Role of peroxisomes in isoprenoid biosynthesis

Journal of Histochemistry and Cytochemistry

Volumn 47, Issue 9, 1999, Pages 1127-1132

  Aboushadi, Nahla ^a   Engfelt, William Harrison ^a   Paton, Vincent G ^a   Krisans, Skaidrite K ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Cholesterol; HMG CoA reductase; Isoprenoids; Peroxisomes

Indexed keywords

CARBOXYLYASE; GERANYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPENTENYL DIPHOSPHATE DELTA ISOMERASE; ISOPRENOID; MEVALONIC ACID; PHOSPHOTRANSFERASE;

CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CHOLESTEROL SYNTHESIS; CONFERENCE PAPER; ENDOPLASMIC RETICULUM; ENZYME REGULATION; GENE MUTATION; PEROXISOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEROL SYNTHESIS;

MAMMALIA;

EID: 0032820063     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215549904700904     Document Type: Conference Paper

References (30)

1. Aboushadi N, Krisans SK (1998) Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. J Lipid Res 39:1781-1791
2. Appelkvist EL, Reinhart M, Fischer R, Billheimer J, Dallner G (1990) Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes. Arch Biochem Biophys 282:318-325
3. Basson ME, Thorsness M, Rine J (1986) Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci USA 83:5563-5567
4. Biardi L, Krisans SK (1996) Compartmentalization of cholesterol biosynthesis: conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes. J Biol Chem 271:1784-1788
5. Biardi L, Sreedhar A, Zokei A, Vartak NB, Shackelford JE, Keller GA, Krisans SK. (1994) Mevalonate kinase is predominantly localized in peroxisomes and is defective in patients with peroxisome deficient disorders. J Biol Chem 269:1197-1205
6. Chambliss KL, Slaughter CA, Schreiner R, Hoffman GF, Gibson M (1996) Molecular cloning and expression of human phosphomevalonate kinase and identification of consensus peroxisomal targeting sequence (PTS). J Biol Chem 271:17330-17334
7. Elgersma Y, Vos A, van den Berg M, van Roermund CWT, van der Sluijs P, Distel B, Tabak HF (1996) Analysis of the carboxyl-terminal peroxisomal targeting signal 1 in a homologous context in Saccharomyces cervisiae. J Biol Chem 271:26375-26382
8. Engfelt HW, Masuda K, Paton VG, Krisans SK (1998) Splice donor site mutations in the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene causes a deficiency of the endoplasmic reticulum 3-hydroxy-3-methylglutaryl coenzyme A reductase protein in UT2 cells. J Lipid Res 39:2182-2191
9. Engfelt WH, Shackelford JE, Aboushadi N, Jessani N, Masuda K, Paton VG, Keller GA, Krisans SK (1997) The characterization of the UT-2 cells. The induction of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A. J Biol Chem 272:24579-24587
10. Enjuto M, Balcells L, Campos N, Caelles C, Arro M, Boronat A (1994) Arabidopsis thaliana contains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme. Proc Natl Acad Sci USA. 91: 927-931
11. Hampton R, Dimster-Denk D, Jasper R (1996) The biology of HMG-CoA reductase: the pros of contra-regulation. Trends Biol Sci 21:140-145
12. Hodge VJ, Gould SJ, Subramani S, Moser HW, Krisans SK (1991) Normal cholesterol synthesis in human cells requires functional peroxisomes. Biochem Biophys Res Commun 181:537-541
13. Hovik R, Brodai B, Bartlett K, Osmundsen H (1991) Metabolism of acetyl-CoA by isolated peroxisomal fractions: formation of acetate and acetyl-CoA. J Lipid Res 32:993-999
14. Keller GA, Barton MC, Shapiro DJ, Singer SJ (1985) 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells. Proc Natl Acad Sci USA 82:770-774
15. Keller GA, Pazirandeh M, Krisans SK (1986) 3-Hydroxy-3-methylglutaryl coenzyme A reductase localized in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analysis. J Cell Biol 103:875-886
16. Krisans SK (1996) Cell compartmentalization of cholesterol biosynthesis. In Reddy JK, Suga T, Mannaerts GP, Lazarow PB, Subramani S, eds. Peroxisomes Biology and Role in Toxicology and Disease. Ann NY Acad Sci 804:142-164
17. Krisans SK, Ericsson J, Edwards PA, Keller GA (1994) Farnesyldiphosphate synthase is localized in peroxisomes. J Biol Chem 269:14165-14169
18. Krisans SK, Rusnak N, Keller GA, Edwards PA (1988) Localization of 3-hydroxy-3-methylglutaryl coenzyme A synthase in rat liver peroxisomes. J Cell Biol 107:122
19. Lazarow PB, Moser HW (1995) Disorders of peroxisome biogenesis. In Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolism and Molecular Basis of Inherited Diseases. New York, Mcgraw-Hill, 2287-2324
20. Mandel HM, Getsis M, Rosenblat M, Bernat M, Avriam M (1995) Reduced cellular cholesterol content in peroxisome-deficient fibroblasts is associated with impaired uptake of the patient's low density lipoprotein and with reduced cholesterol synthesis. J Lipid Res 36:1385-1391
21. Mosley ST, Brown MS, Anderson GW, Goldstein JL (1983) Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Biol Chem 258:13875-13881
22. Paton VG, Shackelford JE, Krisans SK (1997) Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes. J Biol Chem 272:18945-18950
23. Rusnak N, Krisans SK (1987) Diurnal variation of HMG-CoA reductase activity in rat liver peroxisomes. Biochem Biophys Res Commun 148:890-895
24. Stamellos KD, Shackelford JE, Tanaka RD, Krisans SK (1992) Mevalonate kinase is localized in rat liver peroxisomes. J Biol Chem 267:5560-5568
25. Stermer BA, Bianchini GM, Korth KL (1994) Regulation of HMG-CoA reductase activity in plants. J Lipid Res 35:1133-1140
26. Subramani S (1993) Protein import into peroxisomes and biogenesis of the organelle. Annu Rev Cell Biol 9:445-478
27. Tanaka RD, Lee YL, Schafer BL, Kratunis VJ, Mohler WA, Robinson GW, Mosley ST (1990) Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver. Proc Natl Acad Sci USA 87:2872-2876
28. Thompson SL, Krisans SK (1990) Rat liver peroxisomes catalyze the initial steps in cholesterol synthesis. J Biol Chem 265:5731-5735
29. Toth JM, Huwyler L (1996) Molecular cloning and expression of cDNAs encoding human and yeast pyrophosphate decarboxylase. J Biol Chem 271:7895-7898
30. Xuan JM, Kowalski J, Chambers AF, Denhardt DT (1994) A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase. Genomics 20:129-131