Killing activities of trovafloxacin alone and in combination with β- lactam agents, rifampin, or vancomycin against Streptococcus pneumoniae isolates with various susceptibilities to extended-spectrum cephalosporins at concentrations clinically achievable in cerebrospinal fluid

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 10, 1999, Pages 2372-2375

  Fitoussi, Frederic ^a   Doit, Catherine ^a   Geslin, Pierre ^b   Bingen, Edouard ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; BETA LACTAM ANTIBIOTIC; CEFOTAXIME; CEFPIROME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; MEROPENEM; PENICILLIN G; RIFAMPICIN; TROVAFLOXACIN; VANCOMYCIN;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL MENINGITIS; BACTERICIDAL ACTIVITY; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG CEREBROSPINAL FLUID LEVEL; DRUG POTENTIATION; GENOTYPE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

EID: 0032822670     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.10.2372     Document Type: Article

References (48)

1. American Academy of Pediatrics, Committee on Infectious Diseases. 1997. Therapy for children with invasive pneumococcal infections. Pediatrics 99: 289-299.
2. Arguedas-Mohs, A., S. L. Vargas for Chile PID-CRC Network Physicians, J. S. Bradley, C. Loaiza, R. Rivera, J. Vincent, R. Teng, and J. N. Walterspiel. 1997. Trovafloxacin CSF penetration and pharmacokinetics in children, abstr. A-105, p. 21. In Program and abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
3. Bingen, E., N. Lambert-Zechovsky, P. Mariani-Kurdjian, C. Doit, Y. Aujard, F. Fournerie, and H. Mathieu. 1990. Bacterial count in cerebrospinal fluid of children with meningitis. Eur. J. Clin. Microbiol. Infect. Dis. 9:278-281.
4. Bradley, J. S., and J. D. Connor. 1991. Ceftriaxone failure in meningitis caused by Streptococcus pneumoniae with reduced susceptibility to beta-lactams antibiotics. Pediatr. Infect. Dis. J. 10:871-873.
5. Bradley, J. S., and W. M. Scheld. 1997. The challenge of penicillin-resistant Streptococcus pneumoniae meningitis: current antibiotic therapy in the 1990s. Clin. Infect. Dis. 24(Suppl. 2):213-221.
6. Canton, E. 1993. Cefotaxime breakpoint for Streptococcus pneumoniae. Antimicrob. Agents Chemother. 37:616-617.
7. Cutler, N. R., J. Vincent, S. S. Jhee, R. Teng, T. Wardle, G. Lucas, L. C. Dogolo, and J. J. Sramek. 1997. Penetration of trovafloxacin into cerebro-spinal fluid in humans following intravenous infusion of alatrofloxacin. Antimicrob. Agents Chemother. 41:1298-1300.
8. Dagan, R., L. Velghe, J. L. Rodda, and K. P. Klugman. 1994. Penetration of meropenem into the cerebrospinal fluid in humans with inflamed meninges. J. Antimicrob. Chemother. 34:175-179.
9. Decazes, J. M., J. D. Ernst, and M. A. Sande. 1983. Correlation of in vitro time-kill curves and kinetics of bacterial killing in cerebrospinal fluid during ceftriaxone therapy of experimental Escherichia coli meningitis. Antimicrob. Agents Chemother. 24:463-467.
10. Doit, C., J. Barre, R. Cohen, S. Bonacorsi, A. Bourrillon, and E. Bingen. 1997. Bactericidal activity against intermediately cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with bacterial meningitis treated with high doses of cefotaxime and vancomycin. Antimicrob. Agents Chemother. 41:2050-2052.
11. Doit, C., S. P. Bonacorsi, A. J. Fremaux, G. Sissia, R. Cohen, P. L. Geslin, and E. H. Bingen. 1994. In vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis. Antimicrob. Agents Chemother. 38:2655-2659.
12. Doit, C., E. Denamur, B. Picard, P. Geslin, J. Elion, and E. Bingen. 1996. Mechanisms of spread of penicillin resistance in Streptococcus pneumoniae strains causing meningitis in children in France. J. Infect. Dis. 174:520-528.
13. Doit, C., C. Loukil, F. Fitoussi, P. Geslin, and E. Bingen. 1999. Emergence of multiple clones of clinical Streptococcus pneumoniae isolates with high level resistance to amoxicillin in France. Antimicrob. Agents Chemother. 43:1480-1483.
14. Eliopoulos, G. M., and R. C. Moellering, Jr. 1996. Antimicrobial combinations, p. 330-396. In V. Lorian (ed.), Antibiotics in laboratory medicine, 4th ed. The Williams & Wilkins Co., Baltimore, Md.
15. Fitoussi, F., C. Doit, K. Benali, S. Bonacorsi, P. Geslin, and E. Bingen. 1998. Comparative in vitro killing activities of meropenem, imipenem, and ceftriaxone plus vancomycin at clinically achievable cerebrospinal fluid concentrations against penicillin-resistant Streptococcus pneumoniae isolates from children with meningitis. Antimicrob. Agents Chemother. 42:942-944.
16. Friedland, I. R., M. Paris, S. Ehrett, S. Hickey, K. Olsen, and G. H. McCracken, Jr. 1993. Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob. Agents Chemother. 37:1630-1636.
17. Friedland, I. R., S. Shelton, M. Paris, S. Rinderknecht, S. Ehrett, K. Krisher, and G. H. McCracken, Jr. 1993. Dilemmas in diagnosis and management of cephalosporin-resistant Streptococcus pneumoniae meningitis. Pediatr. Infect. Dis. J. 12:196-200.
18. Giron, K. P., M. E. Gross, D. M. Musher, T. W. Williams, Jr., and R. A. Tharappel. 1995. In vitro antimicrobial effect against Streptococcus pneumoniae of adding rifampin to penicillin, ceftriaxone, or l-ofloxacin. Antimicrob. Agents Chemother. 39:2798-2800.
19. John, C. C. 1994. Treatment failure with use of third-generation cephalosporin for penicillin-resistant pneumococcal meningitis: case report and review. Clin. Infect. Dis. 18:188-193.
20. Johnson, A. P., D. M. Livermore, N. Woodford, A. Quoraishi, and R. Freeman. 1998. High level β-lactam resistance in strains of Streptococcus pneumoniae isolated in the UK. J. Antimicrob. Chemother. 42:115-116.
21. Kaplan, S. L., and E. O. Mason, Jr. 1998. Management of infections due to antibiotic-resistant Streptococcus pneumoniae. Clin. Microbiol. Rev. 11:628-644.
22. Kim, Y. S., Q. Liu, L. L. Chow, and M. G. Täuber. 1997. Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41:1186-1189.
23. Klugman, K. P., T. Capper, and A. Bryskier. 1996. In vitro susceptibility of penicillin-resistant Streptococcus pneumoniae to levofloxacin, selection of resistant mutants, and time-kill synergy studies of levofloxacin combined with vancomycin, teicoplanin, fusidic acid, and rifampin. Antimicrob. Agents Chemother. 40:2802-2804.
24. Klugsman, K. P., I. R. Friedland, and J. S. Bradley. 1995. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis. Antimicrob. Agents Chemother. 39:1988-1992.
25. Klugman, K. P., and T. D. Gootz. 1997. In-vitro and in-vivo activity of trovafloxacin against Streptococcus pneumoniae. J. Antimicrob. Chemother. 39(Suppl. B):51-55.
26. Latif, R., and A. S. Dajani. 1983. Ceftriaxone diffusion into cerebrospinal fluid of children with meningitis. Antimicrob. Agents Chemother. 23:46-48.
27. Lutsar, I., I. R. Friedland, L. Wubbel, C. C. McCoig, H. S. Jafri, N. G. Winston, F. Ghaffar, and G. H. McCracken, Jr. 1998. Pharmacodynamics of gatifloxacin in cerebrospinal fluid in experimental cephalosporin-resistant pneumococcal meningitis. Antimicrob. Agents Chemother. 42:2650-2655.
28. McDougal, L. K., J. K. Rasheed, J. W. Biddle, and F. Tenover. 1995. Identification of multiples clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States. Antimicrob. Agents Chemother. 39:2282-2288.
29. Munoz, R., T. J. Coffey, M. Daniels, C. G. Dowson, G. Laible, J. Casal, R. Hakenbeck, M. Jacobs, J. M. Musser, B. G. Spratt, and A. Tomasz. 1991. Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J. Infect. Dis. 164:302-306.
30. Munoz, R., C. G. Downson, M. Daniels, T. J. Coffey, C. Martin, R. Hakenbeck, and B. G. Spratt. 1992. Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Mol. Microbiol. 6:2461-2477.
31. Nahata, M. C., P. Fan-Havard, W. J. Barson, H. M. Bartkowski, and E. J. Kosnik. 1990. Pharmacokinetics, cerebrospinal fluid concentration, and safety of intravenous rifampin in pediatric patients undergoing shunt placements. Eur. J. Clin. Pharmacol. 38:515-517.
32. National Committee for Clinical Laboratory Standards. 1998. Performance for antimicrobial susceptibility testing. Eighth informational supplement. M100 S8. National Committee for Clinical Laboratory Standards, Wayne, Pa.
33. National Committee For Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 4th ed. Approved standard M7 A4. National Committee for Clinical Laboratory Standards, Wayne, Pa.
34. Nicolau, D. P., P. R. Tessier, R. Quintiliani, and C. H. Nightingale. 1998. Synergistic activity of trovaftoxacin and ceftriaxone or vancomycin against Streptococcus pneumoniae with various penicillin susceptibilities. Antimicrob. Agents Chemother. 42:991-992.
35. Nolan, C. M., E. G. Chalub, D. G. Nash, and T. Yamauchi. 1979. Treatment of bacterial meningitis with intravenous amoxicillin. Antimicrob. Agents Chemother. 16:171-175.
36. Pankuch, G. A., M. R. Jacobs, and P. C. Appelbaum. 1995. Activity of CP 99,219 compared with DU-6589a, ciprofloxacin, ofloxacin, levofloxacin, lomefloxacin, tosufloxacin, sparfloxacin and grepafloxacin against penicillin-susceptible and -resistant pneumococci. J. Antimicrob. Chemother. 35:230-232.
37. Paris, M. M., S. M. Hickey, M. Trujillo, S. Shelton, and G. H. McCracken, Jr. 1995. Evaluation of CP-99,219, a new fluoroquinolone, for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob. Agents Chemother. 39:1243-1246.
38. Paris, M. M., S. M. Hickey, M. I. Uscher, S. Shelton, K. D. Olsen, and G. H. McCracken, Jr. 1994. Effect of dexamethasone on therapy of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob. Agents Chemother. 38:1320-1324.
39. Paris, M. M., O. Ramilo, and G. H. McCracken, Jr. 1995. Management of meningitis caused by penicillin-resistant Streptococcus pneumoniae. Antimicrob. Agents Chemother. 39:2171-2175.
40. Rodoni, D., F. Hänni, C. M. Gerber, M. Cottagnoud, K. Neftel, M. G. Täuber, and P. Cottagnoud. 1999. Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model. Antimicrob. Agents Chemother. 43:963-965.
41. Sibold, C., J. Wang, J. Henrichsen, and R. Hackenbeck. 1992. Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents. Infect. Immun. 60:4119-4126.
42. Sloas, M. M., F. F. Barrett, P. J. Chesney, B. K. English, B. C. Hill, F. C. Tenover, and R. J. Leggiadro. 1992. Cephalosporin treatment failure in penicillin- and cephalosporin-resistant Streptococcus pneumoniae meningitis. Pediatr. Infect. Dis. J. 11:662-666.
43. Tauber, M. G., C. A. Doroshow, C. J. Hackbarth, M. G. Rusnak, T. A. Drake, and M. A. Sande. 1984. Antibacterial activity of β-lactam antibiotics in experimental meningitis due to Streptococcus pneumoniae. J. Infect. Dis. 149:568-574.
44. Thomson, K. S., S. A. Chartrand, C. C. Sanders, and S. L. Block. 1997. Trovafloxacin, a new fluoroquinolone with potent activity against Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41:478-480.
45. Viladrich, P., F. Gudiol, J. Liñares, G. Rufi, J. Ariza, and R. Pallares. 1988. Characteristics and antibiotic therapy of adult meningitis due to penicillin-resistant pneumococci. Am. J. Med. 84:839-846.
46. Visalli, M. A., M. R. Jacobs, and P. C. Appelbaum. 1996. Activity of CP 99,219 (trovafloxacin) compared with ciprofloxacin, sparfloxacin, clinafloxacin, lomefloxacin and cefuroxime against ten penicillin susceptible and penicillin-resistant pneumococci by time-kill methodology. J. Antimicrob. Chemother. 37:77-84.
47. Wolff, M., P. Chavanet, A. Kazmierczak, A. Pechinot, C. Dematons, H. Portier, and B. Lenfant. 1992. Diffusion of cefpirome into the cerebrospinal fluid of patients with purulent meningitis. J. Antimicrob. Chemother. 29(Suppl. A):59-62.
48. Yourassovsky, E., M. P. Van der Linden, F. Crokaert, and Y. Glupczynski. 1988. Effect of antibiotics carry-over on bacterial counting by spiral plating". J. Antimicrob. Chemother. 21:138-140.