Early suppression of lymphoproliferative response in dogs with natural infection by Leishmania infantum

Veterinary Immunology and Immunopathology

Volumn 70, Issue 1-2, 1999, Pages 95-103

  De Luna, R ^a   Vuotto, M L ^b   Ielpo, M T L ^b   Ambrosio, R ^a   Piantedosi, D ^a   Moscatiello, V ^b   Ciaramella, P ^a   Scalone, A ^c   Gradoni, L ^c   Mancino, D ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c Laboratorio di Parassitologia   (Italy)

Author keywords

Dog; Leishmania infantum; Leishmaniasis; Lymphocyte proliferation

Indexed keywords

ANTIGEN; CONCANAVALIN A; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; POKEWEED MITOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; IMMUNE RESPONSE; LEISHMANIA INFANTUM; LEISHMANIASIS; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN;

ANIMALS; ANTIGENS, PROTOZOAN; CONCANAVALIN A; DOG DISEASES; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LYMPHOCYTE ACTIVATION; MALE; PHYTOHEMAGGLUTININS; POKEWEED MITOGENS;

ANIMALIA; CANIS FAMILIARIS; LEISHMANIA INFANTUM; PHYTOLACCACEAE;

EID: 0032821409     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(99)00073-2     Document Type: Article

References (21)

1. Barral A., Carvalho E.M., Badaro R., Barral-Neto M. Suppression of lymphocyte proliferative responses by sera from patients with American visceral leishmaniasis. Am. J. Trop. Med. Hyg. 35:1986;735-742.
2. Boyum A. Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21:1968;97.
3. Cabral M., O'Grady J.E., Gomes S., Sousa J.C., Thompson H., Alexander J. The immunology of canine leishmaniosis: strong evidence for a developing disease spectrum from asymptomatic dogs. Vet. Parasitol. 76:1998;173-180.
4. Campos-Neto A., Soong L., Cordova J.L., Sant'Angelo D., Skeiky Y.A., Ruddle N.H., Reed S.G., McMahon-Pratt D. Cloning and expression of a Leishmania donovani gene instructed by a peptide isolated from major histocompatibility complex class II molecules of infected macrophages. J. Exp. Med. 182:1995;1423-1433.
5. Cetron M.S., Basilio F.P., Moraes A.P., Sousa A.Q., Paes J.N., Kahn S.J., Wener M.H., Van Voorhis W.C. Humoral and cellular immune response of adults from northeastern Brazil with chronic Trypanosoma cruzi infection: depressed cellular immune response to T. cruzi antigen among Chagas' disease patients with symptomatic versus indeterminate infection. Am. J. Trop. Med. Hyg. 49:1993;370-382.
6. Evans, D.A., 1987. Leishmania. In: Taylor, A.E.R., Baker, J.R. (Eds.), In vitro Methods for Parasite Cultivation. Academic Press, London, pp. 52-75.
7. Evans T.G., Smith D., Pearson R.D. Humoral factors and nonspecific immune suppression in Syrian hamsters infected with Leishmania donovani. J. Parasitol. 76:1990;212-217.
8. Gradoni L., Maroli M., Gramiccia M., Mancianti F. Leishmania infantum infection rates in Phlebotomus perniciosus fed on naturally infected dogs under antimonial treatment. Med. Vet. Entomol. 1:1987;339-342.
9. Gradoni, L., De Luna, R., Oliva, G., Scalone, A., Mondesire, R., Simpson, D., Frank, G., 1997. Evaluation of a recombinant Leishmania chagasi antigen as a diagnostic marker for Leishmania infantum-infected dogs. Proc. World Congr. Leishmaniosis, Istanbul. In: Acta Parasitol. Turcica, 21 (Suppl. 1), 99.
10. Keenan C.M., Hendricks L.D., Lightner L., Webster H.K., Johnson A.J. Visceral Leishmaniasis in the German shephard dog I. Infection, clinical disease, clinical disease and clinical pathology. Vet. Pathol. 21:1984;74-79.
11. Kristensen B., Kristensen F., Vandevelde M., Higgins R.J., De Weck A.L. Canine lymphocyte cultures in vitro: evaluation of peripheral blood lymphocyte response to mitogens. Vet. Immunol. Immunopathol. 3:1982;439-448.
12. Lanotte G., Rioux J.A., Perières J., Vollhardt Y. Ecologie des leishmaniases dans le sud de la France 10. Les formes evolutives de la leishmaniose viscèrale canine. Ann. Parasitol. Hum. Comp. 54:1979;277-295.
13. London C.A., Abbas A.K., Kelso A. Helper T cell subsets: heterogeneity, functions and development. Vet. Immunol. Immunopathol. 63:1998;37-44.
14. Maroli M., Gramiccia M., Gradoni L., Troiani M., Ascione R. Natural infection of Phlebotomus perniciosus with MON 72 zymodeme of Leishmania infantum in the Campania region of Italy. Acta Trop. 57:1993;333-335.
15. Martinez-Moreno A., Moreno T., Martinez-Moreno F.J., Acosta I., Hernendez S. Humoral and cell-mediated immunity in natural and experimental canine leishmaniasis. Vet. Immunol. Immunopathol. 48:1995;209-220.
16. Nickol A.D., Bonventre P.F. Visceral leishmaniasis in congenic mice of susceptible and resistant phenotypes: T-lymphocytes mediated immunosuppression. Infect. Immun. 50:1985;169-174.
17. Oppenheim, J.J., Rosenstreich, D.L., 1976. Lymphocyte transformation: utilization of automatic harvesters. In: Bloom, B.R., David, J.R. (Eds.), In vitro Methods in Cell-mediated and Tumor Immunity. Academic Press, London, pp. 573-585.
18. Pinelli E., Killick-Kendrick R., Wagenaar J., Bernadina W., Del Real G., Ruitenberg J. Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum. Infect. Immun. 62:1994;229-235.
19. Pozio E., Gradoni L., Bettini S., Gramiccia M. Canine leishmaniasis in the focus of Monte Argentario (Grosseto). Acta Trop. 38:1981;383-393.
20. Skeiky Y.A., Guderian L.A., Benson D.R., Bacelar O., Carvalho E.M., Kubin M., Badaro R., Trinchieri G., Reed S.G. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J. Exp. Med. 181:1995;1527-1537.
21. World Health Organization, 1991. Control of the leishmaniases. W.H.O. Tech. Rep. Ser. No. 793, Geneva.