Effects of large-scale limb deafferentation on the morphological and physiological organization of the forepaw barrel subfield (FBS) in somatosensory cortex (SI) in adult and neonatal rats

Experimental Brain Research

Volumn 128, Issue 3, 1999, Pages 315-331

  Pearson, Phillip P ^a   Li, Cheng X ^a   Waters, Robert S ^a  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Barrels; Cortical plasticity; Cortical reorganization; Deafferentation

Indexed keywords

CYTOCHROME C OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MAPPING; CONTROLLED STUDY; DEAFFERENTATION; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; EVOKED SOMATOSENSORY RESPONSE; FOREARM; FOREFOOT; LATENT PERIOD; LIMB; MORPHOLOGY; NEWBORN; NONHUMAN; ORGANIZATION; PLASTICITY; PRIORITY JOURNAL; RAT; SHOULDER; SOMATOSENSORY CORTEX; STAIN; WRIST;

AMPUTATION; ANIMALS; ANIMALS, NEWBORN; BRAIN MAPPING; DENERVATION; EVOKED POTENTIALS, SOMATOSENSORY; FORELIMB; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SHOULDER; SOMATOSENSORY CORTEX;

EID: 0032821454     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050852     Document Type: Article

References (40)

1. Angel A, Banks D (1978) The functional organization of the forepaw sensorimotor cortex in the adult rat. J Physiol 343:70-71
2. Armstrong-James M, Millar J (1979) Carbon fibre microelectrodes. J Neurosci Methods 1:279-287
3. Arnold PB, Li CX, Waters RS (1998) Thalamocortical axons in the vibrissa and forepaw barrel subfields (FBS) in rat primary somatosensory (SI) cortex project beyond individual barrels: an in-vivo intracellular recording and labeling study. Soc Neurosci Abstr 24:635
4. Bernardo KL, Woolsey TA (1987) Axonal trajectories between mouse somatosensory thalamus and cortex. J Comp Neurol 258:542-564
5. Carvell GE, Simons DJ (1988) Membrane potential changes on rat SmI cortical neurons evoked by controlled stimulation of mystical vibrissae. Brain Res 448:186-191
6. Casanova C, McKinley PA, Molotchnikoff S (1991) Responsiveness of reorganized primary somatosensory (SI) cortex after local inactivation of normal SI cortex in chronic spinal cats. Somatosens Mot Res 8:65-76
7. Chau CW, McKinley PA (1991) Chronological observations of primary somatosensory cortical maps in kittens following low thoracic (T12) spinal cord transection at 2 weeks of age. Somatosens Mot Res 8:355-376
8. Cusick CG, Wall JT, Shiting JH Jr., Wiley RG (1990) Temporal progression of cortical reorganization following nerve injury. Brain Res 537:355-358
9. Darian-Smith C, Gilbert CD (1994) Axonal sprouting accompanies functional reorganization in adult cat striate cortex. Science 368:737-740
10. Dawson DR, Killackey HP (1987) The organization and mutability of the forepaw and hindpaw representations in the somatosensory cortex of the neonatal rat. J Comp Neurol 256: 246-256
11. Donoghue JP, Sanes JN (1988) Organization of adult motor cortex representation patterns following neonatal forelimb nerve injury in rats. J Neurosci 8:3221-3232
12. Franck JI (1980) Functional reorganization of cat somatic sensory-motor cortex (SmI) after selective dorsal root rhizotomies. Brain Res 186:458-462
13. Garraghty PE, Kaas JH (1991) Large-scale functional reorganization in adult monkey cortex after peripheral nerve injury. Proc Natl Acad Sci USA 88:6976-6980
14. Hall RD, Lindholm EP (1974) Organization of motor and somatosensory neocortex in the albino rat. Brain Res 66:23-38
15. Jain N, Florence SL, Kaas JH (1995) Limits on plasticity in somatosensory cortex of adult rats: hindlimb cortex is not reactivated after dorsal column section. J Neurophysiol 73:1537-1546
16. Kalaska J, Pomeranz B (1979) Chronic paw denervation causes an age-dependent appearance of novel responses from forearm in "paw cortex" of kittens and adult cats. J Neurophysiol 42:618-633
17. Killackey HP, Dawson DR (1989) Expansion of the central hindpaw representation following fetal forelimb removal in the rat. Eur J Neurosci 1:210-221
18. Killackey HP, Leshin S (1975) The organization of specific thalamocortical projections to the posteromedial barrel subfield of the rat somatic sensory cortex. Brain Res 86:469-472
19. Lane RD, Bennett-Clarke CA, Chiaia NL, Killackey HP, Rhoades RW (1995) Lesion-induced reorganization in the brainstem is not completely expressed in somatosensory cortex. Proc Natl Acad Sci USA 92:4264-4268
20. Lane RD, Killackey HP, Rhoades RW (1997) Blockade of GABAergic inhibition reveals reordered cortical somatotopic maps in rats that sustained neonatal forelimb removal. J Neurophysiol 77:2723-2735
21. Li CX, Waters RS (1996) In vivo intracellular recording and labeling of neurons in the forepaw barrel subfield (FBS) of rat somatosensory cortex: possible physiological and morphological substrates for reorganization. Neuroreport 7:2261-2272
22. Li CX, Waters RS (1998) Removal of GABA-inhibition elevates subthreshold peripheral input to firing level in neurons in forepaw barrel subfield (FBS) in rat somatosensory cortex (Abstract). Somatosen Mot Res 15:75
23. Li CX, Waters RS, Oladehin A, Johnson EF, McCandlish CA, Dykes RW (1994) Large unresponsive zones appear in cat SI cortex immediately after ulnar nerve cut. Can J Neurol Sci 21: 233-247
24. McCandlish CA, Li CX, Howard EM, Johnson EJ, Waters RS (1995) Digit removal prior to postnatal day 5 (PND-5) results in a match between the morphological reorganization of the forepaw barrel subfield (FBS) and the representation of the forepaw in neonatal rat. Soc Neurosci Abstr 21:124
25. McCandlish CA, Li CX, Waters RS (1996) Digit removal leads to discrepancies between the structural and functional organization of the forepaw barrel subfield in layer IV of rat primary somatosensory cortex. Exp Brain Res 108:417-426
26. McKinley PA, Smith JL (1990) Age-dependent differences in reorganization of primary somatosensory cortex following low thoracic (T12) spinal cord transection in cats. J Neurosci 10: 1429-1443
27. McKinley PA, Jenkins WM, Smith JL, Merzenich MM (1987) Age-dependent capacity for somatosensory cortex reorganization in chronic spinal cats. Brain Res 428:136-139
28. Oladehin A, Pearson PP, Li CX, Johnson EF, Waters RS (1997) Cortical-cortical connections between the shoulder and forepaw representations within the forepaw barrel subfield of the somatosensory cortex: a PHA-L study in adult rat. Soc Neurosci Abstr 23:2346
29. Pearson PP, Li CX, Johnson EF, Waters RS (1996) Effects of large-scale limb deafferentations on the morphological and physiological organization of rat forepaw barrel subfield (FBS) are dependent on the time of deafferentation. Soc Neurosci Abstr 22:1055
30. Pons TP, Garraghty PE, Ommaya AK, Kaas JH, Taub E, Mishkin M (1991) Massive cortical reorganization after sensory deafferentation in adult macaques. Science 252:1857-1860
31. Wall JT, Cusick CG (1984) Cutaneous responsiveness in primary somatosensory (S-I) hindpaw cortex before and after partial hindpaw deafferentation in adult rats. J Neurosci 4:1499-1515
32. Wall JT, Cusick CG (1986) The representation of peripheral nerve inputs in the S-I hindpaw cortex of rats raised with incompletely innervated hindpaws. J Neurosci 6:1129-1147
33. Wall PD, Egger MD (1971) Formation of new connections in adult rat brains after partial deafferentation. Nature 232:542-545
34. Wall JT, Cusick CG, Migani-Wall SA, Wiley RG (1988) Cortical organization after treatment of a peripheral nerve with ricin: an evaluation of the relationship between sensory neuron death and cortical adjustments after nerve injury. J Comp Neurol 277:578-592
35. Waters RS, McCandlish CA, Cooper NGF (1990) Early development of SI cortical barrel subfield representation of forelimb in normal and deafferented neonatal rat as delineated by peroxidase conjugated lectin, peanut agglutinin (PNA). Exp Brain Res 81:234-240
36. Waters RS, Li CX, McCandlish CA (1995a) Relationship between the organization of the forepaw barrel subfield (FBS) and the representation of the forepaw in layer IV of rat somatosensory (SI) cortex. Exp Brain Res 103:183-197
37. Waters RS, McCandlish CA, Li CX (1995b) Organization and development of the forepaw representation in barrel subfield in somatosensory cortex of rat. In: Jones EG, Diamond IT (eds) Rodent barrel cortex. Plenum Press, New York, 11:77-122
38. Welker C (1976) Microelectrode delineation of fine grain somatotopic organization of SmI cerebral neocortex in albino rat. Brain Res 166:173-190
39. Wong-Riley MTT, Welt C (1980) Histochemical changes in cytochrome oxidase of cortical barrels after vibrissal removal in neonatal and adult mice. Proc Natl Acad Sci USA 77: 2333-2337
40. Zarzecki P, Witte S, Smits E, Gordon DC, Kirchberger P, Rasmusson DD (1993) Synaptic mechanisms of cortical representational plasticity: somatosensory and corticocortical EPSPs in reorganized raccoon SI cortex. J Neurophysiol 69: 1422-1432