In aplastic anemia progenitor cells have a reduced sensitivity to the effects of growth factors

European Journal of Haematology

Volumn 63, Issue 3, 1999, Pages 141-148

  Novitzky, Nicolas ^a,b   Jacobs, Peter ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Aplastic anemia; Bone marrow failure; Cytokines; Hematopoietic progenitor cells; Immunosuppressive therapy

Indexed keywords

CD34 ANTIGEN; RECOMBINANT CYTOKINE; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 3; STEM CELL FACTOR;

APLASTIC ANEMIA; ARTICLE; BONE MARROW CELL; CELL DENSITY; CELL GROWTH; CLONOGENESIS; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0032817002     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.1999.tb01761.x     Document Type: Article

References (35)

1. YOUNG NS. The problem of clonality in aplastic anemia: Dr. Dameshek's riddle, restated. Blood 1992;79:1385-1392.
2. BACIGALUPO A, PODESTA F, FRASSONI F, et al. T-derived colony inhibiting activity (Td/CIA) in aplastic anemia (SAA) and in normal donors. In: YOUNG NS, LEVINE AS, eds. Aplastic Anemia: Stem Cell Biology and Advances in Treatment. New York: Alan R. Liss, 1984;173.
3. FUJIWARA M. Long term culture of marrow cells from patients with aplastic anemia. Nippon Ketsueki Gakkai Zasshi 1990;53:533 540.
4. GORDON MY, DOWDING CR, RILFY GP, et al. Characterization of stroma dependent blast-colony-forming cells in human marrow. J Cell Physiol 1987;130:150-156.
5. DOWDING CR, GORDON MY. Physical, phenotypic and cytochemical characterization of stroma adherent blast-colony-forming cells. Leukemia 1992;6:347 351.
6. NOVITZKY N, JACOBS P. In aplastic anemia following immunosuppressive therapy, the bone marrow stroma supports adequately the growth of haematopoietic stem cells. Exp Hematol 1995;23:1472 1477.
7. NOVITZKY NP, JACOBS P. In aplastic anemia (AA) following ALG therapy the stroma (BMS) is not abnormal while the progenitor cells (PC) are less responsive to growth factors (GF). Blood 1992;80(Suppl.1):1525a.
8. NOVITZKY N, JACOBS P. Marrow stem cell and stroma cell function in aplastic anemia. Br J Haematol 1991;79:531 533.
9. MARSH JCW, CHANG J, TESTA N, et al. The haematopoietic defect in aplastic anemia assessed by long-term marrow culture. Blood 1990;76:1748 1757.
10. MARSH JCW, CHANG J, TESTA NG, et al. In vitro assessment of marrow stem cell and stromal function in aplastic anemia. Br J Haematol 1991;78:258 267.
11. NAWATA J, TOYODA Y, NISIHIRA H, et al. Haematological improvement by long-term administration of recombinant human granuloclyte-colony stimulating factor and recombinant human erythropoietin in a patient with severe aplastic anemia. Eur J Pediatr 1994;153:325.
12. VADHAN-RAJ S, BUESCHER S, LE MAISTRE A, et al. Stimulation of haematopoiesis in patients with bone marrow failure and in patients with malignancy by recombinant granulocyte-macrophage colony-stimulating factor. Blood 1988;72:134-141.
13. KOJIMA S, FUKUDA M, MIYAJIMA Y, et al. Treatment of aplastic anemia in children with recombinant human granulocyte colony-stimulating factor. Blood 1991;77:937-941.
14. NOVITZKY N, PILLAY GS, KOOPMAN B, et al. Haematologic status remains quantitatively and qualitatively abnormal in patients with aplastic anemia following immunosuppressive therapy. Blood 1992;80:(Suppl. 1)1526a.
15. CAMITTA BM, RAPPEPORT JM, PARKMAN R, et al. Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood 1975;45:355-363.
16. WALDMANN H, HALE G, CIVIDALLI G, et al. Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). Lancet 1984;ii:483-486.
17. UGELSTAD J, ELLIGSEN T, BERGE A. Magnetic polymer particles for cell separation. Bone Marrow Transplant 1987;2(Suppl. 2):74a.
18. RASMUSSEN AM, SMALAND EB, ERIKSTEIN B, et al. A new method for detachment of Dynalbeads from positively selected B lymphocytes. J Immunol Methods 1992;146:195-202.
19. BARNSTABLF CJ, BODMER WF, BROWN G, et al. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens new tools for genetic analysis. Cell 1978;14:9 20.
20. MORRISON DF. Multivariant statistical methods. Tokyo: McGraw-Hill, 1976;230 236.
21. LOWRY PA, DEACON D, WHITEFIELD P, et al. Stem cell factor induction of in vitro murine hemopoietic colony formation by "subliminal" cytokine combinations: the role of anchor factors. Blood 1992;80:663 669.
22. BACIGALUPO A, PIAGGIO G, FIGARI O, et al. Response of CFU-GM to increasing doses of rhGM-CSF in patients with aplastic anemia. J Exp Hematol 1991;19:829-832.
23. AOKI I, KATSUMI H, HOMORI M, et al. Responsiveness of bone marrow erythropoietic stem cells (CFU-E and BFU-E) to recombinant human erythropoietin in vitro in aplastic anemia and myelodysplastic syndrome. Am J Hematol 1990;35:6-12.
24. GIBSON FM, SCOPES J, DALY S, et al. In vitro response of normal and aplastic anemia bone marrow to mast cell growth factor and in combination with granulocyte-macrophage colony-stimulating factor and interleukin-3. Exp Hematol 1994;22:302-312.
25. WODNAR-FILIPOWICZ A, TICHELLI A, ZSEBO K, et al. Stem cell factor stimulates in-vitro growth of bone marrow cells from aplastic anemia patients. Blood 1992;79:3196-3202.
26. OLSSON I, GULLBERG U, LANTZ M, et al. The receptors for regulatory molecules of hematopoiesis. Eur J Haematol 1992;48:1-9.
27. CANNISTRA SA, GRIFFIN JD. Regulation of the production and function of granulocytes and monocytes. Semin Hematol 1988;25:173-188.
28. SIEFF CA, EMERSON SG, DONAHUE RE, et al. Human recombinant granulocyte-macrophage colony stimulating factor: a multilineage hematopoietin. Science 1985;230:1171-1173.
29. GASSON JC. Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood 1991;77:1131-1145.
30. POUYSSÉGUR J, SEUWEN K. Transmembrane receptors and intracellular pathways that control cell proliferation. Ann Rev Phys 1992;63:195-210.
31. MERCHAV R, TATARSKY I, SHARON R. Aplastic anemia associated with in vitro Inhibition of erythropoiesis by bone marrow adherent cells. Eur J Haematol 1988;41:429-433.
32. HINTERBERGER W, ADOLF G, AICHINGER G, et al. Further evidence for lymphokine overproduction in severe aplastic anemia. Blood 1988;72:266-272.
33. MACIEJEWSKI JP, ANDERSON S, KATEVAS P, et al. Phenotypic and functional analysis of bone marrow progenitor cell compartment in bone marrow failure. Br J Huematol 1994;87:227-234.
34. MACIEJEWSKI J, SELLERI C, ANDERSON S, et al. Fas antigen expression on CD 34+ human marrow cells is induced by interferon g and potentiates cytokine mediated hematopoietic suppression in vitro. Blood 1985;85:3183-3190.
35. MACIEJEWSKI J, SELLERI C, SATO T, et al. Increased expression of Fas antigen on bone marrow CD34+ cells in patients with aplastic anemia. Br J Haematol 1995;91:245-252.