Accumulation of DNA damage in pre- and posthepatectomized liver of aged rats

Mechanisms of Ageing and Development

Volumn 110, Issue 1-2, 1999, Pages 25-35

  Kalandarishvili, Felix ^a   Wheeler, Kenneth T ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Aged Fisher 344 rats; DNA damage; DNA damage hypothesis of aging; DNA repair; Ionizing radiation; Pre and posthepatectomized rat liver

Indexed keywords

AGE; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; IONIZING RADIATION; LIVER CELL; LIVER RESECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RAT;

AGING; ANIMALS; DNA; DNA DAMAGE; DNA REPAIR; HEPATECTOMY; LIVER; MALE; RATS; RATS, INBRED F344;

EID: 0032825076     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(99)00039-1     Document Type: Article

References (33)

1. Alexander P. Accelerated aging - a long term effect of exposure to ionizing radiations. Gerontologia. 1:1957;174-193.
2. Alexander P. The role of DNA lesions in processes leading to aging in mice. Symp. Soc. Exp. Biol. 21:1967;29-50.
3. Al-Nabulsi I., Wheeler K.T. Temperature dependence of radiation-induced DNA-protein crosslinks formed under hypoxic conditions. Radiat. Res. 148:1997;568-574.
4. Al-Nabulsi I., Wheeler K.T. Temperature dependence of radiation-induced DNA damage in tumors and normal tissues: V. influence of pH and nutrient depletion on the formation of DNA-protein crosslinks in irradiated partially and fully hypoxic tumor cells. Radiat. Res. 151:1999;188-194.
5. Bergtold D.S., Lett J.T. Alterations in chromosomal DNA and aging: an overview. Sohal R.S., Birnbaum L.S., Cutler R.G. Molecular Biology of Aging: Gene Stability and Gene Expression. 1985;23-26 Raven Press, New York.
6. Berkowitz E.M., Sanborn A.C., Vaughan D.W. Chromatin structure in neuronal and neuroglial cell nuclei as a function of age. J. Neurochem. 41:1983;516-523.
7. Cesarone C.F., Bolognesi C., Santi L. Improved microfluorometric DNA determination in biological material using 33258 Hoechst. Anal. Biochem. 100:1979;188-197.
8. Curtis H.J., Leith J., Tilley J. Chromosome aberrations in the liver of dogs of different ages. J. Gerontol. 21:1966;268-270.
9. Fraga C.G., Shigenaga M.K., Park J.W., Degan P., Ames B.N. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA. 87:1990;4533-4537.
10. Fu C.S., Harris S.B., Wilhelmi P., Walford R.L. Lack of an effect of age and dietary restriction on DNA single-stranded breaks in brain, liver and kidney of (C3H×C57BL/10) F1 mice. J. Gerontol. 46:1991;B78-B80.
11. Gaubatz J., Ellis M., Chalkley R. The structural organization of mouse chromatin as a function of age. Fed. Proc. 38:1979;1973-1978.
12. Genzler H.L., Berstein H. DNA damage as the primary cause of aging. Q. Rev. Biol. 56:1981;279-303.
13. Higami Y., Shimakawa I., Okimoto T., Ikeda T. Vulnerability to oxygen radicals is more important than impaired repair in hepatocytic deoxyribonucleic acid damage in aging. Lab. Invest. 71:1994;650-656.
14. Higgins G.M., Anderson R.M. Experimental pathology of liver. I. Restoration of the liver of the white rats following surgical removal. Arch. Pathol. 12:1931;186-202.
15. Holmes G.E., Bernstein C., Bernstein H. Oxidative and other DNA damages as the basis of aging: a review. Mutat. Res. 275:1992;305-315.
16. Jaberaboansari A., Fletcher C., Wallen C.A., Wheeler K.T. Organization of DNA in cerebellar neurons of ageing unirradiated and irradiated rats. Mech. Ageing Dev. 50:1989;257-276.
17. Johnson R., Strehler B.L. Loss of genes coding for ribosomal RNA in aging brain cells. Nature. 240:1972;412-414.
18. Khilbock I.Y., Mozzhukhina T.G., Chabanney V.N., Kadura S.K. Some age-related structural peculiarities of fractionated chromatin. Gerontology. 29:1983;9-18.
19. Kohn K.W., Ewig R.A.G., Erickson L.C., Zwelling L.A. Measurement of strand breaks and crosslinks in DNA by alkaline elution. Friedberg E., Hanawalt P. DNA Repair: A Laboratory Manual of Research Procedures. 1981;379-402 Marcel Dekkar, New York.
20. Meyn R.E., Jenkins W.T. Variation in normal and tumor tissue sensitivity of mice to ionizing radiation-induced DNA strand breaks in vivo. Cancer Res. 43:1983;5668-5673.
21. Modak S.P., Gonet C., Unger-Ullmann C., Chappuis M. Chromatin structure in aging mouse liver. Experimentia. 34:1978;949.
22. Mullaart E., Boerrigter M.E.T.I., Brouwer A., Berends F., Vijg J. Age-dependent accumulation of alkali-labile sites in DNA of post-mitotic but not in that of mitotic rat liver cells. Mech. Ageing Dev. 45:1988;41-49.
23. Mullaart E., Boerrigter M.E.T.I., Boer G.J., Vijg J. Spontaneous DNA breaks in the rat brain during development and aging. Mutat. Res. 237:1990;9-15.
24. Park J.W., Ames B.N. 7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection. Proc. Natl. Acad. Sci. USA. 85:1988;7467-7470.
25. Price G.B., Modak S.P., Makinodan T. Age-associated changes in the DNA of mouse tissue. Science. 171:1971;917-920.
26. St. Clair W.H., Dwarakanath B.S., Zhang H., Wheeler K.T. Influence of proliferation on DNA repair rates in liver. Exp. Cell Res. 197:1991;323-325.
27. Walburg H.E. Radiation-induced life-shortening and premature aging. Adv. Radiat. Biol. 5:1975;145-179.
28. Wheeler K.T., Lett J.T. On the possibility that DNA repair is related to age in non-dividing cells. Proc. Natl. Acad. Sci. USA. 71:1974;1862-1865.
29. Wheeler K.T., Wierowski J.V. DNA repair kinetics in irradiated undifferentiated and terminally differentiated cells. Radiat. Environ. Biophys. 22:1983;3-19.
30. Wheeler K.T., Weinstein R.E., Kaufman K., Ritter P. Structural alterations of the DNA in cerebellar neurons after whole-brain irradiation. Radiat. Res. 85:1981;465-471.
31. vanAnkeren S.C., Wheeler K.T. Effect of alkali on the size dispersity of mammalian DNA measured by filter elution. Biophys. J. 45:1984;421-429.
32. Zhang H., Wheeler K.T. Radiation-induced DNA damage in tumors and normal tissues. I. Feasibility of estimating the hypoxic fraction. Radiat. Res. 136:1993;77-83.
33. Zonga V., Mathias A.P. The variation with age of the structure of chromatin in three cell types from rat liver. Biochem. J. 179:1979;291-298.