Effects of pentoxifylline and protein kinase C inhibitor on phorbol ester-induced intercellular adhesion molecule-1 expression in brain microvascular endothelial cells

Acta Pharmacologica Sinica

Volumn 20, Issue 8, 1999, Pages 741-744

  Chu, Zhi Yong ^a   Rui, Yao Cheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cultured cells; Intercellular adhesion molecule l; Pentoxifylline; Protein kinase C; Tetradecanoyl phorbol acetate; Vascular endothelium

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; PENTOXIFYLLINE; PHORBOL ESTER; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ARTICLE; BRAIN BLOOD VESSEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MALE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; VASCULAR ENDOTHELIUM;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BRAIN; CAPILLARIES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FEMALE; INTERCELLULAR ADHESION MOLECULE-1; MALE; PENTOXIFYLLINE; PROTEIN KINASE C; RATS; RATS, WISTAR; TETRADECANOYLPHORBOL ACETATE; VASODILATOR AGENTS;

EID: 0032819514     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Fabry Z, Raine CS, Hart MN. Nervous tissue as an immune compartment: the dialect of the immune response in the CMS. Immunol Today 1994; 15: 218-24.
2. Traugott U, Shevach E, Chiba J, Stone JH, Raine CS. Autoimmune encephalomyelitis: simultaneous identification of T and B cells in the target organ. Science 1981; 214: 1251-3.
3. Takahashi M, Ikada U, Masuyama JI, Kitagaua SI, Kasahara T, Masaki S, et al. Involvement of adhesion molecules in human monocyte adhesion to and transmigration through endothelial cells in vitro. Atherosclerosis 1994; 108: 73-81.
4. Windmeier C, Gressner AM. Pharmacological aspects of pentoxifyllinee with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen Pharmacol 1997; 29: 2181-96.
5. Stins MF, Gilles F, Kim KS. Selective expression of adhesion molecules on human brain microvascular endothelial cells. J Neuroimmunol 1997; 76: 81-90.
6. Maciag T, Cerundolo J, Ilsley S, Kelley PR, Forand R. An endothelial cell growth factor from bovine hypothalamus: Identification and partial characterization. Proc Natl Acad Sci USA 1979; 76: 5674-8.
7. Ikeda U, Ikeda M, Scino Y, Takahashi M, Kasahara T, Kano S, et al. Expression of intercellular adhesion molecule-1 on rat vascular smooth muscle cells by proinflammatory cytokines. Atherosclerosis 1993; 101: 6168.
8. Beekhuizen H, Van Faith R. Monocyte adherence to human vascular endothelium. J Leukocyte Biol 1993; 54: 363-78.
9. Vaporciyan AA, Delisser HM, Yan HC, Mendiguren II, Thom SR, Jones HL, et al. Involvement of plateletendothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science 1993; 262: 1580-2.
10. Okuda Y, Sakoda S, Fujimura H, Yanagihara T. Pentoxifylline delays the onset of experimental allergic encephalomyelitis in mice by modulating cytokine production in peripheral blood mononuclear cells. Immunopharmacology 1996; 35: 141-8.