical transmission is the main route of the spread of HCV during childhood.
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J Pediatr
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Bortolotti, F.1
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31
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American Academy of Pediatrics, Committee on Infectious Diseases: Hepatitis C virus infection. Pediatrics 1998, 101:481-485.
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32
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Chronic hepatitis in children after liver transplantation: Role of hepatitis C virus and hepatitis G virus infections
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Davison SM, Skidmore SJ, Collingham KE, Irving WL, Hubscher SG, Kelly DE: Chronic hepatitis in children after liver transplantation: role of hepatitis C virus and hepatitis G virus infections. J Hepatol 1998, 28:764-770.
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J Hepatol
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Davison, S.M.1
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Mc Diarmid SV, Conrad A, Ament ME, Vargas J, Martin MG, Goss JA, Busuttil RW: De novo hepatitis C in children after liver transplantation. Transplantation 1998, 66:311-318. These authors analyze prevalence and outcome of de novo HCV infection in relation to interferon treatment.
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Transplantation
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Mc Diarmid, S.V.1
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34
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A review of hepatitis C virus (HCV) vertical transmission: Risks of transmission to infants born to mothers with and without HCV viraemia or human immunodeficiency virus infection
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Thomas SL, Newel ML, Peckham CS, Ades AE, Hall AJ: A review of hepatitis C virus (HCV) vertical transmission: risks of transmission to infants born to mothers with and without HCV viraemia or human immunodeficiency virus infection. Int J Epidemiol 1998, 27:108-117.
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Int J Epidemiol
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Ebeling F: Epidemiology of the hepatitis C virus. Vox Sang 1998, 74:143-146.
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Bernard O: Mother-to-infant transmission of hepatitis C. Acta Gastroenterol Belg 1998, 61:192-194.
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Acta Gastroenterol Belg
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Interferon-alpha treatment of chronic hepatitis C virus infection in children
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Jonas MM, Ott MJ, Nelson S, Badizadegan K, Perez-Atayde A: Interferon-alpha treatment of chronic hepatitis C virus infection in children. Pediatr Infect Dis J 1998, 17:241-246.
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Pediatr Infect Dis J
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Vegnente A, Iorio R, Pensati P: Treatment of pediatric hepatitis C: results and perspectives. Acta Gastroenterol Belg 1998, 61:235-236.
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Acta Gastroenterol Belg
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39
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Favorable response to lymphoblastoid interferon alpha in children with chronic hepatitis C
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Sawada A, Tajiri H, Kozaiwa K, Guo W, Tada K, Etani Y, et al.: Favorable response to lymphoblastoid interferon alpha in children with chronic hepatitis C. J Hepatol 1998, 28:184-188.
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J Hepatol
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al-Tawil Y, Nelson C: Interferon treatment of children with chronic hepatitis C. Hepatogastroenterology 1998, 345:541-548.
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Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
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McHutchison JG, Gordon SC, Schiff ER, Shiffman ML, Lee WM, Rustgi VK, et al.: Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N Engl J Med 1998, 339:1485-1492. These authors provide clear data on a large series of naive patients with chronic hepatitis C in two groups: one group treated with monotherapy (interferon alfa-2b), compared with a second group treated with a combination of interferon alfa-2b and ribavirin.
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N Engl J Med
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McHutchison, J.G.1
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Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C
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Davis GL, Esteban-Mur R, Rustgi V, Hoefs J, Gordon SC, Trepo C, et al.: Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. N Engl J Med 1998, 339: 1493-1499. The authors of this large study demonstrate that combination treatment is superior to interferon monotherapy in the retreatment of patients in whom chronic hepatitis C has relapsed.
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N Engl J Med
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Davis, G.L.1
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Feasibility and efficacy of routine PCR screening of blood donations for hepatitis C virus, hepatitis B virus, and HIV-1 in a blood-bank setting
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Roth WK, Weber M, Seifried E: Feasibility and efficacy of routine PCR screening of blood donations for hepatitis C virus, hepatitis B virus, and HIV-1 in a blood-bank setting. Lancet 1999, 353:359-363.
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(1999)
Lancet
, vol.353
, pp. 359-363
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Roth, W.K.1
Weber, M.2
Seifried, E.3
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