The epidemiology and pathogenesis of infections caused by the high numbered human herpesviruses in children: HHV-6, HHV-7 and HHV-8

Current Opinion in Infectious Diseases

Volumn 12, Issue 3, 1999, Pages 251-255

  Miyagawa, Hiromi ^a   Yamanishi, Koichi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW TRANSPLANTATION; FEBRILE CONVULSION; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; HUMAN HERPESVIRUS 8; INTRAUTERINE INFECTION; KAPOSI SARCOMA; NEUROLOGIC DISEASE; ORGAN TRANSPLANTATION; REVIEW; SALIVA; SEXUAL TRANSMISSION; VIRUS TRANSMISSION;

EID: 0032816736     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001432-199906000-00016     Document Type: Review

References (35)

1. 1 Salahuddin SZ, Albashi DV, Markham PD, Josephs SF, Strurzenegger S, Kaplan M, et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986; 234:596-601.
2. 2 Hidaka Y, Kusuhara K, Takabayashi A, Okada K, Miyazaki C, Aoki T, et al. Symptomatic primary infection with human herpesvirus 6 variant A. Clin Infect Dis 1997; 24:1022-1023.
3. 3 Randhawa PS, Jenkins FJ, Nalesnik MA, Martens J, Williams PA, Ries A et al. Herpesvirus 6 variant A infection after heart transplantation with giant cell transformation in bile ductular and gastroduodenal epithelium. Am J Surg Pathol 1997; 21:847-853. A patient after heart transplantation had gastroduodenitis, pancreatitis, hepatitis, and encephalitis associated with HHV-6A infection.
4. 4 Hall CB, Caserta MT, Schnabel KC, Long C, Epstein LG, Insel RA, et al. Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A. Clin Infect Dis 1998; 26:132-137. This study found that HHV-6A can be detected more frequently in the CSF than in PBMC.
5. 5 Suga S, Yoshikawa T, Kajita Y, Ozaki T, Asano Y. Prospective study of persistence and excretion of human herpesvirus-6 in patients with exanthem subitum and their parents. Pediatrics 1998; 102:900-904.
6. 6 Lau YL, Peiris M, Chan GC, Chan AC, Chiu D, Ha SY. Primary human herpesvirus 6 infection transmitted from donor to recipient through bone marrow infusion. Bone Marrow Transplant 1998; 2110:1063-1066. In this case the donor had ES at the time of bone marrow harvest, and the recipient acquired primary HHV-6 infection through the bone marrow.
7. 7 Luppi M, Barozzi P, Morris C, Maiorana A, Garber R, Bonacorsi G, et al. Human herpesvirus 6 latently infects early bone marrow progenitors in vivo. J Virol 1999; 73:754-759.
8. 8 Yoshikawa T, Ihira M, Furukawa H, Suga S, Asonuma K, Tanaka K, et al. Four cases of human herpesvirus 6 variant B infection after pediatric liver transplantation. Transplantation 1998; 65:1266-1269. This report is about the manifestations of HHV-6 infection after liver transplantation. In one case HHV-6 infection was suggested to have occurred via a transplanted organ.
9. 9 Adams O, Krempe C, Kogler G, Wernet P, Scheid A. Congenital infections with human herpesvirus 6. J Infect Dis 1998; 178:544-546. The authors report that HHV-6 DNA could be detected in cord blood and there was the possibility of congenital infection with HHV-6.
10. 10 Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, et al. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med 1994; 331:432-438.
11. 11 Jee SH, Long CE, Schnabel KC, Sehgal N, Epstein LG, Hall CB. Risk of recurrent seizures after a primary human herpesvirus 6-induced febrile seizure. Pediatr Infect Dis J 1998; 17:43-48. This prospective study shows that children with febrile seizures associated with HHV-6 infection did not demonstrate an increased risk of recurrent seizures.
12. 12 Huskin J, Farrell K, MacWilliam LM, Colbourne M, Waida E, Tan R, et al. Case-control study of primary human herpesvirus 6 infection in children with febrile seizures. Pediatrics 1998; 101:298.
13. 13 Wade AW, McDonald AT, Acott PD, Lee S, Crocker JF. Human herpes virus-6 or Epstein-Barr virus infection and acute allograft rejection in pediatric kidney transplant recipients: greater risk for immunologically naive recipients. Transplant Proc 1998; 30:2091-2093. This report focused on the role of HHV-6 and Epstein-Barr virus in acute rejection after renal transplantation.
14. 14 Lautenschlager I, Hockerstedt K, Linnavuori K, Taskinen E. Human herpes-virus-6 infection after liver transplantation. Clin Infect Dis 1998; 26:702-707. The authors diagnosed eight individuals with HHV-6 infection in 121 liver transplant patients.
15. 15 Chang FY, Singh N, Gayowski T, Wagener MM, Marino IR. Fever in liver transplant recipients: changing spectrum of etiologic agents. Clin Infect Dis 1998; 26:59-65.
16. 16 Tsujimura H, Iseki T, Date Y, Watanabe J, Kumagai K, Kikuno K, et al. Human herpesvirus-6 encephalitis after bone marrow transplantation: magnetic resonance imaging could identify the involved sites of encephalitis. Eur J Haematol 1998; 61:284-285. This study reports the case of HHV-6 encephalitis after bone marrow transplantation.
17. 17 Appleton AL, Sviland L, Peiris JS, Taylor CE, Wilkes J, Green MA, et al. Human herpes virus-6 infection in marrow graft recipients: role in pathogenesis of graft-versus-host disease. Newcastle upon Tyne Bone Marrow Transplant Group. Bone Marrow Transplant 1995; 16:777-782.
18. 18 Kadakia MP. Human herpesvirus 6 infection and associated pathogenesis following bone marrow transplantation. Leuk Lymphoma 1998; 31:251-266.
19. 19 Cone RW, Huang ML, Corey L, Zeh J, Ashley R, Bowden R. Human herpesvirus 6 infections after bone marrow transplantation: clinical and virologic manifestations. J Infect Dis 1999; 179:311-318.
20. 20 Emery VC, Atkins MC, Bowen EF, Clark DA, Johnson MA, Kidd IM, et al. Interactions between beta-herpesviruses and human immunodeficiency virus in vivo: evidence for increased human immunodeficiency viral load in the presence of human herpesvirus 6. J Med Virol 1999; 57:278-282.
21. 21 Fujisaki H, Tanaka-Taya K, Tanabe H, Hara T, Miyoshi H, Okada S, et al. Detection of human herpesvirus 7 (HHV-7) DNA in breast milk by polymerase chain reaction and prevalence of HHV-7 antibody in breast-fed and bottle-fed Children. J Med Virol 1998; 56:275-279. The authors detected HHV-7 DNA in breast milk and speculated about another transmission route of HHV-7.
22. 22 Lanphear BP, Hall CB, Black J, Auinger P. Risk factors for the early acquisition of human herpesvirus 6 and human herpesvirus 7 infections in children. Pediatr Infect Dis J 1998; 17:792-795.
23. 23 Caserta MT, Hall CB, Schnabel K, Long CE, D'Heron N. Primary human herpesvirus 7 infection: a comparison of human herpesvirus 7 and human herpesvirus 6 infections in children. J Pediatr 1998; 133:386-389.
24. 24 Kempf W, Adams V, Mirandola P, Menotti L, Di Luca D, Wey N, et al. Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen. J Infect Dis 1998; 178:841-845.
25. 25 Lennette ET, Blackbourn DJ, Levy JA. Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 1996; 348:858-861.
26. 26 Blackbourn DJ, Osmond D, Levy JA, Lennette ET. Increased human herpesvirus 8 seroprovalence in young homosexual men who have multiple sex contacts with different partners. J Infect Dis 1999; 179:237-239.
27. 27 Martin JN, Ganem DE, Osmond DH, Pago Shafer KA, Macrae D, Kedes DH. Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 1998; 338:948-954.
28. 28 Zhang X, Fitzpatrick L, Campbell TB, Badaro R, Schechter M, Melo M, et al. Comparison of the prevalence of antibodies to human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in Brazil and Colorado. J Infect Dis 1998; 178:1488-1491.
29. 29 Mayama S, Cuevas LE, Sheldon J, Omar OH, Smith DH, Okong P, et al. Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herposvirus 8) in Ugandan children and adolescents. Int J Cancer 1998; 77:817-820. This paper demonstrated that among Ugandan children KSHV transmission follows a horizontal pattern similar to other herpesviruses.
30. 30 Rabkin CS, Schulz TF, Whitby D, Lennette ET. Magpantay LI, Chatlynne L, Biggar RJ. Interassay correlation of human herpesvirus 8 serologic tests. HHV-8 Interlaboratory Collaborative Group. J Infect Dis 1998; 178:304-309.
31. 31 Diamond C, Brodie SJ, Krieger JN, Huang ML, Koelle DM, Diem K, et al. Human herpesvirus 8 in the prostate glands of men with Kaposi's sarcoma. J Virol 1998; 72:6223-6227. The intermittent replication of HHV-8 in the prostate and subsequent shedding of virus in the semen may be crucial factors for determining whether HHV-8 can be transmitted through sexual activity.
32. 32 Koelle DM, Huang ML, Chandran B, Vieira J, Piepkorn M, Corey L. Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates. J Infect Dis 1997; 176:94-102. This paper suggests that KSHV can replicate in the oropharynx and that salivary contact could contribute to KSHV transmission.
33. 33 Vieira J, Huang ML, Koelle DM, Corey L. Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma. J Virol 1997; 71:7083-7087.
34. 34 LaDuca JR, Love JL, Abbott LZ, Dube S, Freidman-Kien AE, Poiesz BJ. Detection of human herpesvirus 8 DNA sequences in tissues and bodily fluids. J Infect Dis 1998; 173:1610-1615.
35. 35 Blackbourn DJ, Lennette ET, Ambroziak J, Mourich DV, Levy JA. Human herpesvirus 8 detection in nasal secretions and saliva. J Infect Dis 1998; 177:213-216.