Large and small airway responses to procaterol hydrochloride administered through different extension devices in asthmatic patients

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 12, Issue 3, 1999, Pages 177-185

  Fontana, Giovanni A ^a,b   Lavorini, Federico ^a   Chiostri, Marco ^a   Castellani, Walter ^a   Boddi, Vieri ^a   Pistolesi, Massimo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Dipartimento di Area Critica Medico Chirurgica   (Italy)

Author keywords

Asthma; Bronchodilation; Spacer devices

Indexed keywords

METHACHOLINE; PROCATEROL;

ADULT; ARTICLE; ASTHMA; BRONCHODILATATION; BRONCHUS REACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; METERED DOSE INHALER; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 0032824106     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.1999.12.177     Document Type: Article

References (34)

1. British Thoracic Society, National Asthma Campaign, Royal College of Physician of London, et al. 1997. The British guidelines on asthma management. Thorax. 52 (Suppl 1):S1-21.
2. Newhouse, M.T., and M. Dolovich. 1986. Control of asthma by aerosols. N. Engl. J. Med. 315:870-874.
3. Pauwels, R., S. Newman, and L. Borgström. 1997. Airway deposition and airway effects of antiasthma drugs delivered from metered-dose inhalers. Eur. Respir. J. 10:2127-2138.
4. McFadden, E.R., Jr. 1995. Improper patient techniques with metered dose inhalers: Clinical consequences and solutions to misuse. J. Allergy Clin. Immunol. 96:278-283.
5. Newman, S.P., and M.T. Newhouse. 1996. Effect of add-on devices for aerosol drug delivery: Deposition studies and clinical aspects. J. Aerosol Med. 9:55-70.
6. Newman, S.P., F. Morén, D. Pavia, F. Little, and S.W. Clarke. 1981. Deposition of pressurised suspension aerosols inhaled through extension devices. Am. Rev. Respir. Dis. 124:317-320.
7. König, P. 1985. Spacer devices used with metered-dose inhalers. Breakthrough or gimmick? Chest. 88:277-284.
8. Lulling, J., J.P. Delwiche, K.G. Hidinger, and J. Prignot. 1983. Influence of different extension-actuator tubes on the bronchodilation effect of a terbutaline sulfate aerosol. Eur. J. Respir. Dis. 64:33-37.
9. Lee, H., and H.E. Evans. 1987. Evaluation of inhalation aids of metered dose inhalers in asthmatic children. Chest. 91:366-369.
10. Tobin, M.J., G. Jenouri, I. Danta, C. Kim, H. Watson, and M.A. Sackner. 1982. Response to bronchodilator drug administration by a new reservoir aerosol delivery system and a review of other auxiliary delivery systems. Am. Rev. Respir. Dis. 126:670-675.
11. Lindgren, S.B., H. Formgren, and F. Morén. 1980. Improved aerosol therapy of asthma: Effect of actuator tube size on drug availability. Eur. J. Respir. Dis. 61:56-61.
12. Fairshter, R.D. 1987. Evaluation of a metered-dose aerosol delivery system using partial flow-volume curves. Am. Rev. Respir. Dis. 135:741-743.
13. Postma, D.S., F. Gimeno, L.Th. Van der Weele, and H.J. Sluiter. 1985. Assessment of ventilatory variables in survival prediction of patients with chronic airflow obstruction: The importance of reversibility. Eur. J. Respir. Dis. 67:360-368.
14. 1. Eur. Respir. J. 5:975-981.
15. Mackay, A.D., C.P. Mustchin, and G.M. Sterling. 1981. The response of asthmatic patients and normal subjects to maximum respiratory manoeuvres. Eur. J. Respir. Dis. 61:35-40.
16. Fontana, G.A., S. Cardellicchio, G. Camiciottoli, P. Panuccio, and V. Boddi. 1993. Changes in transcutaneous oxygen partial pressure as an index of response to inhaled methacholine in asthmatic patients. Chest. 103:1375-1380.
17. Newman, S.P., D. Pavia, and S.W. Clarke. 1981. How should a pressurized β-adrenergic bronchodilator be inhaled? Eur. J. Respir. Dis. 62:3-21.
18. Kenyon, C.J., N.J. Dewsbury, and S.P. Newman. 1995. Differences in aerodynamic particle size distributions of innovator and generic beclomethasone dipropionate aerosols used with and without a large volume spacer. Thorax. 50:846-850.
19. Matthys, H., and A. Umile. 1997. Holding chambers for pMDI use. Drugs Exp. Clin. Res. 23:183-189.
20. American Thoracic Society. 1987. Standardization of spirometry-1987 update. Am. Rev. Respir. Dis. 136: 1285-1298.
21. Olsen, C.R., and F.C. Hale. 1968. A method for interpreting acute response to bronchodilators from the spirogram. Am. Rev. Respir. Dis. 98:301-302.
22. Altman, D.G. 1991. Serial measurements. In Practical Statistics for Medical Research. Chapman and Hall, London, 426-433.
23. American Thoracic Society. 1991. Lung function testing: Selection of reference values and interpretative strategies. Am. Rev. Respir. Dis. 144:1202-1218.
24. Epstein, S.W., J.E. Parsons, P.N. Corey, G.H. Worsley, and P.A. Reilly. 1983. A comparison of three means of pressurized aerosol inhaler use. Am. Rev. Respir. Dis. 128:253-255.
25. Newman, S.P., G. Woodman, S.W. Clarke, and M.A. Sackner. 1986. Effect of InspirEase on the deposition of metered-dose aerosols in the human respiratory tract. Chest. 89:551-556.
26. Kim, C.S., M.A. Eldridge, and M.A. Sackner. 1987. Oropharyngeal deposition and delivery aspects of metered-dose inhaler aerosols. Am. Rev. Respir. Dis. 135:157-164.
27. Mitchell, D.M., M.A. Solomon, S.E.J. Tolfree, M. Short, and S.G. Spiro. 1987. Effect of particle size of bronchodilator aerosols on lung distribution and pulmonary function in patients with chronic asthma. Thorax. 42:456-461.
28. McFadden, E.R., Jr, and D.A. Linded. 1972. A reduction in maximum mid-expiratory flow rate. A spirographic manifestation of small airway disease. Am. J. Med. 52:725-737.
29. Dolovich, M., R. Ruffin, D. Corr, and M.T. Newhouse. 1983. Clinical evaluation of a simple demand inhalation MDI aerosol delivery device. Chest. 84:36-41.
30. Patel, P., D. Mukai, and A.F. Wilson. 1990. Dose-response effects of two sizes of monodisperse isoproterenol in mild asthma. Am. Rev. Respir. Dis. 141:357-360.
31. Lipworth, B.J. 1995. New perspectives on inhaled drug delivery and systemic bioactivity. Thorax. 50:105-110.
32. McFadden, E.R., Jr, R. Kiser, and W.J. DeGroot. 1973. Acute bronchial asthma. Relations between clinical and physiologic manifestation. N. Engl. J. Med. 288:221-225.
33. Barry, P.W., and C. Callaghan. 1996. Inhalation drug delivery from seven different spacer devices. Thorax. 51:835-840.
34. Dolovitch, M., P. Eng, R. Ruffin, D. Corr, and M.T. Newhouse. 1983. Clinical evaluation of simple demand inhalation MDI aerosol delivery device. Chest. 84:36-41.