Neuroimmunotherapy with subcutaneous low-dose interleukin-2 plus the pineal oncostatic hormones melatonin and 5-methoxytryptamine in untreatable advanced solid neoplasm patients with very poor clinical status

International Journal of Immunotherapy

Volumn 15, Issue 1, 1999, Pages 35-38

  Lissoni, P ^a   Mandala M ^a   Mandelli, A ^a   Fumagalli, L ^a  

^a SAN GERARDO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHOXYTRYPTAMINE; MELATONIN; RECOMBINANT INTERLEUKIN 2;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER IMMUNOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; IMMUNOMODULATION; MALE; NEUROIMMUNOLOGY; ORAL DRUG ADMINISTRATION; PHASE 2 CLINICAL TRIAL; SOLID TUMOR; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032816644     PISSN: 02559625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Regelson W., Pierpaoli W. Melatonin; A rediscovered antitumor hormone? Cancer Invest., 5, 379, 1987.
2. Brzezinsky A. Melatonin in humans. N. Engl. J. Med, 336, 186, 1997.
3. Beck O., Jonsson G., Lundman A. 5-Methoxy-indoles in pineal gland of cow, pig, sheep and rat. Arch. Pharmacol., 318, 49, 1981.
4. Maestroni G.J.M. The immunoneuroendocrine role of melatonin. J. Pineal Res., 14, 1, 1993.
5. Lissoni P., Barni S., Tancini G., et al. A randomized study with subcutaneous low-dose interleukin-2 alone vs. interleukin-2 plus the pineal neurohormone melatonin in advanced solid neoplasm other than renal cancer and melanoma. Br. J. Cancer, 69, 196, 1994.
6. Whittington R., Faulds D. Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer. Drugs, 46, 446, 1993.
7. Sze S.F., Ng T.B., Liu W.K. Antiproliferative effect of pineal indoles on cultured tumor cell lines. J. Pineal Res., 14, 27, 1993.
8. Lissoni P., Barni S., Cattaneo G., et al. Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies. Oncology, 40, 448, 1991.
9. Lissoni R, Rovelli F., Giani L., et al. Endocrine effects of two pineal hormones other than melatonin in healty volunteers: 5-methoxytryptophol and 5-methoxytryptamine. Rec. Progr. Med., 89, 183, 1998.
10. Mclsaac W.M., Farrell G., Taborsky R.G., Taylor A.N. Indole compounds: Isolation from bovine pineal tissue. Science, 148, 102, 1965.