The effect of cimetidine on the steady-state pharmacokinetics and pharmacodynamics of warfarin in humans

European Journal of Clinical Pharmacology

Volumn 55, Issue 5, 1999, Pages 399-404

  Niopas, I ^a   Toon, S ^b   Aarons, L ^c   Rowland, M ^c  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Medeval Ltd   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cimetidine; Drug drug interaction; Warfarin

Indexed keywords

BLOOD CLOTTING FACTOR 7; CIMETIDINE; PROTHROMBIN; WARFARIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; HUMAN; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; PROTHROMBIN TIME; RACEMIC MIXTURE; STEADY STATE;

ADOLESCENT; ADULT; ANTICOAGULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIMETIDINE; DRUG INTERACTIONS; FACTOR VII; HISTAMINE H2 ANTAGONISTS; HUMANS; MALE; PROTHROMBIN TIME; WARFARIN;

EID: 0032818745     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050647     Document Type: Article

References (37)

1. Freston JW (1982) Cimetidine. I. Developments, pharmacology, and efficacy. Ann Intern Med 97: 573-580
2. Collen MJ, Howard JM, McArthur KF, Raufman JP, Cornelius MJ, Ciarleglio CA, Gardner JD, Jensen RT (1984) Comparison of ranitidine and cimetidine in the treatment of gastric hypersecretion. Ann Intern Med 100: 52-58
3. Somogyi A, Gugler R (1982) Drug interactions with cimetidine. Clin Pharmacokinet 7: 23-41
4. Sedman AJ (1984) Cimetidine-drug interactions. Am J Med 76: 109-114
5. Gerber MC, Tejwani GA, Gerber N, Bianchine JR (1985) Drug interactions with cimetidine: An update. Pharmacol Ther 27: 353-370
6. Somogyi A, Muirhead M (1987) Pharmacokinetic interactions of cimetidine 1987. Clin Pharmacokinet 12: 321-366
7. Bell JA, Gower AJ, Martin LE, Mills EN, Smith WP (1981) Interaction of H2-receptor antagonists with drug-metabolising enzymes. Biochem Soc Trans 9: 13-14
8. Knodell RG, Browne DG, Gwozdz GP, Brian WR, Guengerich FP (1991) Differential inhibition of individual human liver cytochromes P-450 by cimetidine. Gastroenterology 101: 1680-1691
9. Levy RH (1995) Cytochrome P450 isozymes and antiepileptic drug interactions. Epilepsia 36[Suppl 5]: S8-S13
10. Breckenridge A, Orme M, Wesseling H, Lewis RJ, Gibbons R (1974) Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man. Clin Pharmacol Ther 15: 424-430
11. Choonara IA, Haynes BP, Cholerton S, Breckenridge AM, Park BK (1986) Enantiomers of warfarin and vitamin K1 metabolism. Br J Clin Pharmacol 22: 729-732
12. Rettie AE, Korzekwa KR, Kunze KL, Lawrence RF, Eddy AC, Aoyama T, Gelboin HV, Gonzalez FJ, Trager WF (1992) Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem Res Toxicol 5: 54-59
13. Kaminsky LS, de Morais SM, Faletto MB, Dunbar DA, Golstein JA (1993) Correlation of human cytochrome P4502 C substrate specificities with primary structure: Warfarin as a probe. Mol Pharmacol 43: 234-249
14. Serlin MJ, Sibeon RG, Mossman S, Breckenridge AM, Williams JR, Atwood JL, Willoughby JM (1979) Cimetidine, interaction with oral anticoagulants in man. Lancet 2: 317-319
15. Kerley B, Ali M (1982) Cimetidine potentiation of warfarin action. Can Med Assoc J 126: 116
16. O'Reilly RA (1984) Comparative interaction of cimetidine and ranitidine with racemic warfarin in man. Arch Intern Med 144: 989-991
17. Toon S, Hopkins KJ, Garstang FM, Rowland M (1987) Comparative effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of warfarin in man. Eur J Clin Pharmacol 32: 165-172
18. Niopas I, Toon S, Rowland M (1991) Further insight into the stereoselective interaction between warfarin and cimetidine in man. Br J Clin Pharmacol 32: 508-511
19. Choonara IA, Cholerton S, Haynes BP, Breckenridge AM, Park BK (1986) Stereoselective interaction between the R enantiomer of warfarin and cimetidine. Br J Clin Pharmacol 21: 271-277
20. Pitsiu M, Parker EM, Aarons L, Rowland M (1993) Population pharmacokinetics and pharmacodynamics of warfarin in healthy young adults. Eur J Pharm Sci 1: 151-157
21. Banfield C, Rowland M (1984) Stereospecific fluorescence high-performance liquid chromatographic analysis of warfarin and its metabolites in plasma and urine. J Pharm Sci 73: 1392-1396
22. Quick AJ (1966) Haemorrhagic Diseases and Thrombosis, 2nd Edn. Lea and Febiger, Philadelphia, pp 391-395
23. Pitsiu M, Parker EM, Aarons L, Holt B, Rowland M (1992) A comparison of the relative sensitivities of factor VII and prothrombin time measurements in detecting drug interactions with warfarin. Eur J Clin Pharmacol 42: 645-650
24. Gibaldi M, Perrier D (1982) Pharmacokinetics, 2nd Edn. Marcel Dekker, New York, pp 409-416
25. Abernethy DR, Kaminsky LS, Dickinson TH (1991) Selective inhibition of warfarin metabolism by diltiazem in humans. J Pharmacol Exp Ther 257: 411-415
26. Toon S, Low LK, Gibaldi M, Trager WF, O'Reilly RA, Motley CH, Goulart DA (1986) The warfarin-sulfinpyrazone interaction: Stereochemical considerations. Clin Pharmacol Ther 39: 15-24
27. Banfield CR, O'Reilly RA, Chan E, Rowland M (1983) Phenylbutazone-warfarin interaction in man. Further stereochemical and metabolic considerations. Br J Clin Pharmacol 16: 669-675
28. Heimark LD, Wienkers L, Kunze K, Gibaldi M, Eddy AC, Trager WF, O'Reilly RA, Goulart DA (1992) The mechanism of the interaction between amiodarone and warfarin in humans. Clin Pharmacol Ther 51: 398-407
29. O'Reilly RA, Goulart DA, Kunze KL, Neal J, Gibaldi M, Eddy AC, O'Reilly RA (1992) Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects. Clin Pharmacol Ther 51: 656-67
30. Chan KK, Lewis RJ, Trager WF (1972) Absolute configuration of the four warfarin alcohols. J Med Chem 15: 1265-1270
31. Moreland TA, Hewick DS (1975) Studies on a ketone reductase in human and rat liver and kidney soluble fraction using warfarin as a substrate. Biochem Pharmacol 25: 1953-1957
32. Lewis R, Trager W (1970) Warfarin metabolism in man: Identification of metabolites in urine. J Clin Invest 49: 907-913
33. Park BK (1988) Warfarin: Metabolism and mode of action. Biochem Pharmacol 37: 19-27
34. Hermans JJR, Thijssen HHW (1993) Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol. P450 isozyme diversity determines the differences in their pharmacokinetics. Br J Clin Pharmacol 110: 482-490
35. Unge P, Svedberg LE, Nordgren A, Blom H, Andersson T, Lagerstrom PO, Idstrom JP (1992) A study of the interaction of omeprazole and warfarin in anticoagulated patients. Br J Clin Pharmacol 34: 509-512
36. Gidal BE, Sorkness CA, McGill KA, Larson R, Levine RR (1995) Evaluation of a potential enantioselective interaction between ticlopidine and warfarin in chronically anticoagulant patients. Ther Drug Monit 17: 33-38
37. Awni WM, Hussein Z, Granneman GR, Patterson KJ, Dube LM, Cavanaugh JH (1995) Pharmacodynamic and stereoselective pharmacokinetic interactions between zileuton and warfarin in humans. Clin Pharmacokinet 29[Suppl 2]: 67-76