Biochemical effects of chlorpromazine on mouse neuroblastoma cells

Veterinary and Human Toxicology

Volumn 41, Issue 5, 1999, Pages 273-278

  Andres, Maria Isabel ^a,b   Repetto, Guillermo ^a,b   Sanz, Pilar ^a   Repetto, Manuel ^a,b  

^a Biology Section Apdo 863 E 41080   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ACETYLCHOLINESTERASE; BETA GALACTOSIDASE; CHLORPROMAZINE; ENOLASE; SUCCINATE DEHYDROGENASE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HICCUP; LYSOSOME; MOUSE; NAUSEA; NEUROBLASTOMA CELL; NONHUMAN; VOMITING;

ANIMALS; ANTIPSYCHOTIC AGENTS; CELL DIVISION; CHLORPROMAZINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; NEUROBLASTOMA; PROTEINS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0032824919     PISSN: 01456296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Reynolds JEF: Martindale: The Extra Pharmacopoeia, 28th Ed. The Pharmaceutical Press, London: 1982.
2. Bass RR, Vargas J: The Antipsychotic Drugs. In MD Haddad, J Winchester: Clinical Management of Poisoning and Drug Overdose, 2nd Ed. Saunders, Philadelphia: 1990.
3. Ellenhorn MJ: Neuroleptic drugs. In Ellenhorn's Medical Toxicology, 2nd Ed. Williams & Wilkins, Baltimore: 662-683, 1997.
4. Sekar MC, Roufogalis BD: Allosteric Regulation of Acetylcholinesterase. The Pharmstudent XX: 107, 1980.
5. Holmsen H, Rygh T: Chlorpromazine makes the platelet plasma membrane permeable for low-molecular weight substances and reduces ATP production. Biochem Pharmacol 40: 373-376, 1990.
6. Burkhardt C, Kelly JP, Lim YH et al: Neuroleptic medications inhibit comples I of the electron transport chain. Ann Neurol 33: 512-517, 1993.
7. Ogata N, Narahashi T: Potent blocking action of chlorpromazine on two types of calcium channels in cultured neuroblastoma cells. J Pharmacol Exp Ther 252: 1142-1149, 1990.
8. Henry JA, Cassidy SL: Membrane stabilizing activity: A major cause of fatal poisoning. The Lancet: 1414-1417, 1986.
9. Shopsis C, Eng B: Rapid cytotoxicity testing using semi-automated protein determination on cultured cells. Toxicol Lett 26: 1-8, 1985.
10. Bradford M: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 246, 1976.
11. Repetto G, Sanz P: Neutral red uptake, cellular growth and lysosomal function: In vitro effects of 24 metals. Alternatives To Laboratory Animals 21: 501-507, 1993.
12. Borenfreund E, Babich H, Martin-Alguacil N: Comparisons of two in vitro cytotoxicity assays. The Neutral Red (NR) and tetrazolium MTT tests. Toxicol in Vitro 2: 1-6, 1988.
13. Ling KH, Paetkau V, Marcus F et al: Phosphofructokinase (I. Skeltal Muscle). Methods in Enzymology IX: 425-426, 1996.
14. Andres MI, Repetto G, Sanz P et al: Simple Determination of Phosphofructokinase and Enolase Activities on Cultured Mouse Neuroblastoma Cells: Application to the in vitro Detection of Chemical Effects. Alternatives To Laboratory Animals 24: 63-71, 1996.
15. Marangos PJ, Zomzely-Neurath C, York C: Determination and characterization of Neuron Specific Protein (NSP) associated enolase activity. Biochem Biophy Res Com 68: 1309-1316, 1976.
16. Mosmann T: Rapid colorimetric assay for cellular growth and survival; Application to proliferation and cytotoxicity assays. J Immunological Methods 65: 55-63, 1983.
17. Repetto G, Sanz P, Repetto M: Comparative In Vitro Effects of Sodium Arsenite and Sodium Arsenate on Neuroblastoma Cells. Toxicology 92: 143-153, 1994.
18. Kresse H, Figura KV, Klein et al: Enzymic diagnosis of the genetic mucopolysaccharide storage disorders. Methods in Enzymology 83: 565-566, 1982.
19. Andres MI, Repetto G, Sanz P et al: Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetic acid on mouse neuroblastoma cells in vitro. Toxicology 109: 1-10, 1996.
20. Ellman GL, Courtney KD, Andres V Jr et al: A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmac 7: 88-95, 1961.
21. Hait WN, Lee CL: Characteristics of the cytotoxic effects of the phenothiazine class of calmodulin antagonists. Biochem Pharmacol 34: 3973-3978, 1985.
22. Edstrom A, Erkell LJ, Hansson HA: Reversal of morphological differentiation of mouse neuroblastoma cells by mitosis-inhibitors and anesthetics. Virchows Arch B Cell Pathol 7: 19: 101-113, 1975.
23. Hait WN, Cesmonde JF, Lazo JS: Effect of anti-ealmodulin drugs on the growth and sensitivity of C6 rat glioma cells to bleomycin. Anticancer Res 14: 1711-1721, 1994.
24. Shaikh NA, Downar E, Butany J: Amiodarone-an inhibitor of phospholipase activity: A comparative study of the inhibitory effects of amiodarone, chloroquine and chlorpromazine. Mol Cell Biochem 76: 163-172, 1987.
25. Bailey DN, Cuba JJ: Gas-chromatographic analysis for chlorpromazine and some of its metabolites in human serum, with use of a nitrogen detector. Clin Chem 25: 1211-1215, 1979.
26. LaManna JC: Intracellular pH determination by absortion spectrophotometry of neutral red. Metab Brain Dis 2: 167-182, 1987.
27. Litinskaia LL, Ogloblina TA, Veksler AM et al: Further comment on the usefullness of neutral red for measuring the pH of cells and cellular organoids. Tsitologiia 29: 120-124, 1987.
28. Sick TJ, Whittingham TS, LaManna JC: Determination of intracellular pH in the in vitro hippocampal slice preparation by trasilumination spectrophotometry of neutral red. J Neurosci Methods 27: 25-34, 1989.
29. Ollinger K, Brunk UT: Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radical Biology Medicine 19: 565-574, 1995.
30. Dewar AJ: Neurotoxicity. In M Balls, RJ Riddell, AN Worden: Animals and Alternatives in Toxicity Testing. Academic Press, London: 1983.