dl-3-n-Butylphthalide attenuates reperfusion-induced blood-brain barrier damage after focal cerebral ischemia in rats

Acta Pharmacologica Sinica

Volumn 20, Issue 8, 1999, Pages 696-700

  Chong, Zhao Zhong ^a   Feng, Yi Pu ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Blood brain barrier; Brain edema; Butylphthalide; Capiliary permeability; Electron microscopy; Evans blue; Immunohistochemistry; Reperfusion injury; Transient cerebral ischemia; Vascular endothelium

Indexed keywords

BUTYLPHTHALIDE; PHTHALIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN PROTECTION; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DRUG MECHANISM; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; RAT; REPERFUSION INJURY; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; BENZOFURANS; BLOOD-BRAIN BARRIER; CAPILLARIES; CAPILLARY PERMEABILITY; CEREBRAL CORTEX; IMMUNOGLOBULIN G; ISCHEMIC ATTACK, TRANSIENT; MALE; MICROSCOPY, ELECTRON; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 0032819276     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Cole DJ, Matsumura JS, Drummond JC, Schultz RL, Wong MH. Time- and pressure-dependent changes in blood-brain barrier permeability after temporary middle cerebral artery occlusion in rats. Acta Neuropathol (Berl) 1991; 82: 266-73.
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7. Deng WB, Feng YP. Effect of dl-3-n-butylphthalide on brain edema in rats subjected to focal cerebral ischemia. Chin Med Sci J 1997; 12: 102-6.