Kininogen and prekallikrein increases in the blood of streptozotocin- diabetic rats are normalized by insulin in vivo and in vitro

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 360, Issue 2, 1999, Pages 217-220

  Rothschild, Adolfo M ^a,b   Melo, Valeria L ^a   Reis, Marina L ^a   Foss, Milton C ^a   Gallo Jr , L ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

Bradykinin; Insulin; Kininogen; Prekallikrein; Streptozotocin diabetes

Indexed keywords

BRADYKININ; HUMAN INSULIN; INSULIN; KININOGEN; PREKALLIKREIN; PROTEINASE; TRYPSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; INSULIN BLOOD LEVEL; INSULIN RELEASE; KIDNEY FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; STREPTOZOCIN DIABETES;

ANESTHESIA; ANIMALS; BLOOD GLUCOSE; BRADYKININ; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FASTING; INSULIN; KININOGENS; MALE; PREKALLIKREIN; RATS; RATS, WISTAR; TIME FACTORS; TRYPSIN;

EID: 0032824164     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900068     Document Type: Article

References (21)

1. Bhoola KD, Figueiroa CD, Worthy K (1992) Bioregulation of kinins: kullikreins, kininogens and kininases. Pharmacol Rev 44:1-80
2. Cavalot F, Anfossi G, Russo T, Mularoni E, Massucco P, Burzacca S, Mattiello L, Trovati M (1992) Insulin, at physiological concentrations, enhances the polymorphonuclear leukocyte chemotactic properties. Horm Metab Res 24:225-228
3. Damas J, Bourdon V, Lefebre PJ (1998) Insulin release and sensitivity in kininogen deficient rats. XV International conference on kinins, Nara, Abstr P1-P10
4. De la Cadena RA, Scott C F, Colinan RW (1987) Evaluation of microassay for human prekallikrein. J Lab Clin Med 109:601-607
5. Dubowsky KM (1962) An o-toluidine method for body fluid glucose determination. Clin Chem 8:215-235
6. Duekworth WC (1988) Insulin degradation: mechanism, products and significance. Endocrinol Rev 9:319-345
7. Henderson LM, Figueiroa CD, Muller-Esterl W, Bhoola KD (1994) Assembly of contact phase activators on the surface of the human neutrophil membrane. Blood 84:474-482
8. 2 in rats with streptozotocin-induced diabetes. Naunyn-Schmiedeberg's Arch Pharmacol 322:290-294
9. Jaffa AA, Miller DH, Bailey GS, Chao J, Margolius HS, Mayfield RK (1987) Abnormal regulation of renal kallikrein in experimental diabetes. Effects of insulin on prokallikrein synthesis and activation. J Clin Invest 80:1651-1659
10. Jaffa AA, LeRoit D, Roberts CT Jr, Mayfield RK (1994) Insulin-like growth factor I produces renal hyperfiltration by a kinin-mediated mechanism. Am J Physiol 266:F102-F107.
11. Junod A, Lambert AE, Orezi L, Pictet R, Gonet AE, Renold AF. (1967) Studies of the diabetogenic action of streptozotocin. Proc Soc Exp Biol Med 126:201-205
12. Lowry OH, Rosebrough NJ, Farr AI, Randall RJ (1951) Protein measurement with Folin phenol reagent. J Biol Chem 193:265-275
13. Majima M, Sunahara N, Harada Y, Katori M (1993) Detection of degradation products of bradykinin by enzyme immunoassays as markers for the release of kinin in vivo. Biochem Pharmacol 45:559-567
14. Reis ML, Pascholato R, Serra CH (1992) Kininogen changes in the alloxan-diabetic rat. Agents Actions 36[Suppl]:223-229
15. Rothschild AM, Boden G, Colman RW (1996) Kininogen changes in human plasma following a test meal or insulin administration. Am J Physiol 270:H1071-H1077
16. Rothschild AM, Gomes ELT, Fortunato IC (1998) Bradykinin release from high molecular weight kininogen and increase in plasma kallikrein-like activity following sensory stimulation by food in the rat. Naunyn-Schmiedeberg's Arch Pharmacol 358: 483-488
17. Rothschild AM, Reis ML, Melo VL, Foss MC, Gallo L Jr (1999) Increased kininogen levels observed in plasma of diabetic patients are corrected by the administration of insulin. Horm Metab Res 31:326-328
18. Serra CHR, Polizello ACM, Reis ML (1994) Evidence of high molecular weight kininogen increase in experimental diabetes (abstract). Can J Physiol Pharmacol 72:226
19. Shima C, Majima M, Katori M (1992) A stable metabolite Arg-Pro-Pro-Gly-Phe of bradykinin in the degradation pathway in human plasma. Jpn J Pharmacol 60:111-119
20. Tomlinson KC, Gardiner SM, Hebden A, Bennett T (1992) Functional consequences of streptozotocin-induced diabetes mellitus with particular reference to the cardiovascular system. Pharmacol Rev 44:103-150
21. Uchara S, Isogawa S, Sakamoto W, Hirayama A (1988) Kallikrein-kinin system in diabetic patients. Arzneimittelforschung 38:721-723