Involvement of serotonin 2A receptors in phencyclidine-induced disruption of prepulse inhibition of the acoustic startle in rats

Biological Psychiatry

Volumn 46, Issue 6, 1999, Pages 832-838

  Yamada, Shigeto ^a   Harano, Mutsuo ^a   Annoh, Naoko ^a   Nakamura, Kaoru ^b   Tanaka, Masatoshi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Hizen National Hospital   (Japan)

Author keywords

Apomorphine; Neuroleptics; Phencyclidine; Prepulse inhibition; Serotonin 2A receptor

Indexed keywords

APOMORPHINE; DOPAMINE 2 RECEPTOR; PHENCYCLIDINE; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY STIMULATION; CONTROLLED STUDY; MALE; NEUROMODULATION; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM; STARTLE REFLEX;

ANIMALS; ANTIPSYCHOTIC AGENTS; APOMORPHINE; AUDITORY PERCEPTION; BRAIN; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEART RATE; MALE; NEURAL INHIBITION; PHENCYCLIDINE; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; STARTLE REACTION;

EID: 0032823569     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00356-4     Document Type: Article

References (36)

1. Bakshi V.P., Geyer M.A. Phencyclidine-induced deficits in prepulse inhibition of startle are blocked by prazosin, an α-1 noradrenergic antagonist. J Pharmacol Exp Ther. 283:1997;666-674.
2. Bakshi V.P., Geyer M.A. Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine. Psychopharmacology. 122:1995;198-201.
3. Bakshi V.P., Swerdlow N.R., Geyer M.A. Clozapine antagonizes phencyclidine-induced deficits in sensorymotor gating of the startle response. J Pharm Exp Ther. 271:1994;787-794.
4. Braff D., Stone C., Callaway E., Geyer M., Glick I., Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology. 15:1978;339-343.
5. Bymaster F.P., Calligaro D.O., Falcone J.F., et al. Radioreveptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 14:1996;87-96.
6. Gleason S.D., Shannon H.E. Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin subtype selective antagonists in mice. Psychopharmacology. 129:1997;79-84.
7. Graham F. The more or less startling effects of weak prestimulation. Psychophysiology. 12:1975;238-248.
8. Hernandez L., Auerbach S., Hoebel B.G. Phencyclidine (PCP) injected in the nucleus accumbens increases extracellular dopamine and serotonin as measured by microdialysis. Life Sci. 42:1988;1713-1723.
9. Hoffman D.A., Donovan H., Cassella J.V. The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801. Psychopharmacology. 111:1993;339-344.
10. Hori T., Suzuki T., Baba A., et al. Effects of phencyclidine metabolites on serotonin uptake in rat brain. Neurosci Lett. 209:1996;153-156.
11. Johansson C., Jackson D.M., Zhang J., Svensson L. Prepulse inhibition of acoustic startle, a measure of sensorimotor gating Effects of antipsychotics and other agents in rats . Pharmacol Biochem Behav. 52:1995;649-654.
12. Keith V.A., Mansbach R.S., Geyer M.A. Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle. Biol Psychiatry. 30:1991;557-566.
13. Kodsi M.H., Swerdlow N.R. Ventral pallidal GABA-A receptors regulate prepulse inhibition of acoustic startle. Brain Res. 684:1995;26-35.
14. Krystall J.H., Seibyl J.P., Price L.H., et al. M-chlorophenylpiperadine (MCPP) effects in neuroleptic-free schizophrenic patients. Arch Gen Psychiatry. 50:1993;624-635.
15. 2 receptor binding sites. Mol Pharmacol. 21:1982;301-314.
16. Lillrank S.M., O'Connor W.T., Oja S.S., Ungerstedt U. Systemic phencyclidine administration is associated with increased dopamine, GABA and 5-HIAA levels in the dorsolateral striatum of conscious rats An in vivo microdyalysis study . J Neural Transm Gen Sect. 95:1994;145-155.
17. Lipska B.K., Swerdlow N.R., Geyer M.A., Jaskiw G.E., Braff D.L., Weinberger D.R. Neonatal excitotoxic hippocampal damage in rats caused post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology. 122:1995;35-43.
18. Loscher W., Annies R., Honack D. The N-methyl-D-aspartate receptor antagonist MK-801 induces increases in dopamine and serotonin metabolism in several brain regions of rats. Neurosci Lett. 128:1991;191-194.
19. Marshall B.D., Glynn S.M., Midha K.K., et al. Adverse effects of fenfluramine in treatment refractory schizophrenia. J Clin Psychopharmacol. 9:1989;110-115.
20. Maurel R.S., Bervoets K., Millan M.J. Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors. Eur J Pharmacol. 280:1995;R9-R11.
21. 2 receptor-mediated behavior in rats. Neurosci Lett. 76:1987;335-338.
22. Nabeshima T., Yamaguchi K., Hiramatsu M., Amano M., Furukawa H., Kameyama T. Serotonergic involvement in phencyclidine-induced behaviors. Pharmacol Biochem Behav. 21:1984;401-408.
23. Ohno Y., Warnick J.E. Presynaptic activation of the spinal resotonergic system in the rat by phencyclidine. J Pharm Exp Ther. 250:1989;177-183.
24. Peroutka S.J., Snyder S.H. Relationship of neuroleptic drug effects at brain dopamine, serotonin, α-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry. 137:1980;1518-1522.
25. Roth B.L., Meltzer H.Y. The role of serotonin in schizophrenia. Bloom F.E., Kupfer D.J. Psychopharmacology, The Fourth Generation of Progress. 1995;1215-1227 Raven Press, New York.
26. Seeman P. Dopamine receptors, clinical correlates. Bloom F.E., Kupfer D.J. Psychopharmacology, The Fourth Generation of Progress. 1995;295-302 Raven Press, New York.
27. Sipes T.A., Geyer M.A. Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats. Neuropharmacology. 33:1994;441-448.
28. 2A receptors in the ventral pallidum. Brain Res. 761:1997;97-104.
29. Swerdlow N.R., Bakshi V., Geyer M.A. Seroquel restores sensorimotor gating in phencyclidine-treated rats. J Pharmacol Exp Ther. 279:1996;1290-1299.
30. Swerdlow N.R., Braff D.L., Taaid N., Geyer M.A. Assesing the validity of an animal model of deficit sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry. 51:1994;139-154.
31. Swerdlow N.R., Keith V.A., Braff D.L., Geyer M.A. Effect of spiperone, raclopride, SCH23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat. J Pharmacol Exp Ther. 256:1991;530-536.
32. Varty G.B., Higgins G.A. Reversal of dizocilpine-induced disruption of prepulse inhibition of an acoustic startle response by the 5-HT 2 receptor antagonist ketanserin. Eur J Pharmacol. 287:1995;201-205.
33. Varty G.B., Higgins G.A. Examination of drug-induced and isolation-induced disruption of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology. 122:1995;15-26.
34. Wan F.J., Geyer M.A., Swedlow N.R. Presynaptic dopamine-glutamate interaction in the nucleus accumbens regulate sensorimotor gating. Psychopharmacology. 120:1995;433-441.
35. Yamada S., Harano M., Tanaka M. Dopamine autoreceptors in rat nucleus accumbens modulate prepulse inhibition of acoustic startle. Pharmacol Biochem Behav. 60:1998;803-808.
36. 2 receptors in reserpinized rats. Neuropharmacology. 26:1987;1489-1497.