Deficit in selective and divided attention associated with cholinergic basal forebrain immunotoxic lesion produced by 192-saporin; motoric/sensory deficit associated with Purkinje cell immunotoxic lesion produced by OX7- saporin

Neurobiology of Learning and Memory

Volumn 71, Issue 3, 1999, Pages 325-352

  Waite, Jerene J ^a   Wardlow, Marilyn L ^a   Power, Ann E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acetylcholine; Attention; Behavior; Cholinergic basal forebrain; Immunotoxin; Lesion; Purkinje cells; Rats

Indexed keywords

ACETYLCHOLINE; IMMUNOTOXIN; SAPORIN;

ACOUSTIC REFLEX; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; CEREBELLUM INJURY; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; FOREBRAIN; IMMUNOTOXICITY; MALE; MAZE TEST; MOTOR DYSFUNCTION; NERVE CELL LESION; NONHUMAN; OPEN FIELD BEHAVIOR; PASSIVE AVOIDANCE; PURKINJE CELL; RAT; RESPONSE TIME; SELECTIVE ATTENTION; SENSORY DYSFUNCTION; STARTLE REFLEX; TASK PERFORMANCE;

EID: 0032818623     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1006/nlme.1998.3884     Document Type: Article

References (63)

1. Allen G., Buxton R. B., Wong E. C., Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science. 275:1997;1940-1943.
2. Bartus R. T., Dean R. L., Pontecorvo M. J., Flicker C. The cholinergic hypothesis: A historical overview, current perspective, and future directions. Annals of the New York Academy of Science. 444:1985;332-358.
3. Baxter M. G., Bucci D. J., Gorman L. K., Wiley R. G., Gallagher M. Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats. Behavioral Neuroscience. 109:1995;714-722.
4. Baxter M. G., Gallagher M. Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input. Behavioral Neuroscience. 110:1996;460-467.
5. Berger-Sweeney J., Heckers S., Mesulam M. M., Wiley R. G., Lappi D. A., Sharma M. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. Journal of Neuroscience. 14:1994;4507-4519.
6. Blokland A. Acetylcholine: A neurotransmitter for learning and memory. Brain Research Reviews. 21:1996;285-300.
7. Book A. A., Wiley R. G., Schweitzer J. B. Specificity of 192 IgG-saporin for NGF receptor-positive cholinergic basal forebrain neurons in the rat. Brain Research. 590:1992;350-355.
8. Book A. A., Wiley R. G., Schweitzer J. B. 192 IgG-saporin 2. Neuropathology in the rat brain. Acta Neuropathologica. 89:1995;519-526.
9. Carli M., Robbins T. W., Evenden J. L., Everitt B. J. Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats: Implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behavioral Brain Research. 9:1983;361-380.
10. Courchesne E., Townsend J., Akshoomoff N. A., Saitoh O., Yeung-Courchesne R., Lincoln A. J., James H. E., Haas R. H., Schreibman L., Lau L. Impairment in shifting attention in autistic and cerebellar patients. Behavioral Neuroscience. 108:1994;848-865.
11. Dahhaoui M., Lannou J., Stelz T., Caston J., Guastavino J. M. Role of the cerebellum in spatial orientation in the rat. Behavioral and Neural Biology. 58:1992;180-189.
12. Davis T. L., Wiley R. G. Anti-Thy-1 immunotoxin, OX7-saporin, destroys cerebellar Purkinje cells after intraventricular injection in rats. Brain Research. 504:1989;216-222.
13. Dekker A. J., Thal L. J. Effect of delayed treatment with nerve growth factor on choline acetyltransferase activity in the cortex of rats with lesions of the nucleus basalis magnocellularis: Dose requirements. Brain Research. 584:1992;55-63.
14. Dornan W. A., McCampbell A. R., Tinkler G. P., Hickman L. J., Bannon A. W., Decker M. W., Gunther K. L. Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG-saporin. Behavioral Brain Research. 82:1996;247-265.
15. Dougherty K. D., Salat D., Walsh T. J. Intraseptal injection of the cholinergic immunotoxin 192-IgG saporin fails to disrupt latent inhibition in a conditioned taste aversion paradigm. Brain Research. 736:1996;260-269.
16. Dunnett S. B., Everitt B. J., Robbins T. W. The basal forebrain-cortical cholinergic system: Interpreting the functional consequences of excitotoxic lesions. TINS. 14:1991;494-501.
17. Fonnum F. Radiochemical microassays for the determination of choline acetyltransferase and acetylcholinesterase activities. Journal of Biochemistry. 115:1969;465-479.
18. Frautschy S. A., Waite J., Albright T., Sheu J., Winkler J., Martineau D., Lappi D., Gonzales A. M., Thal L. J. Behavioral effects of a FGF receptor toxin in the rat hippocampus. Society for Neuroscience Abstracts. 19:1993;1894.
19. Gao J.-H., Parsons L. M., Bower J. M., Xiong J., Li J., Fox P. T. Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science. 272:1996;545-547.
20. Goodlett C. R. Dissociation of spatial navigation and visual guidance performance in Purkinje cell degeneration (pcd) mutant mice. Behavioural Brain Research. 47:1992;129-141.
21. Guillaumin S., Dahhaoui M., Caston J. Cerebellum and memory: An experimental study in the rat using a passive avoidance conditioning test. Physiology and Behavior. 49:1991;507-511.
22. Heckers S., Ohtake T., Wiley F. G., Lappi D. A., Geula C., Mesulam M. M. Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor. Journal of Neuroscience. 14:1994;1271-1289.
23. Holley L. A., Wiley R. G., Lappi D. A., Sarter M. Cortical cholinergic deafferentation following intracortical infusion of 192 IgG-saporin: A quantitative histochemical study. Brain Research. 663:1994;277-286.
24. Ivry R. Cerebellar involvement in the explicit representation of temporal information. Annals of the New York Academy of Sciences. 682:1993;214-230.
25. Jones D. N. C., Higgins G. A. Effect of scopolamine on visual attention in rats. Psychopharmacology. 120:1995;142-149.
26. Joyal C. C., Meyer C., Jacquart G., Mahler P., Caston J., Lalonde R. Effects of midline and lateral cerebellar lesions on motor coordination and spatial orientation. Brain Research. 739:1996;1-11.
27. Lalonde R., Bensoula A. N., Filali M. Rotorod sensorimotor learning in cerebellar mutant mice. Neuroscience Research. 22:1995;423-426.
28. Lalonde R., Botez M. I. Exploration of a hole-board matrix in nervous mutant mice. Brain Research. 343:1985;356-359.
29. Lalonde R., Botez M. I. Navigational deficits in weaver mutant mice. Brain Research. 398:1986;175-177.
30. Lalonde R., Manseau M., Botez M. I. Delayed spontaneous alternation in Purkinje cell degeneration mutant mice. Neuroscience Letters. 80:1987;343-346.
31. Lalonde R., Thifault S. Absence of an association between motor coordination and spatial orientation in lurcher mutant mice. Behavior Genetics. 24:1994;497-501.
32. Le Marec N., Lalonde R. Sensorimotor learning and retention during equilibrium tests in Purkinje cell degeneration mutant mice. Brain Research. 768:1997;310-316.
33. Le Marec N., Lalonde R. Treadmill performance of mice with cerebellar lesions: 1. Purkinje cell degeneration mutant mice. Behavioral Neuroscience. 112:1998;225-232.
34. Le T. H., Pardo J. V., Hu X. 4 T-fMRI study of nonspatial shifting of selective attention: cerebellar and parietal contributions. Journal of Neurophysiology. 79:1998;1535-1548.
35. Leaton R. N., Supple W. F. J. Medial cerebellum and long-term habituation of acoustic startle in rats. Behavioral Neuroscience. 105:1991;804-816.
36. Lee M. G., Chrobak J. J., Sik A., Wiley R. G., Buzsáki G. Hippocampal theta activity following selective lesion of the septal cholinergic system. Neuroscience. 62:1994;1033-1047.
37. Lindefors N., Boatell M. L., Mahy N., Persson H. Widespread neuronal degeneration after ibotenic acid lesioning of cholinergic neurons in the nucleus basalis revealed by in situ hybridization. Neuroscience Letters. 135:1992;262-264.
38. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biology and Chemistry. 193:1951;265-275.
39. McGaughy J., Kaiser T., Sarter M. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: Selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behavioral Neuroscience. 110:1996;247-265.
40. Muir J. L., Bussey T. J., Everitt B. J., Robbins T. W. Dissociable effects of AMPA-induced lesions of the vertical limb diagonal band of Broca on performance of the 5-choice serial reaction time task and on acquisition of a conditional visual discrimination. Behavioural Brain Research. 82:1996a;31-44.
41. Muir J. L., Dunnett S. B., Robbins T. W., Everitt B. J. Attentional functions of the forebrain cholinergic systems: Effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Experimental Brain Research. 89:1992;611-622.
42. 3. Psychopharmacology. 118:1995;82-92.
43. Muir J. L., Everitt B. J., Robbins T. W. The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. Cerebral Cortex. 6:1996b;470-481.
44. Muir J. L., Page K. J., Sirinathsinghji D. J. S., Robbins T. W., Everitt B. J. Excitotoxic lesions of basal forebrain cholinergic neurons: Effects on learning, memory and attention. Behavioural Brain Research. 57:1993;123-131.
45. Mullen R. J., LaVail M. M. Two new types of retinal degeneration in cerebellar mutant mice. Nature. 258:1975;528-530.
46. Nichelli P., Alway D., Grafman J. Perceptual timing in cerebellar degeneration. Neuropsychologia. 34:1996;863-871.
47. Nilsson O. G., Leanza G., Rosenblad C., Lappi D. A., Wiley R. G., Björklund A. Spatial learning impariments in rats with selective immunolesion of the forebrain cholinergic system. NeuroReport. 3:1992;1005-1008.
48. Pellegrino L. J., Altman J. Effects of differential interference with postnatal cerebellar neurogenesis on motor performance, activity level, and maze learning of rats: A developmental study. Journal of Comparative and Physiological Psychology. 93:1979;1-33.
49. Petrosini L., Molinari M., Dell'Anna M. E. Cerebellar contribution to spatial event processing: Morris water maze and T-maze. European Journal of Neuroscience. 8:1996;1882-1896.
50. Posner M. I., Boies S. J. Components of attention. Psychological Review. 78:1971;391-408.
51. Robbins T. W., Everitt B. J., Marston H. M., Wilkinson J., Jones G. H., Page K. J. Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes. Behavioral Brain Research. 35:1989;221-240.
52. Steckler T., Keith A. B., Wiley R. G., Sahgal A. Cholinergic lesions by 192 IgG-saporin and short-term recognition memory: Role of the septohippocampal projection. Neuroscience. 66:1995;101-114.
53. Steckler T., Muir J. L. Measurement of cognitive function: relating rodent performance with human minds. Cognitive Brain Research. 3:1996;299-308.
54. Torres E. M., Perry T. A., Blokland A., Wilkinson L. S., Wiley R. G., Lappi D. A., Dunnett S. B. Behavioural, histochemical, and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience. 63:1994;95-122.
55. Waite J. J., Chen A. D., Wardlow M. L., Wiley R. G., Lappi D. A., Thal L. J. 192 Immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells. Neuroscience. 65:1995;463-476.
56. Waite J. J., Thal L. J. Lesions of the cholinergic nuclei in the rat basal forebrain: Excitotoxins vs. an immunotoxin. Life Sciences. 58:1996;1947-1953.
57. Waite J. J., Wardlow M. L., Chen A. C., Lappi D. A., Wiley R. G., Thal L. J. Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin. Neuroscience Letters. 169:1994;154-158.
58. Wenk G. L., Stoehr J. D., Quintana G., Mobley S., Wiley R. G. Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats. Journal of Neuroscience. 14:1994;5986-5995.
59. Wiley R. G., Berbos T. G., Deckwerth T. L., Johnson E. M. Jr., Lappi D. A. Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: Modeling the cholinergic degeneration of Alzheimer's disease. Journal of the Neurological Sciences. 128:1995;157-166.
60. Wiley R. G., Oeltmann T. N., Lappi D. A. Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor. Brain Research. 562:1991;149-153.
61. Wiley R. G., Stirpe F., Thorpe P., Oeltmann T. N. Neuronotoxic effects of monoclonal anti-Thy 1 antibody (OX7) coupled to the ribosome inactivating protein, saporin, as studied by suicide transport experiments in the rat. Brain Research. 505:1989;44-54.
62. Wolf L. W., LaRegina M. C., Tolbert D. L. A behavioral study of the development of hereditary cerebellar ataxia in the shaker rat mutant. Behavioural Brain Research. 75:1996;67-81.
63. Zhang Z. J., Berbos T. G., Wrenn C. C., Wiley R. G. Loss of nucleus basalis magnocellularis, but not septal, cholinergic neurons correlates with passive avoidance impairment in rats treated with 192-saporin. Neuroscience Letters. 203:1996;214-218.