Deflazacort - An alternative to prednisolone?

Drug and Therapeutics Bulletin

Volumn 37, Issue 8, 1999, Pages 57-58

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

DEFLAZACORT; GLUCOSE; PREDNISOLONE; PREDNISONE;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; BONE MINERAL; CLINICAL TRIAL; CORTICOSTEROID THERAPY; DIABETES MELLITUS; DRUG COST; DRUG EFFICACY; DRUG ELIMINATION; GLUCOSE INTOLERANCE; GROWTH RETARDATION; HUMAN; HYPERTENSION; INFECTION; META ANALYSIS; NEPHROTIC SYNDROME; NEUROLOGIC DISEASE; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; RHEUMATIC DISEASE; SHORT SURVEY;

EID: 0032820148     PISSN: 00126543     EISSN: None     Source Type: Journal    
DOI: 10.1136/dtb.1999.37857     Document Type: Short Survey

References (18)

1. Committee on Safety of Medicines, Medicines Control Agency. Calcort (deflazacort): advertising has been withdrawn. Curr Probl Pharmacovigilance 1998; 24: 10.
2. Deflazacort. Summary of product characteristics, UK. Shire Pharmaceuticals Limited, April 1998.
3. Imbimbo B, Tuzi T, Porzio F, Schiavetti L. Clinical equivalence of a new glucocorticoid, deflazacort and prednisone in rheumatoid arthritis and S.L.E. patients. Adv Exp Med Biol 1984; 171: 241-56.
4. Messina OD, Barreira JC, Zanchetta JR et al. Effect of low doses of deflazacort vs prednisone on bone mineral content in premenopausal rheumatoid arthritis. J Rheumatol 1992; 19: 1520-6.
5. Eberhardt R, Krüger K, Reiter W, Gross W, Zwingers T. Long-term therapy with the new glucocorticosteroid deflazacort in rheumatoid arthritis. Double-blind controlled randomized 12-months study against prednisone. Arzneimittelforschung 1994; 44: 642-7.
6. Krogsgaard MR, Thamsborg G, Lund B. Changes in bone mass during low dose corticosteroid treatment in patients with polymyalgia rheumatica: a double blind, prospective comparison between prednisolone and deflazacort. Ann Rheum Dis 1996; 55: 143-6.
7. Loftus J, Allen R, Hesp R et al. Randomized, double-blind trial of deflazacort versus prednisone in juvenile chronic (or rheumatoid) arthritis: a relatively bone-sparing effect of deflazacort. Pediatrics 1991; 88: 428-36.
8. Fontana A, Manfredi S, Vergallo G et al. Long term treatment of steroid-dependent asthma with deflazacort and prednisone. Allergy 1993; 48 (suppl): 86 [abstract 1472].
9. Rizzato G, Riboldi A, Imbimbo B, Torresin A, Milani S. The long-term efficacy and safety of two different corticosteroids in chronic sarcoidosis. Resp Med 1997; 91: 449-60.
10. Olgaard K, Storm T, von Wowern N et al. Glucocorticoid-induced osteoporosis in the lumbar spine, forearm, and mandible of nephrotic patients: a double-blind study on the high-dose, long-term effects of prednisone versus deflazacort. Calcif Tissue Int 1992; 50: 490-7.
11. Broyer M, Terzi F, Lehnert A, Gagnadoux M-F, Guest G, Niaudet P. A controlled study of deflazacort in the treatment of idiopathic nephrotic syndrome. Pediatr Nephrol 1997; 11: 418-22.
12. Pagano G, Lombardi A, Ferraris GM, Imbimbo B, Cavallo Perin P. Acute effect of prednisone and deflazacort on glucose tolerance in prediabetic subjects. Eur J Clin Pharmacol 1982; 22: 469-71.
13. Bruno A, Pagano G, Benzi L et al. Change in glucose metabolism after long-term treatment with deflazacort and betamethasone. Eur J Clin Pharmacol 1992; 43: 47-50.
14. Kim YS, Kim SM, Kim SI et al. Post-transplantation diabetes is better controlled after conversion from prednisone to deflazacort: a prospective trial in renal transplants. Transpl Int 1997; 10: 197-201.
15. Gray R, Harrington C, Couton L, Calloway J, de Broe M, Kanis J. Long-term treatment of chronic inflammatory disorders with deflazacort. J Orthop Rheum 1990; 3: 15-27.
16. Montecucco C, Baldi F, Fortina A et al. Serum osteocalcin (bone Gla-protein) following corticosteroid therapy in postmenopausal women with rheumatoid arthritis. Comparison of the effect of prednisone and deflazacort. Clin Rheumatol 1988; 7: 366-71.
17. Babadjanova G, Allolio B, Vollmer M, Reincke M, Schulte HM. Comparison of the pharmacodynamic effects of deflazacort and prednisolone in healthy subjects. Eur J Clin Pharmacol 1996; 51: 53-7.
18. LoCascio V, Ballanti P, Milani S et al. A histomorphometric longterm longitudinal study of trabecular bone loss in glucocorticoid-treated patients: prednisone versus deflazacort. Calcif Tissue Int 1998; 62: 199-204.