A prospective randomized study comparing intramuscular with intravaginal natural progesterone in programmed thaw cycles

Human Reproduction

Volumn 14, Issue 10, 1999, Pages 2596-2599

  Lightman, A ^a   Kol, J ^b   Itskovitz Eldor, ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Cryopreservation; Human embryos; Natural progesterone; Thaw cycle; Vaginal route of administration

Indexed keywords

ESTRADIOL; ESTROFEM; PROGESTERONE;

ABORTION; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYOPRESERVATION; EMBRYO TRANSFER; ENDOMETRIUM; FEMALE; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVAGINAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; NIDATION; ORAL DRUG ADMINISTRATION; PREGNANCY RATE; PROGESTERONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; THAWING;

EID: 0032824243     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/14.10.2596     Document Type: Article

References (20)

1. Bourgain, C, Devroey, P., Van Waesberghe, L. et al. (1990) Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure. Hum. Reprod., 5, 537-543.
2. Bourgain, C., Smitz, J., Camus, M. et al. (1994) Human endometrial maturation is markedly improved after luteal supplementation of gonadotrophin-releasing hormone analogue/human menopausal gonadotrophin stimulated cycles. Hum. Reprod., 9, 32-40.
3. Bulletti, C., de Ziegler, D., Flamigni, C. et al. (1997) Targeted drug delivery in gynaecology: the first uterine pass effect. Hum. Reprod., 12, 1073-1079.
4. Fanchin, R., de Ziegler, D., Bergeron, C. et al. (1997) Trans-vaginal administration of progesterone. Obstet. Gynecol., 90, 396-401.
5. Gibbons, W.E., Toner, J.P., Harnacher, P. and Kolm, P. (1998) Experience with novel vaginal progesterone preparation in a donor oocyte prosram. Fertil. Steril., 69, 96-101.
6. Lelaidier, C., de Ziegler, D., Gaetano, J. et al. (1992) Controlled preparation of the endometrium with exogenous estradiol and progesterone: a novel regimen not using a gonadotrophin-releasins hormone agonist. Hum. Reprod., 7, 1353-1356.
7. Lelaidier, C., de Ziegler, D., Freitas, S. et al. (1995) Endometrium preparation with exogenous estradiol and progesterone for the transfer of cryopreserved blastocysts. Fertil. Steril., 63, 919-921.
8. Lightman, A., Kol, S., Wayner, V. et al. (1997) The presence of a sponsoring embryo in a batch of poor quality thawed embryos significantly increases pregnancy and implantation rate. Fertil. Steril., 67, 711-716.
9. Miles, R.A., Paulson, R.J., Lobo, R.A. et al. (1994) Pharmacokinetics and endometrial tissue levels of progesterone after administration by i.m. and vaginal routes: a comparative study. Fertil. Steril., 62, 485-490.
10. Pattinson, H.A., Greene, C.A., Fleetham, J. and Anderson-Sykes, S.J. (1992) Exogenous control of the cycle simplifies thawed embryo transfer and results in pregnancy rate similar to that for natural cycles. Fertil. Steril., 58, 627-629.
11. Perino, M., Brigandi, F.G., Abate, F.G. et al. (1997) Intramuscular versus vaginal progesterone in assisted reproduction: a comparative study. Clin. Exp. Obstet. Gynecol., 24, 228-231.
12. Queenan, J.T. Jr, Ramey, J.W., Seltman, H.J. et al. (1997) Transfer of cryopreserved-thawed pre-embryos in a cycle using exogenous steroids without prior gonadotrophin-releasing hormone agonist suppression yields favorable pregnancy results. Hum. Reprod., 12, 1176-1180.
13. Sathanandan, M., Macnamee, M.C., Rainsbury, P. et al. (1991) Replacement of frozen-thawed embryos in artificial and natural cycles: a prospective semi-randomized study. Hum. Reprod., 6, 685-687.
14. Sauer, M.V., Stein, A.L., Paulson, R.J. and Moyer, D.L. (1991) Endometrial responses to various hormone replacement regimens in ovarian failure patients preparing for embryo donation. J. In Vitro. Fert. Embryo. Trans., 35, 61-68.
15. Serhal, P. and Craft, I. (1987) Simplified treatment for ovum donation. Lancet, i, 687-688.
16. Simon, A., Hurwitz, A., Zentner, B.S. et al. (1998) Transfer of frozen-thawed embryos in artificially prepared cycles with and without prior gonadotrophin-releasing hormone agonist suppression: a prospective randomized study. Hum. Reprod., 13, 2712-2717.
17. Simon, J.A., Robinson, D.E., Andrews, M.C. et al. (I993) The absorption of oral micronizcd progesterone: the effect of food, dose proportionality, and comparison with i.m. progesterone. Fertil. Steril., 60, 26-33.
18. Smitz, J., Devroey, P., Faguer, B. et al. (1992) A prospective randomized comparison of i.m. or intravaginal natural progesterone as a luteal phase and early pregnancy supplement. Hum. Reprod., 7, 168-175.
19. Templeton, A., and Morris, J.K. (1998) Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization. N. Engt. J. Med., 339, 573-577.
20. Veeck, L.L. (1990) The morphological assessment of human oocytes and early concepti. In Keel, B.A., Webster, B.W. (eds), CRC Handbook of the Laboratory Diagnosis and Treatment of Infertility. CRC Press, Boca Raton, pp. 365-367.