Enhanced hepatocyte uptake and liver targeting of methotrexate using galactosylated albumin as a carrier

International Journal of Pharmaceutics

Volumn 188, Issue 1, 1999, Pages 39-47

  Han, Jung Hee ^a   Oh, Yu Kyoung ^a   Kim, Dong Sup ^b   Kim, Chong Kook ^a  

^a Seoul National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

Author keywords

Drug carrier; Liver targeting; Methotrexate; Methotrexate galactosylated albumin conjugates; Pharmacokinetics; Tissue distribution

Indexed keywords

ALBUMIN CONJUGATE; GALACTOSYLALBUMIN; METHOTREXATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG RELEASE; DRUG TARGETING; DRUG UPTAKE; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CATTLE; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; GALACTOSE; LIVER; MALE; METHOTREXATE; RATS; RATS, WISTAR; SERUM ALBUMIN, BOVINE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0032822827     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00206-9     Document Type: Article

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